| Magnesium transporter NIPA4 ELISA Kit|
Magnesium transporter NIPA4 Recombinant
Magnesium transporter NIPA4 Antibody
|Also known as Magnesium transporter NIPA4 (Ichthyin) (NIPA-like protein 4) (Non-imprinted in Prader-Willi/Angelman syndrome region protein 4 homolog). |
ICHN: Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway. Defects in NIPAL4 are the cause of ichthyosis congenital autosomal recessive ichthyin-related (ARCII). ARCII is a disorder of keratinization with abnormal differentiation and desquamation of the epidermis.
The phenotype usually presents as non-bullous congenital ichthyosiform erythroderma (NCIE) with fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Some of the families may show a more lamellar phenotype (lamellar ichthyosis). Belongs to the NIPA family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: cytoplasm; membrane; nucleoplasm
Biological Process: magnesium ion transport
| Nipal4 ELISA Kit|
| Ichn ELISA Kit|
| Nipa4 ELISA Kit|