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Kelch-like ECH-associated protein

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Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).

Below are the list of possible Kelch-like ECH-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Kelch-like ECH-associated protein 1

 Kelch-like ECH-associated protein 1 ELISA Kit
 Kelch-like ECH-associated protein 1 Recombinant
 Kelch-like ECH-associated protein 1 Antibody
Also known as Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2).
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxify
>>>
ing enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome ().
 KEAP1 ELISA Kit
 KEAP1 Recombinant
 KEAP1 Antibody
 INRF2 ELISA Kit
 INRF2 Recombinant
 INRF2 Antibody
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