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LIM domain kinase

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Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1) (By similarity).

Below are the list of possible LIM domain kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

LIM domain kinase 1

 LIM domain kinase 1 ELISA Kit
 LIM domain kinase 1 Recombinant
 LIM domain kinase 1 Antibody
Also known as LIM domain kinase 1 (LIMK-1).
LIMK1: a TKL kinase of the LISK family which mediates Rho signaling to cytoskeleton. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. May be involved in brain development. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes
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. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with slingshot 1. Overexpressed in prostate tumors and prostate and breast cancer cell lines; manipulation of activity correlates with invasiveness in breast and prostate cancer models. Located within the 7q11.2 amplicon associated with metastatic prostate cancer. Loss of one copy of LIMK1 is the likely cause of visuospatial cognition defects seen in small chromosomal deletions associated with dominant Williams-Beuren syndrome Three splice variant have been identified.

Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Cellular Component: cytoplasm; focal adhesion; Golgi apparatus; membrane; neuron projection; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: heat shock protein binding; protein heterodimerization activity

Biological Process: negative regulation of ubiquitin-protein ligase activity; positive regulation of actin filament bundle formation; positive regulation of axon extension; positive regulation of stress fiber formation; protein amino acid phosphorylation
 Limk1 ELISA Kit
 Limk1 Recombinant
 Limk1 Antibody
 Limk ELISA Kit
 Limk Recombinant
 Limk Antibody
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LIM domain kinase 2

 LIM domain kinase 2 ELISA Kit
 LIM domain kinase 2 Recombinant
 LIM domain kinase 2 Antibody
Also known as LIM domain kinase 2 (LIMK-2).
LIMK2: a TKL kinase of the LISK family that regulates actin dynamics. Contains two N-terminal LIM motifs. Phosphorylated and activated by PAK1 and ROCK, downstream effectors of Rho. Phosphorylates cofilin, inhibiting its actin-depolymerizing activity. May contributes to Rho-induced reorganization of the actin cytoskeleton. Two alternative splice varia
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nts have been identified.

Protein type: EC 2.7.11.1; Kinase, protein; LIMK subfamily; LISK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein serine/threonine kinase activity; signal transducer activity

Biological Process: phosphorylation
 LIMK2 ELISA Kit
 LIMK2 Recombinant
 LIMK2 Antibody
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