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Iroquois-class homeodomain protein

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Below are the list of possible Iroquois-class homeodomain protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Iroquois-class homeodomain protein IRX-1

 Iroquois-class homeodomain protein IRX-1 ELISA Kit
 Iroquois-class homeodomain protein IRX-1 Recombinant
 Iroquois-class homeodomain protein IRX-1 Antibody
Also known as Iroquois-class homeodomain protein IRX-1 (Homeodomain protein IRXA1) (Iroquois homeobox protein 1).
IRX1: a member of the Iroquois homeobox protein family. Homeobox genes in this family are involved in pattern formation in the embryo. The gene product has been identified as a tumor suppressor in gastric (PMID: 21602894, 20440264) and head and neck cancers (PMID: 18559491). A pseud
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ogene of this gene is located on chromosome 13. [provided by RefSeq, Dec 2011]

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5p15.3
 IRX1 ELISA Kit
 IRX1 Recombinant
 IRX1 Antibody
 IRXA1 ELISA Kit
 IRXA1 Recombinant
 IRXA1 Antibody
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Iroquois-class homeodomain protein irx-1-A

 Iroquois-class homeodomain protein irx-1-A ELISA Kit
 Iroquois-class homeodomain protein irx-1-A Recombinant
 Iroquois-class homeodomain protein irx-1-A Antibody
Also known as Iroquois-class homeodomain protein irx-1-A (Iroquois homeobox protein 1-A) (Xiro-1) (Xiro1).
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precursor state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a tra
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nscriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development.
 irx1-a ELISA Kit
 irx1-a Recombinant
 irx1-a Antibody
 iro1 ELISA Kit
 iro1 Recombinant
 iro1 Antibody
 iro1-a ELISA Kit
 iro1-a Recombinant
 iro1-a Antibody
 irx1 ELISA Kit
 irx1 Recombinant
 irx1 Antibody
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Iroquois-class homeodomain protein irx-1-B

 Iroquois-class homeodomain protein irx-1-B ELISA Kit
 Iroquois-class homeodomain protein irx-1-B Recombinant
 Iroquois-class homeodomain protein irx-1-B Antibody
Also known as Iroquois-class homeodomain protein irx-1-B (Iroquois homeobox protein 1-B).
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Acts early in neural plate development to induce expression of some but not all proneural genes, and specify a neural precurso
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r state. Also up-regulates repressors that prevent neuronal differentiation. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Acts primarily as a transcriptional repressor during neural development, and binds to the bmp4 promoter to repress gene expression and thus mediate down-regulation of bmp4 by wnt signaling. Controls multiple processes through bmp4-repression including neural plate development, neural crest specification and Spemann organizer development. Involved in the specification of the preplacodal field at the anterior border of the neural plate. Regulates the genetic cascade of interactions that are necessary for positioning the isthmus organizer and the formation of the midbrain-hindbrain boundary. Required during at least two stages of pronephros kidney development; during neurula stages, maintains transcription of key renal genes to define the size and identity of the pronephric anlage, probably in part through regulation of bmp-signaling. Subsequently required for proper formation of the intermediate tubule segment of the pronephros. Acts principally as a transcriptional activator during pronephros development ().
 irx1-b ELISA Kit
 irx1-b Recombinant
 irx1-b Antibody
 iro1-b ELISA Kit
 iro1-b Recombinant
 iro1-b Antibody
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Iroquois-class homeodomain protein IRX-2

 Iroquois-class homeodomain protein IRX-2 ELISA Kit
 Iroquois-class homeodomain protein IRX-2 Recombinant
 Iroquois-class homeodomain protein IRX-2 Antibody
Also known as Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2).
IRX2: Belongs to the TALE/IRO homeobox family

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5p15.33
 IRX2 ELISA Kit
 IRX2 Recombinant
 IRX2 Antibody
 IRXA2 ELISA Kit
 IRXA2 Recombinant
 IRXA2 Antibody
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Iroquois-class homeodomain protein IRX-3

 Iroquois-class homeodomain protein IRX-3 ELISA Kit
 Iroquois-class homeodomain protein IRX-3 Recombinant
 Iroquois-class homeodomain protein IRX-3 Antibody
Also known as Iroquois-class homeodomain protein IRX-3 (Homeodomain protein IRXB1) (Iroquois homeobox protein 3).
IRX3: Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed
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by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Belongs to the TALE/IRO homeobox family.

Protein type: DNA-binding

Cellular Component: axon; cytoplasm; nucleus

Biological Process: kidney development; mesoderm development; metanephros development; negative regulation of neuron differentiation; positive regulation of neuron differentiation
 Irx3 ELISA Kit
 Irx3 Recombinant
 Irx3 Antibody
 Irxb1 ELISA Kit
 Irxb1 Recombinant
 Irxb1 Antibody
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Iroquois-class homeodomain protein IRX-4

 Iroquois-class homeodomain protein IRX-4 ELISA Kit
 Iroquois-class homeodomain protein IRX-4 Recombinant
 Iroquois-class homeodomain protein IRX-4 Antibody
Also known as Iroquois-class homeodomain protein IRX-4 (Homeodomain protein IRXA3) (Iroquois homeobox protein 4).
IRX4: Likely to be an important mediator of ventricular differentiation during cardiac development. Belongs to the TALE/IRO homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5p15.3
 IRX4 ELISA Kit
 IRX4 Recombinant
 IRX4 Antibody
 IRXA3 ELISA Kit
 IRXA3 Recombinant
 IRXA3 Antibody
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Iroquois-class homeodomain protein irx-4-A

 Iroquois-class homeodomain protein irx-4-A ELISA Kit
 Iroquois-class homeodomain protein irx-4-A Recombinant
 Iroquois-class homeodomain protein irx-4-A Antibody
Also known as Iroquois-class homeodomain protein irx-4-A (Iroquois homeobox protein 4-A).
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephro
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s kidney development.
 irx4-a ELISA Kit
 irx4-a Recombinant
 irx4-a Antibody
 irx4 ELISA Kit
 irx4 Recombinant
 irx4 Antibody
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Iroquois-class homeodomain protein irx-4-B

 Iroquois-class homeodomain protein irx-4-B ELISA Kit
 Iroquois-class homeodomain protein irx-4-B Recombinant
 Iroquois-class homeodomain protein irx-4-B Antibody
Also known as Iroquois-class homeodomain protein irx-4-B (Iroquois homeobox protein 4-B).
Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephro
>>>
s kidney development ().
 irx4-b ELISA Kit
 irx4-b Recombinant
 irx4-b Antibody
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Iroquois-class homeodomain protein IRX-5

 Iroquois-class homeodomain protein IRX-5 ELISA Kit
 Iroquois-class homeodomain protein IRX-5 Recombinant
 Iroquois-class homeodomain protein IRX-5 Antibody
Also known as Iroquois-class homeodomain protein IRX-5 (Homeodomain protein IRX-2A) (Homeodomain protein IRXB2) (Iroquois homeobox protein 5).
IRX5: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina. Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development.
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Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12. Defects in IRX5 are the cause of Hamamy syndrome (HMMS). A sydrome characterized by severe hypertelorism, upslanting palpebral fissures, brachycephaly, abnormal ears, sloping shoulders, enamel hypoplasia, and osteopenia with repeated fractures. Additional features include myopia, mild to moderate sensorineural hearing loss, gonadal anomalies, and borderline intelligence. Belongs to the TALE/IRO homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 16q12.2

Biological Process: embryonic cranial skeleton morphogenesis; gonad development

Disease: Hamamy Syndrome
 IRX5 ELISA Kit
 IRX5 Recombinant
 IRX5 Antibody
 IRX2A ELISA Kit
 IRX2A Recombinant
 IRX2A Antibody
 IRXB2 ELISA Kit
 IRXB2 Recombinant
 IRXB2 Antibody
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Iroquois-class homeodomain protein IRX-6

 Iroquois-class homeodomain protein IRX-6 ELISA Kit
 Iroquois-class homeodomain protein IRX-6 Recombinant
 Iroquois-class homeodomain protein IRX-6 Antibody
Also known as Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6).
IRX6: Belongs to the TALE/IRO homeobox family.

Protein type: DNA-binding

Biological Process: detection of visible light; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; retinal bipolar neuron differentiation
 Irx6 ELISA Kit
 Irx6 Recombinant
 Irx6 Antibody
 Irxb3 ELISA Kit
 Irxb3 Recombinant
 Irxb3 Antibody
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