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Iterative polyketide synthase

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Iterative polyketide synthase; part of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent .

Below are the list of possible Iterative polyketide synthase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Iterative polyketide synthase afoE

 Iterative polyketide synthase afoE ELISA Kit
 Iterative polyketide synthase afoE Recombinant
 Iterative polyketide synthase afoE Antibody
Also known as Iterative polyketide synthase afoE (Asperfuranone biosynthesis protein B).
Iterative polyketide synthase; part of the gene cluster that mediates the biosynthesis of asperfuranone, a probable antitumor agent (PubMed:19199437). The polyketide synthase afoG is responsible for producing the 3,5-dimethyloctadienone moiety from acetyl-CoA, three malonyl-CoA, and two S-adenosyl methionin
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es (SAM) (PubMed:19199437). The 3,5-dimethyloctadienone moiety is then loaded onto the SAT domain of afoE and extended with four malonyl-CoA and one SAM, which leads to the formation of 2,4-dihydroxy-6-(5,7-dimethyl-2-oxo-trans-3-trans-5-nonadienyl)-3-methylbenzaldehyde (compound 2) after reductive release and aldol condensation (PubMed:19199437). AfoD is the next enzyme in the biosynthesis sequence and hydroxylates the side chain at the benzylic position of compound 2 (PubMed:19199437). After benzylic hydroxylation, a furan ring is formed after five-member ring hemiacetal formation and water elimination (PubMed:19199437). AfoF and afoC are proposed to oxidize the R-diketone proton and to reduce the unconjugated carbonyl group, respectively, to generate asperfuranone (PubMed:19199437). Since no intermediates could be isolated from afoF and afoC deletants, the sequence of these two enzymes is not fully understood (PubMed:19199437). Moreover, since afoC deletant still produces a small amount of asperfuranone, other endogenous oxidoreductases might catalyze the same reaction with much less efficiency (PubMed:19199437).
 afoE ELISA Kit
 afoE Recombinant
 afoE Antibody
 AN1034 ELISA Kit
 AN1034 Recombinant
 AN1034 Antibody
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Iterative polyketide synthase CazM

 Iterative polyketide synthase CazM ELISA Kit
 Iterative polyketide synthase CazM Recombinant
 Iterative polyketide synthase CazM Antibody
Polyketide synthase; part of the Caz gene cluster that mediates the biosynthesis of the azaphilones chaetoviridin A and chaetomugilin A (PubMed:26172141, PubMed:23072467). The substrate (S,E)-4-methyl-hex-2-enoyltriketide is transferred from the CazF acyl carrier protein domain to the CazM N-terminal acylcarrier protein (ACP) transacylase domain, and from there to the phosphopantetheinyl group of
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the CazM ACP domain, where it serves as a starter for the biosynthesis of cazaldehyde A, the precursor of chaetoviridin A and chaetomugilin A. During this process, CazM consumes malonyl-CoA, S-adenosyl-L-methionine and NADPH to catalyze four rounds of chain elongation, cyclization and ultimately NADPH-dependent product release (PubMed:26172141).
 cazM ELISA Kit
 cazM Recombinant
 cazM Antibody
 CHGG_07645 ELISA Kit
 CHGG_07645 Recombinant
 CHGG_07645 Antibody
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