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KN motif and ankyrin repeat domain-containing protein

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Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Below are the list of possible KN motif and ankyrin repeat domain-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

KN motif and ankyrin repeat domain-containing protein 1

 KN motif and ankyrin repeat domain-containing protein 1 ELISA Kit
 KN motif and ankyrin repeat domain-containing protein 1 Recombinant
 KN motif and ankyrin repeat domain-containing protein 1 Antibody
Also known as KN motif and ankyrin repeat domain-containing protein 1 (Ankyrin repeat domain-containing protein 15) (Kidney ankyrin repeat-containing protein).
ANKRD15: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity; the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia; the function may depend o
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n the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma. Defects in KANK1 are the cause of cerebral palsy spastic quadriplegic type 2 (CPSQ2). A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of mental retardation. Neuroimaging shows brain atrophy and ventriculomegaly. 2 isoforms of the human protein are produced by alternative promoter.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 9p24.3

Cellular Component: plasma membrane

Molecular Function: beta-catenin binding; protein binding

Biological Process: negative regulation of actin filament polymerization; negative regulation of cell migration; negative regulation of insulin receptor signaling pathway; negative regulation of Rho protein signal transduction; positive regulation of Wnt receptor signaling pathway

Disease: Cerebral Palsy, Spastic Quadriplegic, 2
 KANK1 ELISA Kit
 KANK1 Recombinant
 KANK1 Antibody
 ANKRD15 ELISA Kit
 ANKRD15 Recombinant
 ANKRD15 Antibody
 KANK ELISA Kit
 KANK Recombinant
 KANK Antibody
 KIAA0172 ELISA Kit
 KIAA0172 Recombinant
 KIAA0172 Antibody
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KN motif and ankyrin repeat domain-containing protein 2

 KN motif and ankyrin repeat domain-containing protein 2 ELISA Kit
 KN motif and ankyrin repeat domain-containing protein 2 Recombinant
 KN motif and ankyrin repeat domain-containing protein 2 Antibody
Also known as KN motif and ankyrin repeat domain-containing protein 2 (Ankyrin repeat domain-containing protein 25).
ANKRD25: a mammalian growth regulatory protein containing five Ankyrin repeats, common protein-protein interaction motifs. Ankyrin repeats are found in proteins with diverse functions including transcriptional initiators, cell-cycle regulators, cytoskeletal, and ion transporters.
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Three alternatively spliced isoforms have been described.

Protein type: Transcription regulation

Cellular Component: cytoplasm; mitochondrion

Biological Process: negative regulation of cell proliferation; negative regulation of estrogen receptor signaling pathway; negative regulation of programmed cell death; negative regulation of stress fiber formation; negative regulation of transcription from RNA polymerase II promoter
 Kank2 ELISA Kit
 Kank2 Recombinant
 Kank2 Antibody
 Ankrd25 ELISA Kit
 Ankrd25 Recombinant
 Ankrd25 Antibody
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KN motif and ankyrin repeat domain-containing protein 3

 KN motif and ankyrin repeat domain-containing protein 3 ELISA Kit
 KN motif and ankyrin repeat domain-containing protein 3 Recombinant
 KN motif and ankyrin repeat domain-containing protein 3 Antibody
Also known as KN motif and ankyrin repeat domain-containing protein 3 (Ankyrin repeat domain-containing protein 47).
ANKRD47: May be involved in the control of cytoskeleton formation by regulating actin polymerization. 2 isoforms of the human protein are produced by alternative splicing.

Cellular Component: cytoplasm

Biological Process: negative regulation of stress fiber formation
 Kank3 ELISA Kit
 Kank3 Recombinant
 Kank3 Antibody
 Ankrd47 ELISA Kit
 Ankrd47 Recombinant
 Ankrd47 Antibody
 D17Ertd288e ELISA Kit
 D17Ertd288e Recombinant
 D17Ertd288e Antibody
 Ng28 ELISA Kit
 Ng28 Recombinant
 Ng28 Antibody
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KN motif and ankyrin repeat domain-containing protein 4

 KN motif and ankyrin repeat domain-containing protein 4 ELISA Kit
 KN motif and ankyrin repeat domain-containing protein 4 Recombinant
 KN motif and ankyrin repeat domain-containing protein 4 Antibody
Also known as KN motif and ankyrin repeat domain-containing protein 4 (Ankyrin repeat domain-containing protein 38).
KANK4: May be involved in the control of cytoskeleton formation by regulating actin polymerization. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Cellular Component: cytoplasm

Biological Process: negative
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regulation of stress fiber formation
 Kank4 ELISA Kit
 Kank4 Recombinant
 Kank4 Antibody
 Ankrd38 ELISA Kit
 Ankrd38 Recombinant
 Ankrd38 Antibody
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