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Kinase D-interacting substrate

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Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.

Below are the list of possible Kinase D-interacting substrate products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Kinase D-interacting substrate of 220 kDa

 Kinase D-interacting substrate of 220 kDa ELISA Kit
 Kinase D-interacting substrate of 220 kDa Recombinant
 Kinase D-interacting substrate of 220 kDa Antibody
Also known as Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein).
KIDINS220: Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transdu
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ction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin- mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit

Cellular Component: cytosol; late endosome; membrane; protein complex

Molecular Function: PDZ domain binding; protein binding; protein kinase binding; protein kinase regulator activity

Biological Process: activation of MAPKK activity; dendrite morphogenesis; in utero embryonic development
 Kidins220 ELISA Kit
 Kidins220 Recombinant
 Kidins220 Antibody
 Arms ELISA Kit
 Arms Recombinant
 Arms Antibody
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