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Low-density lipoprotein receptor

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Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

Below are the list of possible Low-density lipoprotein receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Low-density lipoprotein receptor

 Low-density lipoprotein receptor ELISA Kit
 Low-density lipoprotein receptor Recombinant
 Low-density lipoprotein receptor Antibody
Also known as Low-density lipoprotein receptor (LDL receptor).
LDLR: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalizati
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on in uninfected cells. Defects in LDLR are the cause of familial hypercholesterolemia (FH); a common autosomal semi- dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL, and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma), tendons (xanthomas), and coronary arteries (atherosclerosis). Belongs to the LDLR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; coated pit; early endosome; endosome membrane; external side of plasma membrane; Golgi apparatus; integral to plasma membrane; late endosome; lysosome; membrane; plasma membrane; receptor complex

Molecular Function: clathrin heavy chain binding; glycoprotein binding; identical protein binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protease binding; protein binding; very-low-density lipoprotein receptor activity

Biological Process: cholesterol absorption; cholesterol homeostasis; cholesterol transport; endocytosis; lipid metabolic process; phospholipid transport; receptor-mediated endocytosis

Disease: Hypercholesterolemia, Familial
 LDLR ELISA Kit
 LDLR Recombinant
 LDLR Antibody
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Low-density lipoprotein receptor 1

 Low-density lipoprotein receptor 1 ELISA Kit
 Low-density lipoprotein receptor 1 Recombinant
 Low-density lipoprotein receptor 1 Antibody
Also known as Low-density lipoprotein receptor 1 (LDL receptor 1).
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
 ldlr-a ELISA Kit
 ldlr-a Recombinant
 ldlr-a Antibody
 ldlr1 ELISA Kit
 ldlr1 Recombinant
 ldlr1 Antibody
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Low-density lipoprotein receptor 2

 Low-density lipoprotein receptor 2 ELISA Kit
 Low-density lipoprotein receptor 2 Recombinant
 Low-density lipoprotein receptor 2 Antibody
Also known as Low-density lipoprotein receptor 2 (LDL receptor 2).
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
 ldlr-b ELISA Kit
 ldlr-b Recombinant
 ldlr-b Antibody
 ldlr2 ELISA Kit
 ldlr2 Recombinant
 ldlr2 Antibody
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