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Lysophosphatidic acid receptor

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Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain.

Below are the list of possible Lysophosphatidic acid receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Lysophosphatidic acid receptor 1

 Lysophosphatidic acid receptor 1 ELISA Kit
 Lysophosphatidic acid receptor 1 Recombinant
 Lysophosphatidic acid receptor 1 Antibody
Also known as Lysophosphatidic acid receptor 1 (LPA receptor 1) (LPA-1) (Lysophosphatidic acid receptor Edg-2).
LPAR1: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: cell soma; cell
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surface; cytoplasm; dendritic shaft; dendritic spine; endocytic vesicle; endosome; integral to plasma membrane; neuron projection; plasma membrane

Molecular Function: G-protein alpha-subunit binding; G-protein coupled receptor activity; PDZ domain binding; phospholipid binding

Biological Process: activation of MAPK activity; bleb formation; brain development; cerebellum development; corpus callosum development; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; myelination; negative regulation of cAMP biosynthetic process; neurogenesis; oligodendrocyte development; optic nerve development; phospholipase C activation; positive regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; regulation of cell shape
 Lpar1 ELISA Kit
 Lpar1 Recombinant
 Lpar1 Antibody
 Edg2 ELISA Kit
 Edg2 Recombinant
 Edg2 Antibody
 Gpcr91 ELISA Kit
 Gpcr91 Recombinant
 Gpcr91 Antibody
 Lpa1 ELISA Kit
 Lpa1 Recombinant
 Lpa1 Antibody
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Lysophosphatidic acid receptor 1-A

 Lysophosphatidic acid receptor 1-A ELISA Kit
 Lysophosphatidic acid receptor 1-A Recombinant
 Lysophosphatidic acid receptor 1-A Antibody
Also known as Lysophosphatidic acid receptor 1-A (LPA receptor 1-A) (LPA-1-A) (Lysophosphatidic acid receptor LPA1 homolog 1) (xLPA1-1).
Receptor for lysophosphatidic acid (LPA)(PubMed:11278944). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11
>>>
278944). Signaling triggers an increase of cytoplasmic Ca2+ levels. Signaling leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases (). Contributes to the regulation of cell shape (PubMed:11278944). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of Rac. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Promotes cell proliferation in response to lysophosphatidic acid ().
 lpar1-a ELISA Kit
 lpar1-a Recombinant
 lpar1-a Antibody
 lpa1r ELISA Kit
 lpa1r Recombinant
 lpa1r Antibody
 lpa1r1 ELISA Kit
 lpa1r1 Recombinant
 lpa1r1 Antibody
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Lysophosphatidic acid receptor 1-B

 Lysophosphatidic acid receptor 1-B ELISA Kit
 Lysophosphatidic acid receptor 1-B Recombinant
 Lysophosphatidic acid receptor 1-B Antibody
Also known as Lysophosphatidic acid receptor 1-B (LPA receptor 1-B) (LPA-1-B) (Lysophosphatidic acid receptor LPA1 homolog 2) (xLPA1-2).
Receptor for lysophosphatidic acid (LPA)(PubMed:11278944). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:11
>>>
278944). Signaling triggers an increase of cytoplasmic Ca2+ levels. Signaling leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases (). Contributes to the regulation of cell shape (PubMed:11278944). Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of Rac. Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Promotes cell proliferation in response to lysophosphatidic acid ().
 lpar1-b ELISA Kit
 lpar1-b Recombinant
 lpar1-b Antibody
 lpa1r ELISA Kit
 lpa1r Recombinant
 lpa1r Antibody
 lpa1r2 ELISA Kit
 lpa1r2 Recombinant
 lpa1r2 Antibody
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Lysophosphatidic acid receptor 2

 Lysophosphatidic acid receptor 2 ELISA Kit
 Lysophosphatidic acid receptor 2 Recombinant
 Lysophosphatidic acid receptor 2 Antibody
Also known as Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4).
EDG4: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein
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, multi-pass; Receptor, GPCR

Cellular Component: cell surface; endocytic vesicle

Molecular Function: PDZ domain binding

Biological Process: activation of MAPK activity; G-protein coupled receptor protein signaling pathway; positive regulation of MAPKKK cascade; positive regulation of Rho protein signal transduction
 Lpar2 ELISA Kit
 Lpar2 Recombinant
 Lpar2 Antibody
 Edg4 ELISA Kit
 Edg4 Recombinant
 Edg4 Antibody
 Lpa2 ELISA Kit
 Lpa2 Recombinant
 Lpa2 Antibody
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Lysophosphatidic acid receptor 3

 Lysophosphatidic acid receptor 3 ELISA Kit
 Lysophosphatidic acid receptor 3 Recombinant
 Lysophosphatidic acid receptor 3 Antibody
Also known as Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7).
EDG7: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Cellular Component: axon

Molecular Function: G-prote
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in alpha-subunit binding; phospholipid binding

Biological Process: activation of MAPK activity; bleb formation; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); G-protein coupled receptor protein signaling pathway; positive regulation of calcium ion transport; positive regulation of collateral sprouting; positive regulation of MAPKKK cascade
 Lpar3 ELISA Kit
 Lpar3 Recombinant
 Lpar3 Antibody
 Edg7 ELISA Kit
 Edg7 Recombinant
 Edg7 Antibody
 Lpa3 ELISA Kit
 Lpa3 Recombinant
 Lpa3 Antibody
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Lysophosphatidic acid receptor 4

 Lysophosphatidic acid receptor 4 ELISA Kit
 Lysophosphatidic acid receptor 4 Recombinant
 Lysophosphatidic acid receptor 4 Antibody
Also known as Lysophosphatidic acid receptor 4 (LPA receptor 4) (LPA-4) (G-protein coupled receptor 23) (P2Y purinoceptor 9) (P2Y9) (P2Y5-like receptor) (Purinergic receptor 9).
LPAR4: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1- alkyl- > 1-alkenyl-LPA. Belongs to the G-protein coupled receptor 1 family.

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Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: integral to plasma membrane; plasma membrane

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of Rho protein signal transduction
 LPAR4 ELISA Kit
 LPAR4 Recombinant
 LPAR4 Antibody
 GPR23 ELISA Kit
 GPR23 Recombinant
 GPR23 Antibody
 LPA4 ELISA Kit
 LPA4 Recombinant
 LPA4 Antibody
 P2RY9 ELISA Kit
 P2RY9 Recombinant
 P2RY9 Antibody
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Lysophosphatidic acid receptor 5

 Lysophosphatidic acid receptor 5 ELISA Kit
 Lysophosphatidic acid receptor 5 Recombinant
 Lysophosphatidic acid receptor 5 Antibody
Also known as Lysophosphatidic acid receptor 5 (LPA receptor 5) (LPA-5) (G-protein coupled receptor 92).
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.
 LPAR5 ELISA Kit
 LPAR5 Recombinant
 LPAR5 Antibody
 GPR92 ELISA Kit
 GPR92 Recombinant
 GPR92 Antibody
Table BarTOPTable Bar
 

Lysophosphatidic acid receptor 6

 Lysophosphatidic acid receptor 6 ELISA Kit
 Lysophosphatidic acid receptor 6 Recombinant
 Lysophosphatidic acid receptor 6 Antibody
Also known as Lysophosphatidic acid receptor 6 (LPA receptor 6) (LPA-6) (Oleoyl-L-alpha-lysophosphatidic acid receptor) (P2Y purinoceptor 5) (P2Y5) (Purinergic receptor 5).
Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation ().
 LPAR6 ELISA Kit
 LPAR6 Recombinant
 LPAR6 Antibody
 P2RY5 ELISA Kit
 P2RY5 Recombinant
 P2RY5 Antibody
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