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Mannan-binding lectin serine protease

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Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5 (By similarity).

Below are the list of possible Mannan-binding lectin serine protease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mannan-binding lectin serine protease 1

 Mannan-binding lectin serine protease 1 ELISA Kit
 Mannan-binding lectin serine protease 1 Recombinant
 Mannan-binding lectin serine protease 1 Antibody
Also known as Mannan-binding lectin serine protease 1 (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (R.
serine protease that plays a role in the mannan-binding lectin complement pathway [RGD, Feb 2006]
 Masp1 ELISA Kit
 Masp1 Recombinant
 Masp1 Antibody
 Crarf ELISA Kit
 Crarf Recombinant
 Crarf Antibody
 Masp3 ELISA Kit
 Masp3 Recombinant
 Masp3 Antibody
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Mannan-binding lectin serine protease 2

 Mannan-binding lectin serine protease 2 ELISA Kit
 Mannan-binding lectin serine protease 2 Recombinant
 Mannan-binding lectin serine protease 2 Antibody
Also known as Mannan-binding lectin serine protease 2 (MBL-associated serine protease 2) (Mannose-binding protein-associated serine protease 2) (MASP-2).
MASP2: Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3
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convertase. Defects in MASP2 are the cause of MASP2 deficiency (MASPD). MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.104; Protease; Secreted; Secreted, signal peptide

Molecular Function: calcium-dependent protein binding; complement component C4b binding; peptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: complement activation, lectin pathway
 Masp2 ELISA Kit
 Masp2 Recombinant
 Masp2 Antibody
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