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KH domain-containing, RNA-binding, signal transduction-associated protein

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Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species. RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (By similarity). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner. Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 .

Below are the list of possible KH domain-containing, RNA-binding, signal transduction-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

KH domain-containing, RNA-binding, signal transduction-associated protein 1

 KH domain-containing, RNA-binding, signal transduction-associated protein 1 ELISA Kit
 KH domain-containing, RNA-binding, signal transduction-associated protein 1 Recombinant
 KH domain-containing, RNA-binding, signal transduction-associated protein 1 Antibody
Also known as KH domain-containing, RNA-binding, signal transduction-associated protein 1 (GAP-associated tyrosine phosphoprotein p62) (Src-associated in mitosis 68 kDa protein) (Sam68) (p21 Ras GTPase-activating protein-associated p62) (p68).
KHDRBS1: a nuclear RNA-binding protein. May be involved in slicing and mRNA transport. Associates with src in mitosis. Binds to RNA via a heteronuclear r
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ibonucleoprotein K homology domain. Exerts functionally separable effects on cell proliferation and survival, dependent on its ability to bind specifically to RNA.

Protein type: RNA-binding

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus

Molecular Function: poly(A) binding; poly(U) binding; protein binding; protein complex binding; RNA binding; SH3 domain binding; SH3/SH2 adaptor activity

Biological Process: cell surface receptor linked signal transduction; negative regulation of transcription, DNA-dependent; positive regulation of RNA export from nucleus; positive regulation of translational initiation; regulation of nuclear mRNA splicing, via spliceosome; regulation of RNA export from nucleus
 Khdrbs1 ELISA Kit
 Khdrbs1 Recombinant
 Khdrbs1 Antibody
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KH domain-containing, RNA-binding, signal transduction-associated protein 2

 KH domain-containing, RNA-binding, signal transduction-associated protein 2 ELISA Kit
 KH domain-containing, RNA-binding, signal transduction-associated protein 2 Recombinant
 KH domain-containing, RNA-binding, signal transduction-associated protein 2 Antibody
RNA-binding protein that plays a role in the regulation of alternative splicing.
 khdrbs2 ELISA Kit
 khdrbs2 Recombinant
 khdrbs2 Antibody
 zgc:153588 ELISA Kit
 zgc:153588 Recombinant
 zgc:153588 Antibody
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KH domain-containing, RNA-binding, signal transduction-associated protein 3

 KH domain-containing, RNA-binding, signal transduction-associated protein 3 ELISA Kit
 KH domain-containing, RNA-binding, signal transduction-associated protein 3 Recombinant
 KH domain-containing, RNA-binding, signal transduction-associated protein 3 Antibody
Also known as KH domain-containing, RNA-binding, signal transduction-associated protein 3 (RNA-binding protein Etoile) (Sam68-like mammalian protein 2) (SLM-2).
KHDRBS3: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enh
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ancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Belongs to the KHDRBS family. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA binding; single-stranded RNA binding

Biological Process: mRNA processing; positive regulation of RNA splicing; regulation of nuclear mRNA splicing, via spliceosome
 Khdrbs3 ELISA Kit
 Khdrbs3 Recombinant
 Khdrbs3 Antibody
 Salp ELISA Kit
 Salp Recombinant
 Salp Antibody
 Slm2 ELISA Kit
 Slm2 Recombinant
 Slm2 Antibody
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