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Krueppel-like factor

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Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.

Below are the list of possible Krueppel-like factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Krueppel-like factor 1

 Krueppel-like factor 1 ELISA Kit
 Krueppel-like factor 1 Recombinant
 Krueppel-like factor 1 Antibody
Also known as Krueppel-like factor 1 (Erythroid krueppel-like transcription factor) (EKLF).
KLF1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, i
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t binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. Defects in KLF1 are the cause of congenital dyserythropoietic anemia type 4 (CDA4). It is a blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nuclear chromatin; nucleus

Molecular Function: transcription factor activity

Biological Process: erythrocyte differentiation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent

Disease: Anemia, Congenital Dyserythropoietic, Type Iv; Blood Group--lutheran Inhibitor; Fetal Hemoglobin Quantitative Trait Locus 6
 KLF1 ELISA Kit
 KLF1 Recombinant
 KLF1 Antibody
 EKLF ELISA Kit
 EKLF Recombinant
 EKLF Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 10

 Krueppel-like factor 10 ELISA Kit
 Krueppel-like factor 10 Recombinant
 Krueppel-like factor 10 Antibody
Also known as Krueppel-like factor 10 (EGR-alpha) (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1).
KLF10: Transcriptional repressor involved in the regulation of cell growth. Inhibits cell growth. Binds to the consensus sequence 5'-GGTGTG-3'. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 8q22.2 >>>
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Cellular Component: nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: cell proliferation; cell-cell signaling; cellular response to starvation; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; skeletal development; transforming growth factor beta receptor signaling pathway
 KLF10 ELISA Kit
 KLF10 Recombinant
 KLF10 Antibody
 TIEG ELISA Kit
 TIEG Recombinant
 TIEG Antibody
 TIEG1 ELISA Kit
 TIEG1 Recombinant
 TIEG1 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 11

 Krueppel-like factor 11 ELISA Kit
 Krueppel-like factor 11 Recombinant
 Krueppel-like factor 11 Antibody
Also known as Krueppel-like factor 11 (TGFB-inducible early growth response protein 2b) (Transforming growth factor-beta-inducible early growth response protein 3) (TGFB-inducible early growth response protein 3) (TIEG-3).
TIEG2: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Defects in KLF11 are the cause of maturity-onset diabetes of the young type
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7 (MODY7). MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Cellular Component: nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; hemopoiesis; negative regulation of cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis
 Klf11 ELISA Kit
 Klf11 Recombinant
 Klf11 Antibody
 Tieg2b ELISA Kit
 Tieg2b Recombinant
 Tieg2b Antibody
 Tieg3 ELISA Kit
 Tieg3 Recombinant
 Tieg3 Antibody
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Krueppel-like factor 12

 Krueppel-like factor 12 ELISA Kit
 Krueppel-like factor 12 Recombinant
 Krueppel-like factor 12 Antibody
Also known as Krueppel-like factor 12 (Transcriptional repressor AP-2rep).
KLF12: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein;
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DNA-binding; Membrane protein, integral

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent
 Klf12 ELISA Kit
 Klf12 Recombinant
 Klf12 Antibody
 Ap2rep ELISA Kit
 Ap2rep Recombinant
 Ap2rep Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 13

 Krueppel-like factor 13 ELISA Kit
 Krueppel-like factor 13 Recombinant
 Krueppel-like factor 13 Antibody
Also known as Krueppel-like factor 13 (Basic transcription element-binding protein 3) (BTE-binding protein 3) (Erythroid transcription factor FKLF-2) (RANTES factor of late activated T-lymphocytes 1) (RFLAT-1) (Transcription factor BTEB3).
KLF13: Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DN
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A-binding

Molecular Function: DNA binding

Biological Process: negative regulation of cell proliferation; negative regulation of erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
 Klf13 ELISA Kit
 Klf13 Recombinant
 Klf13 Antibody
 Bteb3 ELISA Kit
 Bteb3 Recombinant
 Bteb3 Antibody
 Fklf2 ELISA Kit
 Fklf2 Recombinant
 Fklf2 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 14

 Krueppel-like factor 14 ELISA Kit
 Krueppel-like factor 14 Recombinant
 Krueppel-like factor 14 Antibody
KLF14: a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulat
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or SIN3A and histone deacetylase 2. [provided by RefSeq, Nov 2009]

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Molecular Function: chromatin binding; DNA binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter
 Klf14 ELISA Kit
 Klf14 Recombinant
 Klf14 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 15

 Krueppel-like factor 15 ELISA Kit
 Krueppel-like factor 15 Recombinant
 Krueppel-like factor 15 Antibody
Also known as Krueppel-like factor 15 (Cardiovascular Krueppel-like factor).
KLF15: Transcriptional activator. Binds to the GA element of the CLCNKA promoter. Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Cellular Component: nucleus

Molecular Function: DNA binding; protein binding; tra
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nscription factor activity

Biological Process: cardiac muscle hypertrophy; glial cell differentiation; glucose transport; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression
 Klf15 ELISA Kit
 Klf15 Recombinant
 Klf15 Antibody
 Cklf ELISA Kit
 Cklf Recombinant
 Cklf Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 16

 Krueppel-like factor 16 ELISA Kit
 Krueppel-like factor 16 Recombinant
 Krueppel-like factor 16 Antibody
Also known as Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Dopamine receptor-regulating factor) (Transcription factor BTEB4).
KLF16: Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain. Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding

Molecular Function: DNA binding; transcription factor activity

Biological Process: dopamine receptor signaling pathway; negative re
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gulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
 Klf16 ELISA Kit
 Klf16 Recombinant
 Klf16 Antibody
 Bteb4 ELISA Kit
 Bteb4 Recombinant
 Bteb4 Antibody
 Drrf ELISA Kit
 Drrf Recombinant
 Drrf Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 17

 Krueppel-like factor 17 ELISA Kit
 Krueppel-like factor 17 Recombinant
 Krueppel-like factor 17 Antibody
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays im
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portant roles in spermatid differentiation and oocyte development ().
 KLF17 ELISA Kit
 KLF17 Recombinant
 KLF17 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 2

 Krueppel-like factor 2 ELISA Kit
 Krueppel-like factor 2 Recombinant
 Krueppel-like factor 2 Antibody
Also known as Krueppel-like factor 2 (Lung krueppel-like factor).
KLF2: Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding

Cellular Component: nucleus

Molecular Function: DNA binding; protein binding; sequence-specific DNA
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binding; transcription factor activity

Biological Process: cell morphogenesis; erythrocyte homeostasis; erythrocyte maturation; in utero embryonic development; multicellular organism growth; negative regulation of interleukin-6 production; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic
 Klf2 ELISA Kit
 Klf2 Recombinant
 Klf2 Antibody
 Lklf ELISA Kit
 Lklf Recombinant
 Lklf Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 3

 Krueppel-like factor 3 ELISA Kit
 Krueppel-like factor 3 Recombinant
 Krueppel-like factor 3 Antibody
Also known as Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2).
KLF3: Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-bin
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ding; Transcription factor

Chromosomal Location of Human Ortholog: 4p14

Molecular Function: protein binding

Biological Process: multicellular organismal development
 KLF3 ELISA Kit
 KLF3 Recombinant
 KLF3 Antibody
 BKLF ELISA Kit
 BKLF Recombinant
 BKLF Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 4

 Krueppel-like factor 4 ELISA Kit
 Krueppel-like factor 4 Recombinant
 Krueppel-like factor 4 Antibody
Also known as Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor).
KLF4: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of
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the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain). Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: protein binding

Biological Process: fat cell differentiation; inhibition of NF-kappaB transcription factor; mesodermal cell fate determination; negative regulation of caspase activity; negative regulation of cell proliferation; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-8 biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cellular protein metabolic process; positive regulation of hemoglobin biosynthetic process; positive regulation of nitric oxide biosynthetic process; positive regulation of protein metabolic process; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; post-embryonic hemopoiesis; regulation of cell differentiation; somatic stem cell maintenance; stem cell maintenance; transcription from RNA polymerase II promoter
 KLF4 ELISA Kit
 KLF4 Recombinant
 KLF4 Antibody
 EZF ELISA Kit
 EZF Recombinant
 EZF Antibody
 GKLF ELISA Kit
 GKLF Recombinant
 GKLF Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 5

 Krueppel-like factor 5 ELISA Kit
 Krueppel-like factor 5 Recombinant
 Krueppel-like factor 5 Antibody
Also known as Krueppel-like factor 5 (Basic transcription element-binding protein 2) (BTE-binding protein 2) (Colon krueppel-like factor) (GC-box-binding protein 2) (Intestinal-enriched krueppel-like factor) (Transcription factor BTEB2).
KLF5: Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 13q22.1

Cellular Component: cytoplasm; Golgi a
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pparatus; intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
 KLF5 ELISA Kit
 KLF5 Recombinant
 KLF5 Antibody
 BTEB2 ELISA Kit
 BTEB2 Recombinant
 BTEB2 Antibody
 CKLF ELISA Kit
 CKLF Recombinant
 CKLF Antibody
 IKLF ELISA Kit
 IKLF Recombinant
 IKLF Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 6

 Krueppel-like factor 6 ELISA Kit
 Krueppel-like factor 6 Recombinant
 Krueppel-like factor 6 Antibody
Also known as Krueppel-like factor 6 (B-cell-derived protein 1) (Core promoter element-binding protein) (GC-rich sites-binding factor GBF) (Proto-oncogene BCD1) (Suppressor of tumorigenicity 12 protein) (Transcription factor Zf9).
KLF6: Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development. Defects in KLF6 are a cause of gastric cancer (GASC); also called gastric cancer intestinal or stomach cancer. Gastric cancer is a malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the st
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omach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. Defects in KLF6 are a cause of prostate cancer (PC). Prostate cancer is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 10p15

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: positive regulation of transcription, DNA-dependent

Disease: Gastric Cancer; Prostate Cancer
 KLF6 ELISA Kit
 KLF6 Recombinant
 KLF6 Antibody
 BCD1 ELISA Kit
 BCD1 Recombinant
 BCD1 Antibody
 COPEB ELISA Kit
 COPEB Recombinant
 COPEB Antibody
 CPBP ELISA Kit
 CPBP Recombinant
 CPBP Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 7

 Krueppel-like factor 7 ELISA Kit
 Krueppel-like factor 7 Recombinant
 Krueppel-like factor 7 Antibody
KLF7: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding

Molecular Function: DNA binding; transcription factor activity

Biological Process: axon guidance; axonogenesis; dendrite morphog
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enesis; positive regulation of transcription, DNA-dependent
 Klf7 ELISA Kit
 Klf7 Recombinant
 Klf7 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 8

 Krueppel-like factor 8 ELISA Kit
 Krueppel-like factor 8 Recombinant
 Krueppel-like factor 8 Antibody
KLF8: Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK). Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor

Molecular Fun
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ction: DNA binding
 Klf8 ELISA Kit
 Klf8 Recombinant
 Klf8 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor 9

 Krueppel-like factor 9 ELISA Kit
 Krueppel-like factor 9 Recombinant
 Krueppel-like factor 9 Antibody
Also known as Krueppel-like factor 9 (Basic transcription element-binding protein 1) (BTE-binding protein 1) (GC-box-binding protein 1) (Transcription factor BTEB1).
KLF9: Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Belongs to the Sp1 C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 9q13

Cellular Component: cytoplasm; nucleoplasm; nucleus; pla
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sma membrane

Molecular Function: transcription factor activity

Biological Process: circadian rhythm; regulation of transcription from RNA polymerase II promoter
 KLF9 ELISA Kit
 KLF9 Recombinant
 KLF9 Antibody
 BTEB ELISA Kit
 BTEB Recombinant
 BTEB Antibody
 BTEB1 ELISA Kit
 BTEB1 Recombinant
 BTEB1 Antibody
Table BarTOPTable Bar
 

Krueppel-like factor luna

 Krueppel-like factor luna ELISA Kit
 Krueppel-like factor luna Recombinant
 Krueppel-like factor luna Antibody
Probable transcription factor that is required for cell differentiation (PubMed:14527717, PubMed:24915236). Essential for proper separation of the sister chromatids during early nuclear division cycles in the syncytial pre-blastoderm embryo (PubMed:24915236).
 luna ELISA Kit
 luna Recombinant
 luna Antibody
 CG33473 ELISA Kit
 CG33473 Recombinant
 CG33473 Antibody
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