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Mastermind-like protein

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Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Below are the list of possible Mastermind-like protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mastermind-like protein 1

 Mastermind-like protein 1 ELISA Kit
 Mastermind-like protein 1 Recombinant
 Mastermind-like protein 1 Antibody
Also known as Mastermind-like protein 1 (Mam-1).
MAML1: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates
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transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Widely expressed with highest levels in heart, pancreas, peripheral blood leukocytes and spleen. Belongs to the mastermind family.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: peptide antigen binding; protein binding; protein kinase binding; transcription coactivator activity

Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transcription initiation from RNA polymerase II promoter
 MAML1 ELISA Kit
 MAML1 Recombinant
 MAML1 Antibody
 KIAA0200 ELISA Kit
 KIAA0200 Recombinant
 KIAA0200 Antibody
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Mastermind-like protein 2

 Mastermind-like protein 2 ELISA Kit
 Mastermind-like protein 2 Recombinant
 Mastermind-like protein 2 Antibody
Also known as Mastermind-like protein 2 (Mam-2).
Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3 ().
 MAML2 ELISA Kit
 MAML2 Recombinant
 MAML2 Antibody
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Mastermind-like protein 3

 Mastermind-like protein 3 ELISA Kit
 Mastermind-like protein 3 Recombinant
 Mastermind-like protein 3 Antibody
Also known as Mastermind-like protein 3 (Mam-3).
MAML3: Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Belongs to the mastermind family.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: nucleoplasm; nucleus

Molecular Function:
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transcription coactivator activity

Biological Process: activation of Notch receptor target transcription factor; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter
 MAML3 ELISA Kit
 MAML3 Recombinant
 MAML3 Antibody
 KIAA1816 ELISA Kit
 KIAA1816 Recombinant
 KIAA1816 Antibody
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