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Lovastatin nonaketide synthase

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Synthesizes the nonaketide chain of lovastatin, an HMG-CoA reductase inhibitor.

Below are the list of possible Lovastatin nonaketide synthase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Lovastatin nonaketide synthase

 Lovastatin nonaketide synthase ELISA Kit
 Lovastatin nonaketide synthase Recombinant
 Lovastatin nonaketide synthase Antibody
Also known as Lovastatin nonaketide synthase (LNKS).
Synthesizes the nonaketide chain of lovastatin, an HMG-CoA reductase inhibitor.
 lovB ELISA Kit
 lovB Recombinant
 lovB Antibody
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Lovastatin nonaketide synthase mokA

 Lovastatin nonaketide synthase mokA ELISA Kit
 Lovastatin nonaketide synthase mokA Recombinant
 Lovastatin nonaketide synthase mokA Antibody
Also known as Lovastatin nonaketide synthase mokA (Monacolin K biosynthesis protein A).
Nonaketide synthase; part of the gene cluster that mediates the biosynthesis of monakolin K, also known as lovastatin, and which acts as a potent competitive inhibitor of HMG-CoA reductase (PubMed:18578535). Monakolin K biosynthesis is performed in two stages (PubMed:19693441). The first stage is catalyzed b
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y the nonaketide synthase mokA, which belongs to type I polyketide synthases and catalyzes the iterative nine-step formation of the polyketide (PubMed:18578535, PubMed:19693441). This PKS stage is completed by the action of deshydrogenase mokE, which catalyzes the NADPH-dependent reduction of the unsaturated tetra-, penta- and heptaketide intermediates that arise during the mokA-mediated biosynthesis of the nonaketide chain and leads to dihydromonacolin L (PubMed:19693441). Covalently bound dihydromonacolin L is released from mokA by the mokD esterase (). Conversion of dihydromonacolin L into monacolin L and then monacolin J is subsequently performed with the participation of molecular oxygen and P450 monoogygenase mokC (PubMed:19693441). Finally, mokF performs the conversion of monacoline J to monacoline K through the addition of the side-chain diketide moiety (2R)-2-methylbutyric acid produced by the diketide synthase mokB (PubMed:19693441).
 mokA ELISA Kit
 mokA Recombinant
 mokA Antibody
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