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Low-density lipoprotein receptor-related protein

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May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin.

Below are the list of possible Low-density lipoprotein receptor-related protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Low-density lipoprotein receptor-related protein

 Low-density lipoprotein receptor-related protein ELISA Kit
 Low-density lipoprotein receptor-related protein Recombinant
 Low-density lipoprotein receptor-related protein Antibody
Also known as Low-density lipoprotein receptor-related protein (LRP).
May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin.
 lrp-1 ELISA Kit
 lrp-1 Recombinant
 lrp-1 Antibody
 F29D11.1 ELISA Kit
 F29D11.1 Recombinant
 F29D11.1 Antibody
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Low-density lipoprotein receptor-related protein 1

 Low-density lipoprotein receptor-related protein 1 ELISA Kit
 Low-density lipoprotein receptor-related protein 1 Recombinant
 Low-density lipoprotein receptor-related protein 1 Antibody
Also known as Low-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR).
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plas
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minogen activators and their endogenous inhibitors.
 LRP1 ELISA Kit
 LRP1 Recombinant
 LRP1 Antibody
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Low-density lipoprotein receptor-related protein 10

 Low-density lipoprotein receptor-related protein 10 ELISA Kit
 Low-density lipoprotein receptor-related protein 10 Recombinant
 Low-density lipoprotein receptor-related protein 10 Antibody
Also known as Low-density lipoprotein receptor-related protein 10 (LRP-10).
LRP10: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver. Belongs to the LDLR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integ
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ral; Receptor, misc.

Cellular Component: integral to membrane; membrane

Molecular Function: low-density lipoprotein receptor activity

Biological Process: inner ear development; lipid metabolic process; lipid transport
 Lrp10 ELISA Kit
 Lrp10 Recombinant
 Lrp10 Antibody
 Lrp9 ELISA Kit
 Lrp9 Recombinant
 Lrp9 Antibody
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Low-density lipoprotein receptor-related protein 11

 Low-density lipoprotein receptor-related protein 11 ELISA Kit
 Low-density lipoprotein receptor-related protein 11 Recombinant
 Low-density lipoprotein receptor-related protein 11 Antibody
Also known as Low-density lipoprotein receptor-related protein 11 (LRP-11).
LRP11: Belongs to the LDLR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: plasma membrane

Molecular Function: phosphoprotein binding
 LRP11 ELISA Kit
 LRP11 Recombinant
 LRP11 Antibody
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Low-density lipoprotein receptor-related protein 12

 Low-density lipoprotein receptor-related protein 12 ELISA Kit
 Low-density lipoprotein receptor-related protein 12 Recombinant
 Low-density lipoprotein receptor-related protein 12 Antibody
Also known as Low-density lipoprotein receptor-related protein 12 (LRP-12).
LRP12: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. Belongs to the LDLR family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Compo
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nent: integral to plasma membrane
 Lrp12 ELISA Kit
 Lrp12 Recombinant
 Lrp12 Antibody
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Low-density lipoprotein receptor-related protein 1B

 Low-density lipoprotein receptor-related protein 1B ELISA Kit
 Low-density lipoprotein receptor-related protein 1B Recombinant
 Low-density lipoprotein receptor-related protein 1B Antibody
Also known as Low-density lipoprotein receptor-related protein 1B (LRP-1B) (Low-density lipoprotein receptor-related protein-deleted in tumor) (LRP-DIT).
LRP1B: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. Belongs to the LDLR family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: m
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embrane; receptor complex

Molecular Function: low-density lipoprotein receptor activity; protein binding

Biological Process: in utero embryonic development
 Lrp1b ELISA Kit
 Lrp1b Recombinant
 Lrp1b Antibody
 Lrpdit ELISA Kit
 Lrpdit Recombinant
 Lrpdit Antibody
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Low-density lipoprotein receptor-related protein 2

 Low-density lipoprotein receptor-related protein 2 ELISA Kit
 Low-density lipoprotein receptor-related protein 2 Recombinant
 Low-density lipoprotein receptor-related protein 2 Antibody
Also known as Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin).
LRP2: Acts together with cubilin to mediate HDL endocytosis. May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS); also known as faciooculoacousticorenal syndrome (FOAR synd
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rome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. Belongs to the LDLR family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: apical plasma membrane; lysosomal membrane; lysosome; plasma membrane; receptor complex

Molecular Function: lipoprotein transporter activity; low-density lipoprotein receptor activity; protein binding

Biological Process: endocytosis; lipid metabolic process; protein amino acid glycosylation; retinoid metabolic process; vitamin D metabolic process

Disease: Donnai-barrow Syndrome
 LRP2 ELISA Kit
 LRP2 Recombinant
 LRP2 Antibody
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Low-density lipoprotein receptor-related protein 3

 Low-density lipoprotein receptor-related protein 3 ELISA Kit
 Low-density lipoprotein receptor-related protein 3 Recombinant
 Low-density lipoprotein receptor-related protein 3 Antibody
Also known as Low-density lipoprotein receptor-related protein 3 (LRP-3) (105 kDa low-density lipoprotein receptor-related protein) (hLRp105).
LRP3: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro. Belongs to
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the LDLR family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.11

Biological Process: receptor-mediated endocytosis
 LRP3 ELISA Kit
 LRP3 Recombinant
 LRP3 Antibody
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Low-density lipoprotein receptor-related protein 4

 Low-density lipoprotein receptor-related protein 4 ELISA Kit
 Low-density lipoprotein receptor-related protein 4 Recombinant
 Low-density lipoprotein receptor-related protein 4 Antibody
Also known as Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan).
LRP4: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and
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recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Defects in LRP4 are the cause of Cenani-Lenz syndactyly syndrome (CLSS). It is a congenital malformation syndrome defined as complete and complex syndactyly of the hands combined with malformations of the forearm bones and similar manifestations in the lower limbs. Defects in LRP4 are the cause of sclerosteosis type 2 (SOST2). A sclerosing bone dysplasia characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients. Belongs to the LDLR family.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Cellular Component: cell soma; cell surface; dendrite; flotillin complex; neuromuscular junction; plasma membrane; postsynaptic density

Molecular Function: apolipoprotein binding; protein binding; protein homodimerization activity; receptor tyrosine kinase binding

Biological Process: anatomical structure development; dendrite morphogenesis; dorsal/ventral pattern formation; embryonic digit morphogenesis; embryonic limb morphogenesis; hair follicle development; kidney development; limb development; negative regulation of axonogenesis; negative regulation of ossification; negative regulation of Wnt receptor signaling pathway; odontogenesis of dentine-containing teeth; positive regulation of peptidyl-tyrosine phosphorylation; protein heterotetramerization; protein localization; proximal/distal pattern formation; receptor clustering; regulation of protein amino acid phosphorylation; synapse organization and biogenesis; synaptic growth at neuromuscular junction; Wnt receptor signaling pathway
 Lrp4 ELISA Kit
 Lrp4 Recombinant
 Lrp4 Antibody
 Kiaa0816 ELISA Kit
 Kiaa0816 Recombinant
 Kiaa0816 Antibody
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Low-density lipoprotein receptor-related protein 5

 Low-density lipoprotein receptor-related protein 5 ELISA Kit
 Low-density lipoprotein receptor-related protein 5 Recombinant
 Low-density lipoprotein receptor-related protein 5 Antibody
Also known as Low-density lipoprotein receptor-related protein 5 (LRP-5).
LRP5: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphoryl
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ation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1. Widely expressed, with the highest level of expression in the liver and in aorta. Belongs to the LDLR family.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: plasma membrane; receptor complex

Molecular Function: protein binding; toxin transporter activity; Wnt receptor activity; Wnt-protein binding

Biological Process: bone marrow development; cholesterol homeostasis; glucose catabolic process; negative regulation of osteoblast differentiation; osteoblast development; positive regulation of cell proliferation; positive regulation of fat cell differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of mitosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of blood pressure; retina morphogenesis in camera-type eye; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Disease: Bone Mineral Density Quantitative Trait Locus 1; Endosteal Hyperostosis, Autosomal Dominant; Exudative Vitreoretinopathy 1; Exudative Vitreoretinopathy 4; Osteopetrosis, Autosomal Dominant 1; Osteoporosis; Osteoporosis-pseudoglioma Syndrome; Van Buchem Disease, Type 2
 LRP5 ELISA Kit
 LRP5 Recombinant
 LRP5 Antibody
 LR3 ELISA Kit
 LR3 Recombinant
 LR3 Antibody
 LRP7 ELISA Kit
 LRP7 Recombinant
 LRP7 Antibody
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Low-density lipoprotein receptor-related protein 6

 Low-density lipoprotein receptor-related protein 6 ELISA Kit
 Low-density lipoprotein receptor-related protein 6 Recombinant
 Low-density lipoprotein receptor-related protein 6 Antibody
Also known as Low-density lipoprotein receptor-related protein 6 (LRP-6).
LRP6: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex
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recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Forms a WNT-signaling complex formed of a WNT protein, a FZD protein and LRP5 or LRP6. Interacts (via the extracellular domain) with WNT1; the interaction is enhanced by prior formation of the Wnt/Fzd complex. Interacts (via the beta-propeller regions 3 and 4) with WNT3A. Interacts (via the beta-propeller regions 1 and 2) with WNT9B. Interacts with FZD5; the interaction forms a coreceptor complex for Wnt signaling and is inhibited by DKK1 and C1orf187. Interacts (via beta propeller region) with DKK1; the interaction inhibits FZD5/LRP6 complex formation. Interacts with DKK2. Interacts with C1orf187/DRAXIN; the interaction inhibits Wnt signaling. Interacts (via the phosphorylated PPPSP motifs) with AXIN1; the interaction recruits the AXIN1/GSK3B complex to cell surface LRP6 signalsomes. Interacts with GRB10; the interaction prevents AXIN1 binding, thus negatively regulating the Wnt signaling pathway. Interacts (via the extracellular domain) with RSPO1; the interaction activates Wnt/beta-catenin signaling. Interacts (via the extracellular domain) with RSPO3 (via the cysteine rich domain); the interaction activates Wnt/beta-catenin signaling. Interacts (via the beta- propeller regions 1 and 2) with SOST; the interaction competes with DKK1 for binding for inhibiting beta-catenin signaling. Interacts with MESD; the interaction prevents the formation of LRP6 aggregates and targets LRP6 to the plasma membrane. Interacts (via the cytoplasmic domain) with CSNKIE; the interaction phosphorylates LRP6, binds AXIN1 and inhibits AXIN1/GSK3B-mediated phosphorylation of beta-catenin. Interacts with MACF1. Decreased levels on WNT3A stimulation. Widely co-expressed with LRP5 during embryogenesis and in adult tissues. Belongs to the LDLR family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: caveola; cell soma; cell surface; cytoplasmic vesicle; early endosome; Golgi apparatus; membrane; plasma membrane; receptor complex; synapse

Molecular Function: apolipoprotein binding; frizzled binding; kinase inhibitor activity; low-density lipoprotein receptor activity; protein binding; protein homodimerization activity; receptor binding; toxin transporter activity; Wnt receptor activity; Wnt-protein binding

Biological Process: anterior/posterior pattern formation; bone remodeling; cell migration involved in gastrulation; cell-cell adhesion; cerebellum morphogenesis; cerebral cortex cell migration; cerebral cortex development; convergent extension; dorsal/ventral axis specification; elevation of cytosolic calcium ion concentration; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; embryonic limb morphogenesis; embryonic pattern specification; embryonic retina morphogenesis in camera-type eye; external genitalia morphogenesis; forebrain development; formation of radial glial scaffolds; gastrulation with mouth forming second; generation of neurons; generation of neurons in the forebrain; heart looping; limb morphogenesis; midbrain development; midbrain-hindbrain boundary development; morphogenesis of an epithelium; negative regulation of epithelial cell proliferation; negative regulation of fat cell differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of protein kinase activity; negative regulation of Wnt receptor signaling pathway; neural crest cell differentiation; neural crest formation; neural tube closure; neural tube development; odontogenesis of dentine-containing teeth; palate development; positive regulation of apoptosis; positive regulation of bone resorption; positive regulation of cell cycle; positive regulation of mesenchymal cell proliferation; positive regulation of ossification; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; radial glial cell differentiation in the forebrain; regulation of cell proliferation; regulation of transcription, DNA-dependent; response to folic acid; retina morphogenesis in camera-type eye; skeletal morphogenesis; somitogenesis; synaptic transmission; thalamus development; Wnt receptor signaling pathway; Wnt receptor signaling pathway in forebrain neuroblast division; Wnt receptor signaling pathway through beta-catenin
 Lrp6 ELISA Kit
 Lrp6 Recombinant
 Lrp6 Antibody
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Low-density lipoprotein receptor-related protein 8

 Low-density lipoprotein receptor-related protein 8 ELISA Kit
 Low-density lipoprotein receptor-related protein 8 Recombinant
 Low-density lipoprotein receptor-related protein 8 Antibody
Also known as Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2).
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays
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a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
 LRP8 ELISA Kit
 LRP8 Recombinant
 LRP8 Antibody
 APOER2 ELISA Kit
 APOER2 Recombinant
 APOER2 Antibody
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