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Large proline-rich protein

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Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane .

Below are the list of possible Large proline-rich protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Large proline-rich protein BAG6

 Large proline-rich protein BAG6 ELISA Kit
 Large proline-rich protein BAG6 Recombinant
 Large proline-rich protein BAG6 Antibody
Also known as Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (BAG6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe).
BAT3: Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome. Participates in endoplasmic reticulum stress-induced apoptosis via its interaction with AIFM1/AIF by regulating
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AIFM1/AIF stability and preventing its degradation. Also required during spermatogenesis for synaptonemal complex assembly via its interaction with HSPA2, by inhibiting polyubiquitination and subsequent proteasomal degradation of HSPA2. Required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, may play a role in immuno-proteasomes to generate antigenic peptides via targeted degradation, thereby playing a role in antigen presentation in immune response. Key component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins and transfers them to ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Component of the BAT3 complex, at least composed of BAG6/BAT3, UBL4A and GET3/TRC35. Interacts with AIFM1, CTCFL, HSPA2 and p300/EP300. Interacts with ricin A chain. Interacts with L.pneumophila proteins Lpg2160 and LegU1. Interacts with NCR3. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cell cycle regulation; Chaperone; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; nucleoplasm; nucleus

Molecular Function: misfolded protein binding; polyubiquitin binding; protein binding; ribosome binding; ubiquitin protein ligase binding

Biological Process: brain development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; embryonic development; internal peptidyl-lysine acetylation; kidney development; lung development; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of proteolysis; protein stabilization; spermatogenesis; synaptonemal complex assembly; ubiquitin-dependent protein catabolic process
 BAG6 ELISA Kit
 BAG6 Recombinant
 BAG6 Antibody
 BAT3 ELISA Kit
 BAT3 Recombinant
 BAT3 Antibody
 G3 ELISA Kit
 G3 Recombinant
 G3 Antibody
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Large proline-rich protein bag6-A

 Large proline-rich protein bag6-A ELISA Kit
 Large proline-rich protein bag6-A Recombinant
 Large proline-rich protein bag6-A Antibody
Also known as Large proline-rich protein bag6-A (BCL2-associated athanogene 6) (HLA-B-associated transcript 3-A) (Protein Scythe).
Chaperone that plays a key role in various processes such as insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome
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. Key Component of the BAT3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. When nuclear, may also act as a component of some chromatin regulator complex (). Acts as a regulator of apoptosis.
 Bag6-a ELISA Kit
 Bag6-a Recombinant
 Bag6-a Antibody
 bat3-a ELISA Kit
 bat3-a Recombinant
 bat3-a Antibody
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Large proline-rich protein bag6-B

 Large proline-rich protein bag6-B ELISA Kit
 Large proline-rich protein bag6-B Recombinant
 Large proline-rich protein bag6-B Antibody
Also known as Large proline-rich protein bag6-B (BCL2-associated athanogene 6) (HLA-B-associated transcript 3-B).
Chaperone that plays a key role in various processes such as apoptosis, insertion of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane and regulation of chromatin. Acts in part by regulating stability of proteins and their degradation by the proteasome. Key
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component of the bag6/bat3 complex, a cytosolic multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. When nuclear, may also act as a component of some chromatin regulator complex.
 Bag6-b ELISA Kit
 Bag6-b Recombinant
 Bag6-b Antibody
 bat3-b ELISA Kit
 bat3-b Recombinant
 bat3-b Antibody
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