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Lovastatin diketide synthase

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Synthesizes the diketide sidechain of lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Catalyzes the synthesis of alpha-S-methylbutyrate using malonyl-coenzyme A, S-adenosyl-L-methionine and NADPH.

Below are the list of possible Lovastatin diketide synthase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Lovastatin diketide synthase LovF

 Lovastatin diketide synthase LovF ELISA Kit
 Lovastatin diketide synthase LovF Recombinant
 Lovastatin diketide synthase LovF Antibody
Also known as Lovastatin diketide synthase LovF (LDKS).
Synthesizes the diketide sidechain of lovastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Catalyzes the synthesis of alpha-S-methylbutyrate using malonyl-coenzyme A, S-adenosyl-L-methionine and NADPH.
 lovF ELISA Kit
 lovF Recombinant
 lovF Antibody
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Lovastatin diketide synthase mokB

 Lovastatin diketide synthase mokB ELISA Kit
 Lovastatin diketide synthase mokB Recombinant
 Lovastatin diketide synthase mokB Antibody
Also known as Lovastatin diketide synthase mokB (Monacolin K biosynthesis protein B).
Diketide synthase; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535). Monakolin K biosynthesis is performed in two stages (PubMed:19693441). The first stage is catalyzed by th
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e nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage completed by the action of deshydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutyric acid produced by the diketide synthase mokB (PubMed:19693441).
 mokB ELISA Kit
 mokB Recombinant
 mokB Antibody
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