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Leukocyte-associated immunoglobulin-like receptor

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Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Below are the list of possible Leukocyte-associated immunoglobulin-like receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Leukocyte-associated immunoglobulin-like receptor 1

 Leukocyte-associated immunoglobulin-like receptor 1 ELISA Kit
 Leukocyte-associated immunoglobulin-like receptor 1 Recombinant
 Leukocyte-associated immunoglobulin-like receptor 1 Antibody
Also known as Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305).
LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associa
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ted inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: plasma membrane

Molecular Function: protein binding

Biological Process: regulation of immune response
 LAIR1 ELISA Kit
 LAIR1 Recombinant
 LAIR1 Antibody
 CD305 ELISA Kit
 CD305 Recombinant
 CD305 Antibody
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Leukocyte-associated immunoglobulin-like receptor 2

 Leukocyte-associated immunoglobulin-like receptor 2 ELISA Kit
 Leukocyte-associated immunoglobulin-like receptor 2 Recombinant
 Leukocyte-associated immunoglobulin-like receptor 2 Antibody
Also known as Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306).
LAIR-2: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Proc
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ess: regulation of immune response
 LAIR2 ELISA Kit
 LAIR2 Recombinant
 LAIR2 Antibody
 CD306 ELISA Kit
 CD306 Recombinant
 CD306 Antibody
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