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Large neutral amino acids transporter

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Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L-leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts.

Below are the list of possible Large neutral amino acids transporter products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Large neutral amino acids transporter small subunit 1

 Large neutral amino acids transporter small subunit 1 ELISA Kit
 Large neutral amino acids transporter small subunit 1 Recombinant
 Large neutral amino acids transporter small subunit 1 Antibody
Also known as Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter).
SLC7A5: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barri
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er, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc. Expression induced in quiescent peripheral blood lymphocytes after treatment with phorbol myristate acetate (PMA) and phytohemagglutinin (PHA). Expression and the uptake of leucine is stimulated in mononuclear, cytotrophoblast-like choriocarcinoma cells by combined treatment with PMA and calcium ionophore. Expressed abundantly in adult lung, liver, brain, skeletal muscle, placenta, bone marrow, testis, resting lymphocytes and monocytes, and in fetal liver. Weaker expression in thymus, cornea, retina, peripheral leukocytes, spleen, kidney, colon and lymph node. During gestation, expression in the placenta was significantly stronger at full-term than at the mid-trimester stage. Also expressed in all human tumor cell lines tested and in the astrocytic process of primary astrocytic gliomas. Expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco-2. Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 16q24.3

Cellular Component: cytoplasm; integral to plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane

Molecular Function: amino acid transmembrane transporter activity; antiporter activity; L-amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activity; peptide antigen binding

Biological Process: amino acid metabolic process; amino acid transport; leukocyte migration; neutral amino acid transport; transport
 SLC7A5 ELISA Kit
 SLC7A5 Recombinant
 SLC7A5 Antibody
 CD98LC ELISA Kit
 CD98LC Recombinant
 CD98LC Antibody
 LAT1 ELISA Kit
 LAT1 Recombinant
 LAT1 Antibody
 MPE16 ELISA Kit
 MPE16 Recombinant
 MPE16 Antibody
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Large neutral amino acids transporter small subunit 2

 Large neutral amino acids transporter small subunit 2 ELISA Kit
 Large neutral amino acids transporter small subunit 2 Recombinant
 Large neutral amino acids transporter small subunit 2 Antibody
Also known as Large neutral amino acids transporter small subunit 2 (4F2-LC5) (L-type amino acid transporter 2) (Solute carrier family 7 member 8).
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exch
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anger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
 SLC7A8 ELISA Kit
 SLC7A8 Recombinant
 SLC7A8 Antibody
 LAT2 ELISA Kit
 LAT2 Recombinant
 LAT2 Antibody
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Large neutral amino acids transporter small subunit 3

 Large neutral amino acids transporter small subunit 3 ELISA Kit
 Large neutral amino acids transporter small subunit 3 Recombinant
 Large neutral amino acids transporter small subunit 3 Antibody
Also known as Large neutral amino acids transporter small subunit 3 (L-type amino acid transporter 3) (Prostate cancer overexpressed gene 1 protein) (Solute carrier family 43 member 1).
SLC43A1: Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. Belongs to the SLC43A transporter (TC 2.A.1.44) family. 2 isoforms
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of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: amino acid transmembrane transporter activity; L-amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activity

Biological Process: amino acid transport; neutral amino acid transport
 SLC43A1 ELISA Kit
 SLC43A1 Recombinant
 SLC43A1 Antibody
 LAT3 ELISA Kit
 LAT3 Recombinant
 LAT3 Antibody
 PB39 ELISA Kit
 PB39 Recombinant
 PB39 Antibody
 POV1 ELISA Kit
 POV1 Recombinant
 POV1 Antibody
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Large neutral amino acids transporter small subunit 4

 Large neutral amino acids transporter small subunit 4 ELISA Kit
 Large neutral amino acids transporter small subunit 4 Recombinant
 Large neutral amino acids transporter small subunit 4 Antibody
Also known as Large neutral amino acids transporter small subunit 4 (L-type amino acid transporter 4) (Solute carrier family 43 member 2).
Sodium-, chloride, pH-independent high affinity transport of large neutral amino acids.
 SLC43A2 ELISA Kit
 SLC43A2 Recombinant
 SLC43A2 Antibody
 LAT4 ELISA Kit
 LAT4 Recombinant
 LAT4 Antibody
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