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Kallikrein

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CATALYTIC ACTIVITY: Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa or Leu-|-Xaa.

Below are the list of possible Kallikrein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Kallikrein-1

 Kallikrein-1 ELISA Kit
 Kallikrein-1 Recombinant
 Kallikrein-1 Antibody
Also known as Kallikrein-1 (Gamma-NGF) (Nerve growth factor gamma chain) (PS kallikrein) (Pancreatic kallikrein) (RGK-1) (rK-1) (Tissue kallikrein) (True tissue kallikrein) (True kallikrein).
a putative pancreatic kallikrein [RGD, Feb 2006]
 Ngfg ELISA Kit
 Ngfg Recombinant
 Ngfg Antibody
 Klk-1 ELISA Kit
 Klk-1 Recombinant
 Klk-1 Antibody
 Klk1 ELISA Kit
 Klk1 Recombinant
 Klk1 Antibody
Table BarTOPTable Bar
 

Kallikrein-10

 Kallikrein-10 ELISA Kit
 Kallikrein-10 Recombinant
 Kallikrein-10 Antibody
Also known as Kallikrein-10 (Normal epithelial cell-specific 1) (Protease serine-like 1).
KLK10: Has a tumor-suppressor role for NES1 in breast and prostate cancer. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide; Tumor suppressor

Chromosomal Location of Human Ortholog: 19q13

Molecular Function: serine-type peptidase activity
 KLK10 ELISA Kit
 KLK10 Recombinant
 KLK10 Antibody
 NES1 ELISA Kit
 NES1 Recombinant
 NES1 Antibody
 PRSSL1 ELISA Kit
 PRSSL1 Recombinant
 PRSSL1 Antibody
Table BarTOPTable Bar
 

Kallikrein-11

 Kallikrein-11 ELISA Kit
 Kallikrein-11 Recombinant
 Kallikrein-11 Antibody
Also known as Kallikrein-11 (Hippostasin) (Serine protease 20).
KLK11: Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the h
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uman protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Cellular Component: extracellular region; extracellular space
 Klk11 ELISA Kit
 Klk11 Recombinant
 Klk11 Antibody
 Prss20 ELISA Kit
 Prss20 Recombinant
 Prss20 Antibody
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Kallikrein-12

 Kallikrein-12 ELISA Kit
 Kallikrein-12 Recombinant
 Kallikrein-12 Antibody
Also known as Kallikrein-12 (Kallikrein-like protein 5) (KLK-L5).
KLK12: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.21.-; Protease; Secreted; Sec
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reted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Molecular Function: peptidase activity; serine-type peptidase activity

Biological Process: proteolysis
 KLK12 ELISA Kit
 KLK12 Recombinant
 KLK12 Antibody
 KLKL5 ELISA Kit
 KLKL5 Recombinant
 KLKL5 Antibody
 UNQ669/PRO1303 ELISA Kit
 UNQ669/PRO1303 Recombinant
 UNQ669/PRO1303 Antibody
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Kallikrein-13

 Kallikrein-13 ELISA Kit
 Kallikrein-13 Recombinant
 Kallikrein-13 Antibody
Also known as Kallikrein-13 (Kallikrein-like protein 4) (KLK-L4).
KLK13: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on c
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hromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide; Vesicle

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytoplasm; extracellular region; extracellular space

Molecular Function: hydrolase activity; protein binding; serine-type endopeptidase activity

Biological Process: protein processing
 KLK13 ELISA Kit
 KLK13 Recombinant
 KLK13 Antibody
 KLKL4 ELISA Kit
 KLKL4 Recombinant
 KLKL4 Antibody
Table BarTOPTable Bar
 

Kallikrein-14

 Kallikrein-14 ELISA Kit
 Kallikrein-14 Recombinant
 Kallikrein-14 Antibody
Also known as Kallikrein-14 (Glandular kallikrein KLK14) (mGK14) (Kallikrein related-peptidase 14).
KLK14: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through dire
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ct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase activity

Biological Process: epidermis morphogenesis; fertilization; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis
 Klk14 ELISA Kit
 Klk14 Recombinant
 Klk14 Antibody
 Gk14 ELISA Kit
 Gk14 Recombinant
 Gk14 Antibody
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Kallikrein-15

 Kallikrein-15 ELISA Kit
 Kallikrein-15 Recombinant
 Kallikrein-15 Antibody
Protease whose physiological substrate is not yet known.
 KLK15 ELISA Kit
 KLK15 Recombinant
 KLK15 Antibody
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Kallikrein-1E2

 Kallikrein-1E2 ELISA Kit
 Kallikrein-1E2 Recombinant
 Kallikrein-1E2 Antibody
Also known as Kallikrein-1E2 (Glandular kallikrein) (HPK).
KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.35; Protease
 KLK1E2 ELISA Kit
 KLK1E2 Recombinant
 KLK1E2 Antibody
Table BarTOPTable Bar
 

Kallikrein-2

 Kallikrein-2 ELISA Kit
 Kallikrein-2 Recombinant
 Kallikrein-2 Antibody
Also known as Kallikrein-2 (Glandular kallikrein-1) (hGK-1) (Tissue kallikrein-2).
KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.35; Protease

Chromosomal Location of Human Orth
>>>
olog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly
 KLK2 ELISA Kit
 KLK2 Recombinant
 KLK2 Antibody
Table BarTOPTable Bar
 

Kallikrein-4

 Kallikrein-4 ELISA Kit
 Kallikrein-4 Recombinant
 Kallikrein-4 Antibody
Also known as Kallikrein-4 (Enamel matrix serine proteinase 1) (Kallikrein-like protein 1) (KLK-L1) (Prostase) (Serine protease 17).
KLK4: Involved in enamel formation. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1). AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: EC
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3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.41

Molecular Function: protein binding

Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia1
 KLK4 ELISA Kit
 KLK4 Recombinant
 KLK4 Antibody
 EMSP1 ELISA Kit
 EMSP1 Recombinant
 EMSP1 Antibody
 PRSS17 ELISA Kit
 PRSS17 Recombinant
 PRSS17 Antibody
 PSTS ELISA Kit
 PSTS Recombinant
 PSTS Antibody
Table BarTOPTable Bar
 

Kallikrein-5

 Kallikrein-5 ELISA Kit
 Kallikrein-5 Recombinant
 Kallikrein-5 Antibody
Also known as Kallikrein-5 (Kallikrein-like protein 2) (KLK-L2) (Stratum corneum tryptic enzyme).
KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space

Molecular Function: peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: epidermis development; positive regulation of antibacterial pe
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ptide production; positive regulation of G-protein coupled receptor protein signaling pathway
 KLK5 ELISA Kit
 KLK5 Recombinant
 KLK5 Antibody
 SCTE ELISA Kit
 SCTE Recombinant
 SCTE Antibody
 UNQ570/PRO1132 ELISA Kit
 UNQ570/PRO1132 Recombinant
 UNQ570/PRO1132 Antibody
Table BarTOPTable Bar
 

Kallikrein-6

 Kallikrein-6 ELISA Kit
 Kallikrein-6 Recombinant
 Kallikrein-6 Antibody
Also known as Kallikrein-6 (Neurosin) (Protease M) (SP59) (Serine protease 18) (Serine protease 9) (Zyme).
KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involve
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d in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.-; Nucleolus; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; extracellular region; extracellular space; intercellular bridge; microtubule cytoskeleton; nuclear membrane; nucleoplasm

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: positive regulation of G-protein coupled receptor protein signaling pathway; protein processing
 KLK6 ELISA Kit
 KLK6 Recombinant
 KLK6 Antibody
 PRSS18 ELISA Kit
 PRSS18 Recombinant
 PRSS18 Antibody
 PRSS9 ELISA Kit
 PRSS9 Recombinant
 PRSS9 Antibody
Table BarTOPTable Bar
 

Kallikrein-7

 Kallikrein-7 ELISA Kit
 Kallikrein-7 Recombinant
 Kallikrein-7 Antibody
Also known as Kallikrein-7 (hK7) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE).
KLK7: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isofor
>>>
ms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.35; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region; extracellular space

Molecular Function: metalloendopeptidase activity; peptidase activity; serine-type peptidase activity

Biological Process: epidermis development; extracellular matrix disassembly; positive regulation of antibacterial peptide production
 KLK7 ELISA Kit
 KLK7 Recombinant
 KLK7 Antibody
 PRSS6 ELISA Kit
 PRSS6 Recombinant
 PRSS6 Antibody
 SCCE ELISA Kit
 SCCE Recombinant
 SCCE Antibody
Table BarTOPTable Bar
 

Kallikrein-8

 Kallikrein-8 ELISA Kit
 Kallikrein-8 Recombinant
 Kallikrein-8 Antibody
Also known as Kallikrein-8 (Brain serine protease 1) (Neuropsin) (NP) (Serine protease 19).
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisitio
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n and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury ().
 Klk8 ELISA Kit
 Klk8 Recombinant
 Klk8 Antibody
 Bsp1 ELISA Kit
 Bsp1 Recombinant
 Bsp1 Antibody
 Nrpn ELISA Kit
 Nrpn Recombinant
 Nrpn Antibody
 Prss19 ELISA Kit
 Prss19 Recombinant
 Prss19 Antibody
Table BarTOPTable Bar
 

Kallikrein-9

 Kallikrein-9 ELISA Kit
 Kallikrein-9 Recombinant
 Kallikrein-9 Antibody
Also known as Kallikrein-9 (Kallikrein-like protein 3) (KLK-L3).
KLK9: is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010]

Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal pe
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ptide

Chromosomal Location of Human Ortholog: 19q13.41
 KLK9 ELISA Kit
 KLK9 Recombinant
 KLK9 Antibody
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Kallikrein-like EII

 Kallikrein-like EII ELISA Kit
 Kallikrein-like EII Recombinant
 Kallikrein-like EII Antibody
Cleaves a kininogen analog to release bradykinin.
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Proteins Root Name Listing
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