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Lymphoid enhancer-binding factor

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1.

Below are the list of possible Lymphoid enhancer-binding factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Lymphoid enhancer-binding factor 1

 Lymphoid enhancer-binding factor 1 ELISA Kit
 Lymphoid enhancer-binding factor 1 Recombinant
 Lymphoid enhancer-binding factor 1 Antibody
Also known as Lymphoid enhancer-binding factor 1 (LEF-1).
LEF-1: a transcription factor of the TCF/LEF family. Participates in the Wnt signaling pathway and regulates T-cell receptor alpha-C enhancer function. Activates transcription of target genes in the presence of CTNNB1 and EP300. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Binds DNA in a sequence-specif
ic manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. Deletions in LEF1 have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Four human isoforms produced by alternative promoter usage and alternative splicing have been described. Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling.

Protein type: DNA-binding; Transcription factor

Cellular Component: cytoplasm; nucleus; transcription factor complex

Molecular Function: beta-catenin binding; caspase inhibitor activity; chromatin binding; DNA bending activity; DNA binding; estrogen receptor activity; estrogen receptor binding; gamma-catenin binding; histone binding; histone deacetylase binding; protein binding; RNA polymerase II transcription factor activity, enhancer binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding

Biological Process: alpha-beta T cell differentiation; anatomical structure regression; B cell proliferation; BMP signaling pathway; cell development; dentate gyrus development; embryonic limb morphogenesis; epithelial to mesenchymal transition; eye pigmentation; forebrain neuroblast division; forebrain neuron differentiation; formation of radial glial scaffolds; hippocampus development; hypothalamus development; mammary gland development; muscle fiber development; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of DNA binding; negative regulation of interleukin-13 production; negative regulation of interleukin-4 production; negative regulation of interleukin-5 production; negative regulation of striated muscle development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural crest cell migration; neutrophil differentiation; odontogenesis of dentine-containing teeth; osteoblast differentiation; palate development; paraxial mesoderm formation; patterning of blood vessels; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of granulocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; radial glial cell differentiation in the forebrain; regulation of cell-cell adhesion; regulation of transcription from RNA polymerase II promoter; regulation of Wnt receptor signaling pathway; sensory perception of taste; somitogenesis; sprouting angiogenesis; T cell receptor V(D)J recombination; T-helper 1 cell differentiation; tongue development; transcription from RNA polymerase II promoter; vasculature development; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin
 Lef1 ELISA Kit
 Lef1 Recombinant
 Lef1 Antibody
 Lef-1 ELISA Kit
 Lef-1 Recombinant
 Lef-1 Antibody
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