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Macrophage-stimulating protein receptor

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.

Below are the list of possible Macrophage-stimulating protein receptor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Macrophage-stimulating protein receptor

 Macrophage-stimulating protein receptor ELISA Kit
 Macrophage-stimulating protein receptor Recombinant
 Macrophage-stimulating protein receptor Antibody
Also known as Macrophage-stimulating protein receptor (MSP receptor) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136).
Ron: a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described.

Protein type: EC; Kinase, protein; Membrane protein, integral; Met family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Lo
cation of Human Ortholog: 3p21.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane

Molecular Function: enzyme binding; macrophage colony stimulating factor receptor activity; protein binding

Biological Process: cell motility; defense response; hepatocyte growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; response to virus; signal transduction; single fertilization

Disease: Nasopharyngeal Carcinoma, Susceptibility To, 3
 MST1R Recombinant
 MST1R Antibody
 PTK8 Recombinant
 PTK8 Antibody
 RON Recombinant
 RON Antibody
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