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Mambalgin

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This three-finger toxin shows a potent analgesic effect against acute and inflammatory pain upon central and peripheral injection. It acts through a reversible block of the heteromeric channel ASIC1a-ASIC2a (ACCN2-ACCN1) in central neurons and of ASIC1b-containing channels in nociceptors. Acts as a gating modifier toxin by binding to the closed/inactivated channel. On channels expressed in COS-7 cells, it shows IC(50) of: 55 nM on rASIC1a, 127 nM on hASIC1a, 246 nM on rASIC1a-rASIC2a, 61 nM on rASIC1a-rASIC2b, 192 nM on ASIC1b, and 72 nM on rASIC1a-rASIC1b.

Below are the list of possible Mambalgin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mambalgin-1

 Mambalgin-1 ELISA Kit
 Mambalgin-1 Recombinant
 Mambalgin-1 Antibody
Also known as Mambalgin-1 (Mamb-1) (Pi-Dp1).
This three-finger toxin shows a potent analgesic effect against acute and inflammatory pain upon central and peripheral injection. It acts through a rev
>>>
ersible block of the heteromeric channel ASIC1a-ASIC2a (ACCN2-ACCN1) in central neurons and of ASIC1b-containing channels in nociceptors. Acts as a gating modifier toxin by binding to the closed/inactivated channel. On channels expressed in COS-7 cells, it shows IC50 of: 55 nM on rASIC1a, 127 nM on hASIC1a, 246 nM on rASIC1a-rASIC2a, 61 nM on rASIC1a-rASIC2b, 192 nM on ASIC1b, and 72 nM on rASIC1a-rASIC1b.
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Mambalgin-2

 Mambalgin-2 ELISA Kit
 Mambalgin-2 Recombinant
 Mambalgin-2 Antibody
Also known as Mambalgin-2 (Ma-2) (Mamb-2) (Pi-Dp2).
This three-finger toxin shows a potent analgesic effect against acute and inflammatory pain upon central and peripheral injection (). It acts thr
>>>
ough a reversible block of the heteromeric channel ASIC1a-ASIC2a (ACCN2-ACCN1) in central neurons and of ASIC1b-containing channels in nociceptors. Acts as a gating modifier toxin by binding to the closed/inactivated channel. On channels expressed in COS-7 cells, it shows IC50 of: 55 nM on rASIC1a, 246 nM on rASIC1a-rASIC2a, 61 nM on rASIC1a-rASIC2b, 192 nM on ASIC1b, and 72 nM on rASIC1a-rASIC1b.
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Mambalgin-3

 Mambalgin-3 ELISA Kit
 Mambalgin-3 Recombinant
 Mambalgin-3 Antibody
Also known as Mambalgin-3 (Mamb-3).
This three-finger toxin shows an analgesic effect against acute and inflammatory pain upon central and peripheral injection. This peptide inhibits rat ASIC1a (IC
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50=17 nM), ASIC1b (IC50= 44 nM) and heteromeric ASIC1a-ASIC2a (IC50=252 nM) channels.
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