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Lysine-specific demethylase

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Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.

Below are the list of possible Lysine-specific demethylase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Lysine-specific demethylase 2A

 Lysine-specific demethylase 2A ELISA Kit
 Lysine-specific demethylase 2A Recombinant
 Lysine-specific demethylase 2A Antibody
Also known as Lysine-specific demethylase 2A (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A).
FBXL11: Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys- 36'. May also recognize and bind to some phosphorylated proteins and promote t
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heir ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Belongs to the JHDM1 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.27; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function: histone demethylase activity; protein binding

Biological Process: double-strand break repair via nonhomologous end joining
 KDM2A ELISA Kit
 KDM2A Recombinant
 KDM2A Antibody
 CXXC8 ELISA Kit
 CXXC8 Recombinant
 CXXC8 Antibody
 FBL7 ELISA Kit
 FBL7 Recombinant
 FBL7 Antibody
 FBXL11 ELISA Kit
 FBXL11 Recombinant
 FBXL11 Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 2B

 Lysine-specific demethylase 2B ELISA Kit
 Lysine-specific demethylase 2B Recombinant
 Lysine-specific demethylase 2B Antibody
Also known as Lysine-specific demethylase 2B (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-conta.
FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of
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ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Demethylase; EC 1.14.11.27; Nucleolus; Oxidoreductase

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: nucleoplasm; PcG protein complex

Molecular Function: histone demethylase activity; protein binding

Biological Process: embryonic camera-type eye morphogenesis; forebrain development; fourth ventricle development; hindbrain development; initiation of neural tube closure; lateral ventricle development; midbrain development; midbrain-hindbrain boundary morphogenesis; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; spermatogenesis; third ventricle development
 KDM2B ELISA Kit
 KDM2B Recombinant
 KDM2B Antibody
 CXXC2 ELISA Kit
 CXXC2 Recombinant
 CXXC2 Antibody
 FBL10 ELISA Kit
 FBL10 Recombinant
 FBL10 Antibody
 FBXL10 ELISA Kit
 FBXL10 Recombinant
 FBXL10 Antibody
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Lysine-specific demethylase 3A

 Lysine-specific demethylase 3A ELISA Kit
 Lysine-specific demethylase 3A Recombinant
 Lysine-specific demethylase 3A Antibody
Also known as Lysine-specific demethylase 3A (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A).
JMJD1A: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in r
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ecruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. Belongs to the JHDM2 histone demethylase family.

Protein type: Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase

Cellular Component: chromatin; cytoplasm; membrane; nucleoplasm; nucleus

Molecular Function: androgen receptor binding; chromatin DNA binding; histone demethylase activity (H3-K9 specific); iron ion binding; protein binding; transcription factor activity

Biological Process: androgen receptor signaling pathway; formaldehyde biosynthetic process; histone H3-K9 demethylation; hormone-mediated signaling; negative regulation of histone H3-K9 methylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression; spermatid nuclear elongation; spermatogenesis
 Kdm3a ELISA Kit
 Kdm3a Recombinant
 Kdm3a Antibody
 Jhdm2a ELISA Kit
 Jhdm2a Recombinant
 Jhdm2a Antibody
 Jmjd1a ELISA Kit
 Jmjd1a Recombinant
 Jmjd1a Antibody
 Kiaa0742 ELISA Kit
 Kiaa0742 Recombinant
 Kiaa0742 Antibody
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Lysine-specific demethylase 3A-A

 Lysine-specific demethylase 3A-A ELISA Kit
 Lysine-specific demethylase 3A-A Recombinant
 Lysine-specific demethylase 3A-A Antibody
Also known as Lysine-specific demethylase 3A-A (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A-A).
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate ().
 kdm3a-a ELISA Kit
 kdm3a-a Recombinant
 kdm3a-a Antibody
 jhdm2a-a ELISA Kit
 jhdm2a-a Recombinant
 jhdm2a-a Antibody
 jmjd1a-a ELISA Kit
 jmjd1a-a Recombinant
 jmjd1a-a Antibody
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Lysine-specific demethylase 3A-B

 Lysine-specific demethylase 3A-B ELISA Kit
 Lysine-specific demethylase 3A-B Recombinant
 Lysine-specific demethylase 3A-B Antibody
Also known as Lysine-specific demethylase 3A-B (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A-B).
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate ().
 kdm3a-b ELISA Kit
 kdm3a-b Recombinant
 kdm3a-b Antibody
 jhdm2a-b ELISA Kit
 jhdm2a-b Recombinant
 jhdm2a-b Antibody
 jmjd1a-b ELISA Kit
 jmjd1a-b Recombinant
 jmjd1a-b Antibody
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Lysine-specific demethylase 3B

 Lysine-specific demethylase 3B ELISA Kit
 Lysine-specific demethylase 3B Recombinant
 Lysine-specific demethylase 3B Antibody
Also known as Lysine-specific demethylase 3B (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B).
JMJD1B: a ubiquitous protein demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity. Three alternatively spliced isoforms have been reported.

Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase

Cellular Component: chromatin; nucleus

Molecular Function: antioxidant activ
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ity; chromatin DNA binding; histone demethylase activity (H3-K9 specific)

Biological Process: histone H3-K9 demethylation; regulation of transcription, DNA-dependent
 Kdm3b ELISA Kit
 Kdm3b Recombinant
 Kdm3b Antibody
 Jhdm2b ELISA Kit
 Jhdm2b Recombinant
 Jhdm2b Antibody
 Jmjd1b ELISA Kit
 Jmjd1b Recombinant
 Jmjd1b Antibody
 Kiaa1082 ELISA Kit
 Kiaa1082 Recombinant
 Kiaa1082 Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 4

 Lysine-specific demethylase 4 ELISA Kit
 Lysine-specific demethylase 4 Recombinant
 Lysine-specific demethylase 4 Antibody
Also known as Lysine-specific demethylase 4 (JmjC domain-containing histone demethylation protein 2) (ceJMJD2).
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
 jmjd-2 ELISA Kit
 jmjd-2 Recombinant
 jmjd-2 Antibody
 Y48B6A.11 ELISA Kit
 Y48B6A.11 Recombinant
 Y48B6A.11 Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 4A

 Lysine-specific demethylase 4A ELISA Kit
 Lysine-specific demethylase 4A Recombinant
 Lysine-specific demethylase 4A Antibody
Also known as Lysine-specific demethylase 4A (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A).
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASC
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L2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively ().
 KDM4A ELISA Kit
 KDM4A Recombinant
 KDM4A Antibody
 JHDM3A ELISA Kit
 JHDM3A Recombinant
 JHDM3A Antibody
 JMJD2A ELISA Kit
 JMJD2A Recombinant
 JMJD2A Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 4B

 Lysine-specific demethylase 4B ELISA Kit
 Lysine-specific demethylase 4B Recombinant
 Lysine-specific demethylase 4B Antibody
Also known as Lysine-specific demethylase 4B (JmjC domain-containing histone demethylation protein 3B) (Jumonji domain-containing protein 2B).
JMJD2B: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 isoforms of the human prote
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in are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: histone demethylase activity
 KDM4B ELISA Kit
 KDM4B Recombinant
 KDM4B Antibody
 JHDM3B ELISA Kit
 JHDM3B Recombinant
 JHDM3B Antibody
 JMJD2B ELISA Kit
 JMJD2B Recombinant
 JMJD2B Antibody
 KIAA0876 ELISA Kit
 KIAA0876 Recombinant
 KIAA0876 Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 4C

 Lysine-specific demethylase 4C ELISA Kit
 Lysine-specific demethylase 4C Recombinant
 Lysine-specific demethylase 4C Antibody
Also known as Lysine-specific demethylase 4C (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C).
JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histon
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e H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: nuclear chromatin; nucleoplasm

Molecular Function: androgen receptor binding; enzyme binding; histone demethylase activity; histone demethylase activity (H3-K9 specific)

Biological Process: histone H3-K9 demethylation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter
 KDM4C ELISA Kit
 KDM4C Recombinant
 KDM4C Antibody
 GASC1 ELISA Kit
 GASC1 Recombinant
 GASC1 Antibody
 JHDM3C ELISA Kit
 JHDM3C Recombinant
 JHDM3C Antibody
 JMJD2C ELISA Kit
 JMJD2C Recombinant
 JMJD2C Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 4D

 Lysine-specific demethylase 4D ELISA Kit
 Lysine-specific demethylase 4D Recombinant
 Lysine-specific demethylase 4D Antibody
Also known as Lysine-specific demethylase 4D (JmjC domain-containing histone demethylation protein 3D) (Jumonji domain-containing protein 2D).
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate ().
 Kdm4d ELISA Kit
 Kdm4d Recombinant
 Kdm4d Antibody
 Jhdm3d ELISA Kit
 Jhdm3d Recombinant
 Jhdm3d Antibody
 Jmjd2d ELISA Kit
 Jmjd2d Recombinant
 Jmjd2d Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 4E

 Lysine-specific demethylase 4E ELISA Kit
 Lysine-specific demethylase 4E Recombinant
 Lysine-specific demethylase 4E Antibody
Also known as Lysine-specific demethylase 4E (KDM4D-like protein) (Lysine-specific demethylase 4D-like).
KDM4DL: Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Belongs to the JHDM3 histone demethylase family.

Protein type: EC 1.14.11.-

Chromosomal Location of Human Ortholog: 11q21
 KDM4E ELISA Kit
 KDM4E Recombinant
 KDM4E Antibody
 KDM4DL ELISA Kit
 KDM4DL Recombinant
 KDM4DL Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 5A

 Lysine-specific demethylase 5A ELISA Kit
 Lysine-specific demethylase 5A Recombinant
 Lysine-specific demethylase 5A Antibody
Also known as Lysine-specific demethylase 5A (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2).
JARID1A: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during
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cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Interacts with SUZ12; the interaction is direct. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: cyclin-dependent protein kinase activating kinase holoenzyme complex; cytoplasm; nucleoplasm; nucleus

Molecular Function: DNA binding; histone demethylase activity; protein binding; transcription coactivator activity; transcription factor activity

Biological Process: circadian regulation of gene expression; positive regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter
 KDM5A ELISA Kit
 KDM5A Recombinant
 KDM5A Antibody
 JARID1A ELISA Kit
 JARID1A Recombinant
 JARID1A Antibody
 RBBP2 ELISA Kit
 RBBP2 Recombinant
 RBBP2 Antibody
 RBP2 ELISA Kit
 RBP2 Recombinant
 RBP2 Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 5B

 Lysine-specific demethylase 5B ELISA Kit
 Lysine-specific demethylase 5B Recombinant
 Lysine-specific demethylase 5B Antibody
Also known as Lysine-specific demethylase 5B (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1).
JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppres
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sor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: histone demethylase activity; histone demethylase activity (H3-K4 specific); protein binding; transcription corepressor activity; transcription factor activity
 KDM5B ELISA Kit
 KDM5B Recombinant
 KDM5B Antibody
 JARID1B ELISA Kit
 JARID1B Recombinant
 JARID1B Antibody
 PLU1 ELISA Kit
 PLU1 Recombinant
 PLU1 Antibody
 RBBP2H1 ELISA Kit
 RBBP2H1 Recombinant
 RBBP2H1 Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 5B-B

 Lysine-specific demethylase 5B-B ELISA Kit
 Lysine-specific demethylase 5B-B Recombinant
 Lysine-specific demethylase 5B-B Antibody
Also known as Lysine-specific demethylase 5B-B (Histone demethylase JARID1B-B) (Jumonji/ARID domain-containing protein 1B-B).
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor ().
 kdm5bb ELISA Kit
 kdm5bb Recombinant
 kdm5bb Antibody
 jarid1b ELISA Kit
 jarid1b Recombinant
 jarid1b Antibody
 jarid1bb ELISA Kit
 jarid1bb Recombinant
 jarid1bb Antibody
 si:dkey-193l3.2 ELISA Kit
 si:dkey-193l3.2 Recombinant
 si:dkey-193l3.2 Antibody
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Lysine-specific demethylase 5C

 Lysine-specific demethylase 5C ELISA Kit
 Lysine-specific demethylase 5C Recombinant
 Lysine-specific demethylase 5C Antibody
Also known as Lysine-specific demethylase 5C (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX).
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements ().
 KDM5C ELISA Kit
 KDM5C Recombinant
 KDM5C Antibody
 JARID1C ELISA Kit
 JARID1C Recombinant
 JARID1C Antibody
 SMCX ELISA Kit
 SMCX Recombinant
 SMCX Antibody
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Lysine-specific demethylase 5D

 Lysine-specific demethylase 5D ELISA Kit
 Lysine-specific demethylase 5D Recombinant
 Lysine-specific demethylase 5D Antibody
Also known as Lysine-specific demethylase 5D (Histocompatibility Y antigen) (H-Y) (Histone demethylase JARID1D) (Jumonji/ARID domain-containing protein 1D) (Protein SmcY).
JARID1D: Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Belongs to the JARID1 histone demethylase family. 3 isoforms of the human protein a
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re produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase

Molecular Function: histone demethylase activity (H3-K4 specific)

Biological Process: T cell antigen processing and presentation
 Kdm5d ELISA Kit
 Kdm5d Recombinant
 Kdm5d Antibody
 Hya ELISA Kit
 Hya Recombinant
 Hya Antibody
 Jarid1d ELISA Kit
 Jarid1d Recombinant
 Jarid1d Antibody
 Smcy ELISA Kit
 Smcy Recombinant
 Smcy Antibody
Table BarTOPTable Bar
 

Lysine-specific demethylase 6A

 Lysine-specific demethylase 6A ELISA Kit
 Lysine-specific demethylase 6A Recombinant
 Lysine-specific demethylase 6A Antibody
Also known as Lysine-specific demethylase 6A (Histone demethylase UTX) (Ubiquitously transcribed TPR protein on the X chromosome) (Ubiquitously transcribed X chromosome tetratricopeptide repeat protein).
UTX: a nuclear protein that contains 8 tetratrico peptide repeat (TPRs). Processes involving TPR proteins include cell-cycle control, transcription repression, stress response, protein
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kinase inhibition, mitochondrial and peroxisomal protein transport and neurogenesis.

Protein type: EC 1.14.11.-; Oxidoreductase

Cellular Component: histone methyltransferase complex; nucleus

Molecular Function: chromatin binding; chromatin DNA binding; identical protein binding; protein binding

Biological Process: embryonic organ development; heart development; heart morphogenesis; in utero embryonic development; mesodermal cell differentiation; multicellular organism growth; neural tube closure; neural tube development; notochord morphogenesis; regulation of gene expression; respiratory system process; somite rostral/caudal axis specification; Wnt receptor signaling pathway through beta-catenin
 Kdm6a ELISA Kit
 Kdm6a Recombinant
 Kdm6a Antibody
 Utx ELISA Kit
 Utx Recombinant
 Utx Antibody
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Lysine-specific demethylase 6B

 Lysine-specific demethylase 6B ELISA Kit
 Lysine-specific demethylase 6B Recombinant
 Lysine-specific demethylase 6B Antibody
Also known as Lysine-specific demethylase 6B (JmjC domain-containing protein 3) (Jumonji domain-containing protein 3).
JMJD3: Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Compon
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ent of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Oxidoreductase

Cellular Component: nucleus

Molecular Function: beta-catenin binding; chromatin binding; sequence-specific DNA binding

Biological Process: cardiac muscle cell differentiation; cell fate commitment; endothelial cell differentiation; hippocampus development; histone demethylation; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression
 Kdm6b ELISA Kit
 Kdm6b Recombinant
 Kdm6b Antibody
 Jmjd3 ELISA Kit
 Jmjd3 Recombinant
 Jmjd3 Antibody
 Kiaa0346 ELISA Kit
 Kiaa0346 Recombinant
 Kiaa0346 Antibody
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Lysine-specific demethylase 7 homolog

 Lysine-specific demethylase 7 homolog ELISA Kit
 Lysine-specific demethylase 7 homolog Recombinant
 Lysine-specific demethylase 7 homolog Antibody
Also known as Lysine-specific demethylase 7 homolog (ceKDM7A) (JmjC domain-containing protein 1.2) (PHD finger protein 8 homolog) (PHF8 homolog).
Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code.
 jmjd-1.2 ELISA Kit
 jmjd-1.2 Recombinant
 jmjd-1.2 Antibody
 F29B9.2 ELISA Kit
 F29B9.2 Recombinant
 F29B9.2 Antibody
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Lysine-specific demethylase 7A

 Lysine-specific demethylase 7A ELISA Kit
 Lysine-specific demethylase 7A Recombinant
 Lysine-specific demethylase 7A Antibody
Also known as Lysine-specific demethylase 7A (DrKDM7a) (JmjC domain-containing histone demethylation protein 1D-A).
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code ().
 kdm7a ELISA Kit
 kdm7a Recombinant
 kdm7a Antibody
 jhdm1da ELISA Kit
 jhdm1da Recombinant
 jhdm1da Antibody
 kdm7 ELISA Kit
 kdm7 Recombinant
 kdm7 Antibody
 si:dkey-105o6.2 ELISA Kit
 si:dkey-105o6.2 Recombinant
 si:dkey-105o6.2 Antibody
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Lysine-specific demethylase 7B

 Lysine-specific demethylase 7B ELISA Kit
 Lysine-specific demethylase 7B Recombinant
 Lysine-specific demethylase 7B Antibody
Also known as Lysine-specific demethylase 7B (DrKDM7b) (JmjC domain-containing histone demethylation protein 1D-B).
Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code ().
 jhdm1db ELISA Kit
 jhdm1db Recombinant
 jhdm1db Antibody
 kdm7b ELISA Kit
 kdm7b Recombinant
 kdm7b Antibody
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Lysine-specific demethylase 8

 Lysine-specific demethylase 8 ELISA Kit
 Lysine-specific demethylase 8 Recombinant
 Lysine-specific demethylase 8 Antibody
Also known as Lysine-specific demethylase 8 (JmjC domain-containing protein 5) (Jumonji domain-containing protein 5).
Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator ().
 kdm8 ELISA Kit
 kdm8 Recombinant
 kdm8 Antibody
 jmjd5 ELISA Kit
 jmjd5 Recombinant
 jmjd5 Antibody
 zgc:173863 ELISA Kit
 zgc:173863 Recombinant
 zgc:173863 Antibody
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Lysine-specific demethylase hairless

 Lysine-specific demethylase hairless ELISA Kit
 Lysine-specific demethylase hairless Recombinant
 Lysine-specific demethylase hairless Antibody
HR: May act as a transcription factor that could act on to regulate one of the phases of hair growth. Defects in HR are the cause of alopecia universalis congenita (ALUNC). ALUNC is a rare autosomal r
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ecessive form of hair loss characterized by hair follicles without hair. Defects in HR are the cause of atrichia with papular lesions (APL); also known as congenital atrichia. APL is an autosomal recessive disease characterized by papillary lesions over most of the body and almost complete absence of hair. Defects in HR are the cause of hypotrichosis type 4 (HYPT4). An autosomal dominant condition characterized by reduced amount of hair, alopecia, little or no eyebrows, eyelashes or body hair, and coarse, wiry, twisted hair in early childhood. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: chromatin; histone deacetylase complex; nuclear body; nucleoplasm

Molecular Function: chromatin DNA binding; histone deacetylase binding; histone demethylase activity (H3-K9 specific); thyroid hormone receptor binding; transcription corepressor activity; vitamin D receptor binding

Biological Process: histone H3-K9 demethylation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; protein heterooligomerization
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Lysine-specific demethylase JMJ15

 Lysine-specific demethylase JMJ15 ELISA Kit
 Lysine-specific demethylase JMJ15 Recombinant
 Lysine-specific demethylase JMJ15 Antibody
Also known as Lysine-specific demethylase JMJ15 (Jumonji domain-containing protein 15) (Lysine-specific histone demethylase JMJ15) (Protein JUMONJI 15) (Protein MATERNAL EFFECT EMBRYO ARREST 27).
A maternally expressed imprinted gene.
 JMJ15 ELISA Kit
 JMJ15 Recombinant
 JMJ15 Antibody
 MEE27 ELISA Kit
 MEE27 Recombinant
 MEE27 Antibody
 PKDM7C ELISA Kit
 PKDM7C Recombinant
 PKDM7C Antibody
 At2g34880 ELISA Kit
 At2g34880 Recombinant
 At2g34880 Antibody
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Lysine-specific demethylase JMJ18

 Lysine-specific demethylase JMJ18 ELISA Kit
 Lysine-specific demethylase JMJ18 Recombinant
 Lysine-specific demethylase JMJ18 Antibody
Also known as Lysine-specific demethylase JMJ18 (Jumonji domain-containing protein 18) (Lysine-specific histone demethylase JMJ18) (Protein JUMONJI 18).
JMJ18 encodes a novel JmjC domain- containing histone H3K4 demethylase.
 JMJ18 ELISA Kit
 JMJ18 Recombinant
 JMJ18 Antibody
 At1g30810 ELISA Kit
 At1g30810 Recombinant
 At1g30810 Antibody
 T17H7.10 ELISA Kit
 T17H7.10 Recombinant
 T17H7.10 Antibody
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Lysine-specific demethylase JMJ25

 Lysine-specific demethylase JMJ25 ELISA Kit
 Lysine-specific demethylase JMJ25 Recombinant
 Lysine-specific demethylase JMJ25 Antibody
Also known as Lysine-specific demethylase JMJ25 (Jumonji domain-containing protein 25) (Lysine-specific histone demethylase JMJ25) (Protein INCREASE IN BONSAI METHYLATION 1) (Protein JUMONJI 25).
IBM1 likely encodes a protein with histone H3mK9 demethylation activity. It may preferentially demethylate H3mK9 at low-copy loci to protect them from silencing by nearby heterochromatin by preventing the spread of cytosine methylation. BONSAI (At1g73177) is hypermethylated in ibm1 mutants. ibm1 mutants have morphological defects that become apparent at the F3 generation, including small narrow lea
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ves, arrested flower development, and faulty pollen development. These phenotypes cannot result solely from the BONSAI hypermethylation. Aberrant phenotypes in ibm1 mutants in both DNA methylation and plant development can be suppressed by mutations in the KYP H3K9 methyltransferase or he CMT3 non CG-cytosine methylase.
 JMJ25 ELISA Kit
 JMJ25 Recombinant
 JMJ25 Antibody
 IBM1 ELISA Kit
 IBM1 Recombinant
 IBM1 Antibody
 At3g07610 ELISA Kit
 At3g07610 Recombinant
 At3g07610 Antibody
 MLP3.6 ELISA Kit
 MLP3.6 Recombinant
 MLP3.6 Antibody
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Lysine-specific demethylase JMJ30

 Lysine-specific demethylase JMJ30 ELISA Kit
 Lysine-specific demethylase JMJ30 Recombinant
 Lysine-specific demethylase JMJ30 Antibody
Also known as Lysine-specific demethylase JMJ30 (AtJMJ30) (JmjC domain-containing protein 30) (Jumonji domain-containing protein 5) (AtJMJD5).
JMJD5 encodes a protein which contains a jumonji-C (jmjC) domain. The jumonji-C is frequently found in proteins with histone demethylase activity. jmjd5 mutant plants have a short-period circadian phenotype.
 JMJ30 ELISA Kit
 JMJ30 Recombinant
 JMJ30 Antibody
 JMJD5 ELISA Kit
 JMJD5 Recombinant
 JMJD5 Antibody
 At3g20810 ELISA Kit
 At3g20810 Recombinant
 At3g20810 Antibody
 MOE17.12 ELISA Kit
 MOE17.12 Recombinant
 MOE17.12 Antibody
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Lysine-specific demethylase JMJ703

 Lysine-specific demethylase JMJ703 ELISA Kit
 Lysine-specific demethylase JMJ703 Recombinant
 Lysine-specific demethylase JMJ703 Antibody
Also known as Lysine-specific demethylase JMJ703 (Jumonji domain-containing protein 703) (Lysine-specific histone demethylase JMJ703) (Protein JUMONJI 703).
Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a specific activity for H3K4me3, H3K4me2 and H3K4me1. No activity on H3K9me3/2/1, H3K27me3/2/1 and H3K36me3/2/1. Involved in the control of stem elongation by regulating methylation states of H3K4me3 on cytokinin oxidase (CKX) gene family, which may cause increased expression of CKX genes and reduced cytokinin levels. Prevents ectopic retrotransposition by regulat
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ing the levels of H3K4me3 in two non-LTR retrotransposons KARMA and LINE-1 (L1) and reinforcing their repressed states.
 JMJ703 ELISA Kit
 JMJ703 Recombinant
 JMJ703 Antibody
 Os05g0196500 ELISA Kit
 Os05g0196500 Recombinant
 Os05g0196500 Antibody
 LOC_Os05g10770 ELISA Kit
 LOC_Os05g10770 Recombinant
 LOC_Os05g10770 Antibody
 P0617H07.8 ELISA Kit
 P0617H07.8 Recombinant
 P0617H07.8 Antibody
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Lysine-specific demethylase JMJ705

 Lysine-specific demethylase JMJ705 ELISA Kit
 Lysine-specific demethylase JMJ705 Recombinant
 Lysine-specific demethylase JMJ705 Antibody
Also known as Lysine-specific demethylase JMJ705 (Jumonji domain-containing protein 705) (Lysine-specific histone demethylase JMJ705) (Protein JUMONJI 705).
Histone demethylase that demethylates 'Lys-27' (H3K27me) of histone H3 with a specific activity for H3K27me3 and H3K27me2. No activity on H3K4me3, H3K9me3, H3K27me1 and H3K36me3. Involved in biotic stress response. May demethylate H3K27me3-marked defense-related genes and increase their basal and induced expression levels during pathogen infection.
 JMJ705 ELISA Kit
 JMJ705 Recombinant
 JMJ705 Antibody
 Os01g0907400 ELISA Kit
 Os01g0907400 Recombinant
 Os01g0907400 Antibody
 LOC_Os01g67970 ELISA Kit
 LOC_Os01g67970 Recombinant
 LOC_Os01g67970 Antibody
 B1417F08.20 ELISA Kit
 B1417F08.20 Recombinant
 B1417F08.20 Antibody
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Lysine-specific demethylase JMJ706

 Lysine-specific demethylase JMJ706 ELISA Kit
 Lysine-specific demethylase JMJ706 Recombinant
 Lysine-specific demethylase JMJ706 Antibody
Also known as Lysine-specific demethylase JMJ706 (Jumonji domain-containing protein 706) (Lysine-specific histone demethylase JMJ706) (Protein JUMONJI 706).
Histone demethylase that demethylates 'Lys-9' (H3K9me) of histone H3 with a specific activity for H3K9me3 and H3K9me2. No activity on H3K4me3, H3K9me1, H3K27me2 and H3K36me3/2. Involved in the control of floral organ development by demethylating H3K9me3 and H3K9me2 in the promoter regions of DH1 and MADS47. The 'Lys-9' demethylation of these two genes is required for induction of their expression.
 JMJ706 ELISA Kit
 JMJ706 Recombinant
 JMJ706 Antibody
 Os10g0577600 ELISA Kit
 Os10g0577600 Recombinant
 Os10g0577600 Antibody
 LOC_Os10g42690 ELISA Kit
 LOC_Os10g42690 Recombinant
 LOC_Os10g42690 Antibody
 OSJNBa0035H01.2 ELISA Kit
 OSJNBa0035H01.2 Recombinant
 OSJNBa0035H01.2 Antibody
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Lysine-specific demethylase lid

 Lysine-specific demethylase lid ELISA Kit
 Lysine-specific demethylase lid Recombinant
 Lysine-specific demethylase lid Antibody
Also known as Lysine-specific demethylase lid (Histone demethylase lid) (Jumonji/ARID domain-containing protein lid) (Protein little imaginal disks) (Retinoblastoma-binding protein 2 homolog).
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or
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H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.
 lid ELISA Kit
 lid Recombinant
 lid Antibody
 CG9088 ELISA Kit
 CG9088 Recombinant
 CG9088 Antibody
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Lysine-specific demethylase PHF2

 Lysine-specific demethylase PHF2 ELISA Kit
 Lysine-specific demethylase PHF2 Recombinant
 Lysine-specific demethylase PHF2 Antibody
Also known as Lysine-specific demethylase PHF2 (GRC5) (PHD finger protein 2).
PHF2: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to targe
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t promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Component of the PHF2-ARID5B complex, at least composed of PHF2 and ARID5B. Interacts with HNF4A and NR1H4. Widely expressed, including in liver. Enzymatically inactive by itself, and become active following phosphorylation by PKA. Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

Protein type: EC 1.14.11.-; Nucleolus

Cellular Component: cytoplasm; kinetochore; nucleolus; nucleus

Molecular Function: histone demethylase activity (H3-K9 specific); iron ion binding; methylated histone residue binding; transcription coactivator activity; zinc ion binding

Biological Process: histone H3-K9 demethylation; protein amino acid demethylation
 Phf2 ELISA Kit
 Phf2 Recombinant
 Phf2 Antibody
 Kiaa0662 ELISA Kit
 Kiaa0662 Recombinant
 Kiaa0662 Antibody
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Lysine-specific demethylase rbr-2

 Lysine-specific demethylase rbr-2 ELISA Kit
 Lysine-specific demethylase rbr-2 Recombinant
 Lysine-specific demethylase rbr-2 Antibody
Also known as Lysine-specific demethylase rbr-2 (Histone demethylase rbr-2) (Jumonji/ARID domain-containing protein rbr-2).
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not mono
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methylated H3 'Lys-4'. Involved in larval development and vulva formation.
 rbr-2 ELISA Kit
 rbr-2 Recombinant
 rbr-2 Antibody
 ZK593.4 ELISA Kit
 ZK593.4 Recombinant
 ZK593.4 Antibody
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Lysine-specific demethylase REF6

 Lysine-specific demethylase REF6 ELISA Kit
 Lysine-specific demethylase REF6 Recombinant
 Lysine-specific demethylase REF6 Antibody
Also known as Lysine-specific demethylase REF6 (Jumonji domain-containing protein 12) (Lysine-specific histone demethylase REF6) (Protein RELATIVE OF EARLY FLOWERING 6).
Relative of Early Flowering 6 (REF6) encodes a Jumonji N/C and zinc finger domain-containing protein that acts as a positive regulator of flowering in an FLC-dependent pathway. REF6 mutants have hyperacetylation of histone H4 at the FLC locus. REF6 interacts with BES1 in a Y2H assay and in vitro. REF6 may play a role in brassinoteroid signaling by affecting histone methylation in the promoters of BR-responsive genes. It is
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most closely related to the JHDM3 subfamily of JmjN/C proteins.
 REF6 ELISA Kit
 REF6 Recombinant
 REF6 Antibody
 JMJ12 ELISA Kit
 JMJ12 Recombinant
 JMJ12 Antibody
 PKDM9A ELISA Kit
 PKDM9A Recombinant
 PKDM9A Antibody
 At3g48430 ELISA Kit
 At3g48430 Recombinant
 At3g48430 Antibody
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Lysine-specific demethylase SE14

 Lysine-specific demethylase SE14 ELISA Kit
 Lysine-specific demethylase SE14 Recombinant
 Lysine-specific demethylase SE14 Antibody
Also known as Lysine-specific demethylase SE14 (Protein PHOTOPERIOD SENSITIVITY 14).
Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3. Involved in the control of flowering time. Has a suppressive effect on floral transition under long day conditions through the demethylation of H3K4me3 in the promoter region of the flower-promoting signal HD3B/RFT1.
 SE14 ELISA Kit
 SE14 Recombinant
 SE14 Antibody
 Os03g0151300 ELISA Kit
 Os03g0151300 Recombinant
 Os03g0151300 Antibody
 LOC_Os03g05690 ELISA Kit
 LOC_Os03g05690 Recombinant
 LOC_Os03g05690 Antibody
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Proteins Root Name Listing
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