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Kalirin

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Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Isoforms 1 and 7 are necessary for neuronal development and axonal outgrowth. Isoform 6 is required for dendritic spine formation.

Below are the list of possible Kalirin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Kalirin

 Kalirin ELISA Kit
 Kalirin Recombinant
 Kalirin Antibody
Also known as Kalirin (Huntingtin-associated protein-interacting protein) (PAM COOH-terminal interactor protein 10) (P-CIP10) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain).
kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF a
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ctivity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.

Protein type: CAMK group; EC 2.7.11.1; GEFs; GEFs, Rac/Rho; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family

Cellular Component: cell soma; neuron projection; perinuclear region of cytoplasm; postsynaptic density

Molecular Function: enzyme binding; guanyl-nucleotide exchange factor activity; protein binding; Rac guanyl-nucleotide exchange factor activity

Biological Process: adult locomotory behavior; axonogenesis; behavioral fear response; behavioral response to cocaine; habituation; lactation; maternal behavior; maternal process involved in parturition; memory; negative regulation of growth hormone secretion; nervous system development; neuromuscular junction development; positive regulation of GTPase activity; regulation of dendrite development; regulation of neuronal synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to mechanical stimulus; Rho protein signal transduction; smooth muscle cell migration; smooth muscle cell proliferation; social behavior
 Kalrn ELISA Kit
 Kalrn Recombinant
 Kalrn Antibody
 Duo ELISA Kit
 Duo Recombinant
 Duo Antibody
 Hapip ELISA Kit
 Hapip Recombinant
 Hapip Antibody
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