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Leucine-rich repeat and WD repeat-containing protein

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Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.

Below are the list of possible Leucine-rich repeat and WD repeat-containing protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Leucine-rich repeat and WD repeat-containing protein 1

 Leucine-rich repeat and WD repeat-containing protein 1 ELISA Kit
 Leucine-rich repeat and WD repeat-containing protein 1 Recombinant
 Leucine-rich repeat and WD repeat-containing protein 1 Antibody
Also known as Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA).
LRWD1: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 t
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rimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors. Belongs to the LRWD1 family.

Protein type: DNA replication; DNA-binding; Histone-binding

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: centric heterochromatin; kinetochore; nuclear origin of replication recognition complex; nucleus

Molecular Function: chromatin binding; methyl-CpG binding; methylated histone residue binding; protein binding

Biological Process: DNA replication initiation; establishment and/or maintenance of chromatin architecture
 LRWD1 ELISA Kit
 LRWD1 Recombinant
 LRWD1 Antibody
 CENP-33 ELISA Kit
 CENP-33 Recombinant
 CENP-33 Antibody
 ORCA ELISA Kit
 ORCA Recombinant
 ORCA Antibody
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