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Low density lipoprotein receptor adapter protein

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Below are the list of possible Low density lipoprotein receptor adapter protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Low density lipoprotein receptor adapter protein 1

 Low density lipoprotein receptor adapter protein 1 ELISA Kit
 Low density lipoprotein receptor adapter protein 1 Recombinant
 Low density lipoprotein receptor adapter protein 1 Antibody
Also known as Low density lipoprotein receptor adapter protein 1 (Autosomal recessive hypercholesterolemia protein homolog).
LDLRAP1: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and i
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nternalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Defects in LDLRAP1 are the cause of autosomal recessive hypercholesterolemia (ARH). ARH is a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. ARH has the clinical features of familial hypercholesterolemia (FH) homozygotes, including severely elevated plasma LDL cholesterol, tuberous and tendon xanthomata, and premature atherosclerosis. LDL receptor (LDLR) activity measured in skin fibroblasts is normal, as the LDL binding ability.

Cellular Component: AP-1 adaptor complex; AP-2 adaptor complex; axon; basal plasma membrane; cell; cytoplasm; cytosol; early endosome; internal side of plasma membrane; intracellular; neurofilament; recycling endosome

Molecular Function: beta-amyloid binding; clathrin binding; low-density lipoprotein receptor binding; phosphatidylinositol-4,5-bisphosphate binding; phosphotyrosine binding; protein binding; receptor binding; receptor signaling complex scaffold activity

Biological Process: amyloid precursor protein metabolic process; cholesterol homeostasis; positive regulation of receptor-mediated endocytosis; receptor internalization; receptor-mediated endocytosis; regulation of protein binding
 Ldlrap1 ELISA Kit
 Ldlrap1 Recombinant
 Ldlrap1 Antibody
 Arh ELISA Kit
 Arh Recombinant
 Arh Antibody
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Low density lipoprotein receptor adapter protein 1-A

 Low density lipoprotein receptor adapter protein 1-A ELISA Kit
 Low density lipoprotein receptor adapter protein 1-A Recombinant
 Low density lipoprotein receptor adapter protein 1-A Antibody
Also known as Low density lipoprotein receptor adapter protein 1-A (Autosomal recessive hypercholesterolemia protein homolog alpha) (ARH alpha) (xARH alpha) (Phosphotyrosine-binding protein) (Xcat4).
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutri
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ents during oogenesis.
 ldlrap1-a ELISA Kit
 ldlrap1-a Recombinant
 ldlrap1-a Antibody
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Low density lipoprotein receptor adapter protein 1-B

 Low density lipoprotein receptor adapter protein 1-B ELISA Kit
 Low density lipoprotein receptor adapter protein 1-B Recombinant
 Low density lipoprotein receptor adapter protein 1-B Antibody
Also known as Low density lipoprotein receptor adapter protein 1-B (Autosomal recessive hypercholesterolemia protein homolog beta) (ARH beta) (xARH beta).
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutrients during oogenesis.
 ldlrap1-b ELISA Kit
 ldlrap1-b Recombinant
 ldlrap1-b Antibody
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