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Kappa-theraphotoxin

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Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.

Below are the list of possible Kappa-theraphotoxin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Kappa-theraphotoxin-Cg1a 1

 Kappa-theraphotoxin-Cg1a 1 ELISA Kit
 Kappa-theraphotoxin-Cg1a 1 Recombinant
 Kappa-theraphotoxin-Cg1a 1 Antibody
Also known as Kappa-theraphotoxin-Cg1a 1 (Kappa-TRTX-Cg1a) (Jingzhaotoxin-11) (JZTX-11) (Jingzhaotoxin-XI) (JZTX-XI).
Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KC
>>>
ND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.
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Kappa-theraphotoxin-Cg1a 2

 Kappa-theraphotoxin-Cg1a 2 ELISA Kit
 Kappa-theraphotoxin-Cg1a 2 Recombinant
 Kappa-theraphotoxin-Cg1a 2 Antibody
Also known as Kappa-theraphotoxin-Cg1a 2 (Kappa-TRTX-Cg1a) (Jingzhaotoxin-11.2) (JZTX-11.2) (Jingzhaotoxin-XI.2) (JZTX-XI.2) (Peptide F4-13.64).
Inhibits voltage-gated potassium channels (Kv2.1/KCN
>>>
B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel.
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Kappa-theraphotoxin-Cg1a 3

 Kappa-theraphotoxin-Cg1a 3 ELISA Kit
 Kappa-theraphotoxin-Cg1a 3 Recombinant
 Kappa-theraphotoxin-Cg1a 3 Antibody
Also known as Kappa-theraphotoxin-Cg1a 3 (Kappa-TRTX-Cg1a) (Jingzhaotoxin-11.3) (JZTX-11.3) (Jingzhaotoxin-XI.3) (JZTX-XI.3) (Peptide F4-13.64).
Inhibits voltage-gated potassium channels (Kv2.1/KCN
>>>
B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel.
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Kappa-theraphotoxin-Cg1a 4

 Kappa-theraphotoxin-Cg1a 4 ELISA Kit
 Kappa-theraphotoxin-Cg1a 4 Recombinant
 Kappa-theraphotoxin-Cg1a 4 Antibody
Also known as Kappa-theraphotoxin-Cg1a 4 (Kappa-TRTX-Cg1a) (Jingzhaotoxin-11.4) (JZTX-11.4) (Jingzhaotoxin-XI.4) (JZTX-XI.4) (Peptide F4-13.64).
Inhibits voltage-gated potassium channels (Kv2.1/KCN
>>>
B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel.
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Kappa-theraphotoxin-Cg1a 5

 Kappa-theraphotoxin-Cg1a 5 ELISA Kit
 Kappa-theraphotoxin-Cg1a 5 Recombinant
 Kappa-theraphotoxin-Cg1a 5 Antibody
Also known as Kappa-theraphotoxin-Cg1a 5 (Kappa-TRTX-Cg1a) (Jingzhaotoxin-11.5) (JZTX-11.5) (Jingzhaotoxin-XI.5) (JZTX-XI.5) (Peptide F4-13.64).
Inhibits voltage-gated potassium channels (Kv2.1/KCN
>>>
B1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel.
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Kappa-theraphotoxin-Cg1b

 Kappa-theraphotoxin-Cg1b ELISA Kit
 Kappa-theraphotoxin-Cg1b Recombinant
 Kappa-theraphotoxin-Cg1b Antibody
Also known as Kappa-theraphotoxin-Cg1b (Kappa-TRTX-Cg1b) (Jingzhaotoxin-30) (JZTX-30).
Probable ion channel inhibitor.
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Kappa-theraphotoxin-Cg1c

 Kappa-theraphotoxin-Cg1c ELISA Kit
 Kappa-theraphotoxin-Cg1c Recombinant
 Kappa-theraphotoxin-Cg1c Antibody
Also known as Kappa-theraphotoxin-Cg1c (Kappa-TRTX-Cg1c) (Jingzhaotoxin-29) (JZTX-29) (Peptide F4-13.58).
Probable ion channel inhibitor.
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Kappa-theraphotoxin-Cg1d

 Kappa-theraphotoxin-Cg1d ELISA Kit
 Kappa-theraphotoxin-Cg1d Recombinant
 Kappa-theraphotoxin-Cg1d Antibody
Also known as Kappa-theraphotoxin-Cg1d (Kappa-TRTX-Cg1d) (Jingzhaotoxin-61) (JZTX-61).
Probable ion channel inhibitor.
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Kappa-theraphotoxin-Cg2a

 Kappa-theraphotoxin-Cg2a ELISA Kit
 Kappa-theraphotoxin-Cg2a Recombinant
 Kappa-theraphotoxin-Cg2a Antibody
Also known as Kappa-theraphotoxin-Cg2a (Kappa-TRTX-Cg2a) (Jingzhaotoxin-12) (Jingzhaotoxin-45) (JZTX-45) (Jingzhaotoxin-XII) (JZTX-XII) (Peptide F4-20.99).
Inhibits voltage-gated potassium channels
>>>
of the subtype Kv4.1/KCND1 with high affinity and shows weak effects on Kv4.2/KCND2 and Kv2.1/KCNB1 subtypes. The toxin modifies the gating behavior of the channel and may interact with the S3-S4 extracellular loop.
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Kappa-theraphotoxin-Cg2b

 Kappa-theraphotoxin-Cg2b ELISA Kit
 Kappa-theraphotoxin-Cg2b Recombinant
 Kappa-theraphotoxin-Cg2b Antibody
Also known as Kappa-theraphotoxin-Cg2b (Kappa-TRTX-Cg2b) (Jingzhaotoxin-46) (JZTX-46).
Probable ion channel inhibitor.
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Kappa-theraphotoxin-Cg3a 1

 Kappa-theraphotoxin-Cg3a 1 ELISA Kit
 Kappa-theraphotoxin-Cg3a 1 Recombinant
 Kappa-theraphotoxin-Cg3a 1 Antibody
Also known as Kappa-theraphotoxin-Cg3a 1 (Kappa-TRTX-Cg3a) (Jingzhaotoxin-4) (JZTX-4).
Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels.
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Kappa-theraphotoxin-Cg3a 2

 Kappa-theraphotoxin-Cg3a 2 ELISA Kit
 Kappa-theraphotoxin-Cg3a 2 Recombinant
 Kappa-theraphotoxin-Cg3a 2 Antibody
Also known as Kappa-theraphotoxin-Cg3a 2 (Kappa-TRTX-Cg3a) (Jingzhaotoxin-4.2) (JZTX-4.2).
Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels.
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Kappa-theraphotoxin-Gr1a

 Kappa-theraphotoxin-Gr1a ELISA Kit
 Kappa-theraphotoxin-Gr1a Recombinant
 Kappa-theraphotoxin-Gr1a Antibody
Also known as Kappa-theraphotoxin-Gr1a (Kappa-TRTX-Gr1a) (Hanatoxin-1) (HaTx1).
Inhibits Kv2.1/KCNB1 and Kv4.2/KCND2 voltage-gated potassium channels. Acts as a gating modifier by shifting channel
>>>
openings to more depolarized voltages and acts via the occupancy of multiple binding sites on the channel. The toxin binding sites are situated on the S3-S4 extracellular linker of the channel. At least two hanatoxin molecules can occupy the Kv2.1/KCNB1 channel, and maybe more (three or four). Can also inhibit calcium channels (Cav2.1/CACNA1A). Needs to partition into the membrane in order to bind to the channel.
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Kappa-theraphotoxin-Gr1b

 Kappa-theraphotoxin-Gr1b ELISA Kit
 Kappa-theraphotoxin-Gr1b Recombinant
 Kappa-theraphotoxin-Gr1b Antibody
Also known as Kappa-theraphotoxin-Gr1b (Kappa-TRTX-Gr1b) (Hanatoxin-2) (HaTx2).
Inhibitor of voltage-gated potassium channels. Inhibits Kv2.1/KCNB1 channels, by shifting activation of the channel t
>>>
o more depolarized voltages. The toxin binding sites may be situated on the S3-S4 extracellular linker of the channel. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. May need to partition into the membrane in order to bind to the channel. Antibacterial activity is not observed.
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Kappa-theraphotoxin-Gr2a

 Kappa-theraphotoxin-Gr2a ELISA Kit
 Kappa-theraphotoxin-Gr2a Recombinant
 Kappa-theraphotoxin-Gr2a Antibody
Also known as Kappa-theraphotoxin-Gr2a (Kappa-TRTX-Gr2a) (Toxin GsMTx-2) (MTx2).
Blocks mammalian Kv4.2/KCND2 and Kv4.3/KCND3 (). Blocks mechanosensitive ion channels in rat astrocytes, without hav
>>>
ing effect on whole-cell voltage-sensitive currents.
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Kappa-theraphotoxin-Gr2b

 Kappa-theraphotoxin-Gr2b ELISA Kit
 Kappa-theraphotoxin-Gr2b Recombinant
 Kappa-theraphotoxin-Gr2b Antibody
Also known as Kappa-theraphotoxin-Gr2b (Kappa-TRTX-Gr2b) (Voltage sensor toxin 2) (VSTX2).
Binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) and aff
>>>
ects channel gating.
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Kappa-theraphotoxin-Gr2c

 Kappa-theraphotoxin-Gr2c ELISA Kit
 Kappa-theraphotoxin-Gr2c Recombinant
 Kappa-theraphotoxin-Gr2c Antibody
Also known as Kappa-theraphotoxin-Gr2c (Kappa-TRTX-Gr2c) (GsAF II) (GsAFII) (Mechanotoxin-alpha).
Inhibits sodium channels Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.6/SCN8A, Nav1.7/SCN9A, pota
>>>
ssium channels Kv11.1/KCNH2, as well as high-voltage-gated calcium channels Cav1.2/CACNA1C. Also blocks mechanosensitive ion channels (also named stretch-activated channels or SACs) and the hypotonic cell swelling induced calcium increase associated with the activation of such channels. It can thus be useful in treating cardiac ventricular disturbances. Also induces analgesia in mammals. This analgesia is probably mediated by a non-opioid receptor related mechanism.
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Kappa-theraphotoxin-Gr3a

 Kappa-theraphotoxin-Gr3a ELISA Kit
 Kappa-theraphotoxin-Gr3a Recombinant
 Kappa-theraphotoxin-Gr3a Antibody
Also known as Kappa-theraphotoxin-Gr3a (Kappa-TRTX-Gr3a) (Voltage sensor toxin 1) (VsTx1).
Inhibits sodium channels Nav1.7/SCN9A and potassium channels Kv11.1/KCNH2. Also binds the voltage-sensor d
>>>
omain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) with very slow apparent binding kinetics and affects channel gating. Reaches its target by dynamically partitioning into anionic or zwitterionic headgroup lipid membranes. May bind to the open state of KvAP.
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Kappa-theraphotoxin-Gr4a

 Kappa-theraphotoxin-Gr4a ELISA Kit
 Kappa-theraphotoxin-Gr4a Recombinant
 Kappa-theraphotoxin-Gr4a Antibody
Also known as Kappa-theraphotoxin-Gr4a (Kappa-TRTX-Gr4a) (Voltage sensor toxin 3) (VSTX3).
Binds the voltage-sensor domain of the potassium channel KvAP (from the archaeon Aeropyrum pernix) and aff
>>>
ects channel gating.
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Kappa-theraphotoxin-Hm1a

 Kappa-theraphotoxin-Hm1a ELISA Kit
 Kappa-theraphotoxin-Hm1a Recombinant
 Kappa-theraphotoxin-Hm1a Antibody
Also known as Kappa-theraphotoxin-Hm1a (Kappa-TRTX-Hm1a) (Heteroscodratoxin-1) (HmTx1).
Inhibitor of voltage-gated potassium channels, which inhibits Kv2.1/KCNB1, Kv2.2/KCNB2, Kv4.1/KCND1, Kv4.2/KC
>>>
ND2 and Kv4.3/KCND3 potassium channels (PubMed:12065754). May act by shifting activation of the channel to more depolarized voltages. The toxin binding sites may be situated on the S3-S4 extracellular linker of the channel (PubMed:12065754). One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel (PubMed:12065754). May need to partition into the membrane in order to bind to the channel. Intracerebroventricular injection into mice induces convulsions, spasms, tremors, and death (PubMed:12065754). Specifically activates the voltage-gated sodium channel Nav1.1/SCN1A in somatosensory neurons to elicit acute pain and mechanical allodynia (PubMed:27281198). The toxin targets the S3b-S4 and S1-S2 loops of repeat IV of the channel to inhibit fast inactivation of Nav1.1/SCN1A, selectivity for Nav1.1/SCN1A depending on S1-S2 loops of repeat IV (PubMed:27281198).
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Kappa-theraphotoxin-Hm1b

 Kappa-theraphotoxin-Hm1b ELISA Kit
 Kappa-theraphotoxin-Hm1b Recombinant
 Kappa-theraphotoxin-Hm1b Antibody
Also known as Kappa-theraphotoxin-Hm1b (Kappa-TRTX-Hm1b).
Inhibitor of voltage-gated potassium channels, which inhibits Kv2.1/KCNB1, Kv2.2/KCNB2, Kv4.1/KCND1, Kv4.2/KCND2 and Kv4.3/KCND3 potassium
>>>
channels (). May act by shifting activation of the channel to more depolarized voltages (). The toxin binding sites may be situated on the S3-S4 extracellular linker of the channel (). Specifically activates the voltage-gated sodium channel Nav1.1/SCN1A in somatosensory neurons to elicit acute pain and mechanical allodynia (PubMed:27281198). The toxin targets the S3b-S4 and S1-S2 loops of repeat IV of the channel to inhibit fast inactivation of Nav1.1/SCN1A, selectivity for Nav1.1/SCN1A depending on S1-S2 loops of repeat IV (PubMed:27281198).
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Kappa-theraphotoxin-Hm2a

 Kappa-theraphotoxin-Hm2a ELISA Kit
 Kappa-theraphotoxin-Hm2a Recombinant
 Kappa-theraphotoxin-Hm2a Antibody
Also known as Kappa-theraphotoxin-Hm2a (Kappa-TRTX-Hm2a) (Heteroscodratoxin-2) (HmTx2).
Inhibitor of voltage-gated potassium channels. It specifically inhibits Kv2.1/KCNB1 channels.
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Kappa-theraphotoxin-Pg1a

 Kappa-theraphotoxin-Pg1a ELISA Kit
 Kappa-theraphotoxin-Pg1a Recombinant
 Kappa-theraphotoxin-Pg1a Antibody
Also known as Kappa-theraphotoxin-Pg1a (Kappa-TRTX-Pg1a) (Guangxitoxin-1E) (GxTx1E).
Gating modifier of Kv2.1/KCNB1 (IC50=5.1 nM), Kv2.2/KCNB2 and Kv4.3/KCND3 channels (IC50=39 nM). Acts by shiftin
>>>
g the channel activation to more depolarized potentials by stabilizing the resting conformation of the voltage sensor. It completely inhibits opening of the Kv2.1/KCNB1 channel at negative membrane voltages and dramatically shifts channel activation to positive voltages. May act by partitioning into lipid membranes and then by binding the voltage sensor paddle of the channel from a place within the membrane.
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Kappa-theraphotoxin-Pg1b

 Kappa-theraphotoxin-Pg1b ELISA Kit
 Kappa-theraphotoxin-Pg1b Recombinant
 Kappa-theraphotoxin-Pg1b Antibody
Also known as Kappa-theraphotoxin-Pg1b (Kappa-TRTX-Pg1b) (Guangxitoxin-1D) (GxTX-1D).
Gating modifier of Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels.
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Kappa-theraphotoxin-Pg2a

 Kappa-theraphotoxin-Pg2a ELISA Kit
 Kappa-theraphotoxin-Pg2a Recombinant
 Kappa-theraphotoxin-Pg2a Antibody
Also known as Kappa-theraphotoxin-Pg2a (Kappa-TRTX-Pg2a) (Guangxitoxin-2) (GxTX-2).
Gating modifier of Kv2.1/KCNB1 channels.
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Kappa-theraphotoxin-Ps1a

 Kappa-theraphotoxin-Ps1a ELISA Kit
 Kappa-theraphotoxin-Ps1a Recombinant
 Kappa-theraphotoxin-Ps1a Antibody
Also known as Kappa-theraphotoxin-Ps1a (Kappa-TRTX-Ps1a) (PaTX1) (Phrixotoxin-1).
Potently blocks A-type potassium currents. Specifically blocks Kv4.2/KCND2 and Kv4.3/KCND3 channels by altering the
>>>
gating properties of these channels.
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Kappa-theraphotoxin-Ps1b

 Kappa-theraphotoxin-Ps1b ELISA Kit
 Kappa-theraphotoxin-Ps1b Recombinant
 Kappa-theraphotoxin-Ps1b Antibody
Also known as Kappa-theraphotoxin-Ps1b (Kappa-TRTX-Ps1b) (PaTX2) (Phrixotoxin-2).
Blocks mechanosensitive ion channels in rat astrocytes, without having effect on whole-cell voltage-sensitive curre
>>>
nts (). Potently blocks A-type potassium currents. Specifically blocks Kv4.2/KCND2 and Kv4.3/KCND3 channels by altering the gating properties of these channels.
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Kappa-theraphotoxin-Sc1a

 Kappa-theraphotoxin-Sc1a ELISA Kit
 Kappa-theraphotoxin-Sc1a Recombinant
 Kappa-theraphotoxin-Sc1a Antibody
Also known as Kappa-theraphotoxin-Sc1a (Kappa-TRTX-Sc1a) (Stromatoxin-1) (ScTx1).
Acts as a gating-modifier to inhibit voltage-gated potassium channels. It inhibits delayed Kv2.1/KCNB1 (IC50 is 12.
>>>
7 nM), Kv2.1/Kv9.3 (IC50 is 7.2 nM) (KCNB1/KCNS3), Kv2.2/KCNB2 (IC50 is 21.4 nM), and transient Kv4.2/KCND2 (IC50 is 1.2 nM) channels.
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Kappa-theraphotoxin-Scg1a

 Kappa-theraphotoxin-Scg1a ELISA Kit
 Kappa-theraphotoxin-Scg1a Recombinant
 Kappa-theraphotoxin-Scg1a Antibody
Also known as Kappa-theraphotoxin-Scg1a (Kappa-TRTX-Scg1a) (Toxin SGTx1).
Reversibly inhibits potassium currents in oocytes expressing Kv2.1/KCNB1 channels. Acts by shifting activation of the chann
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el to more depolarized voltages. The toxin may bind to the S3b-S4 helices of the voltage sensor paddle. One, two, three or four toxin molecules may bind the Kv2.1/KCNB1 channel. Partitions into the bilayer membrane, where it stabilizes at the water/membrane interface.
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Kappa-theraphotoxin-Tb1a

 Kappa-theraphotoxin-Tb1a ELISA Kit
 Kappa-theraphotoxin-Tb1a Recombinant
 Kappa-theraphotoxin-Tb1a Antibody
Also known as Kappa-theraphotoxin-Tb1a (Kappa-TRTX-Tb1a) (Theraphotoxin-1) (TlTx1).
Blocks Kv4.2/KCND2 voltage-gated potassium channels (IC50 is 193.0 nM) by shifting the voltage-dependence of chan
>>>
nel activation to more depolarized potentials. The toxin is thought to bind to the S3-S4 linker region of the voltage sensor domain.
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Kappa-theraphotoxin-Tb1b

 Kappa-theraphotoxin-Tb1b ELISA Kit
 Kappa-theraphotoxin-Tb1b Recombinant
 Kappa-theraphotoxin-Tb1b Antibody
Also known as Kappa-theraphotoxin-Tb1b (Kappa-TRTX-Tb1b) (Theraphotoxin-2) (TlTx2).
Low-affinity blocker of Kv4.2/KCND2 voltage-gated potassium channels. Is presumed to shift the voltage-dependence
>>>
of channel activation to more depolarized potentials and to bind to the S3-S4 linker region of the voltage sensor domain.
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Kappa-theraphotoxin-Tb1c

 Kappa-theraphotoxin-Tb1c ELISA Kit
 Kappa-theraphotoxin-Tb1c Recombinant
 Kappa-theraphotoxin-Tb1c Antibody
Also known as Kappa-theraphotoxin-Tb1c (Kappa-TRTX-Tb1c) (Theraphotoxin-3) (TlTx3).
Blocks Kv4.2/KCND2 voltage-gated potassium channels probably by shifting the voltage-dependence of channel activa
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tion to more depolarized potentials and by binding to the S3-S4 linker region of the voltage sensor domain.
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