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Matrilin

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Involved in matrix assembly.

Below are the list of possible Matrilin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Matrilin-2

 Matrilin-2 ELISA Kit
 Matrilin-2 Recombinant
 Matrilin-2 Antibody
MATN2: Involved in matrix assembly. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q22

Cellular Component: extracellular matrix

Molecular Function: protein binding
 MATN2 ELISA Kit
 MATN2 Recombinant
 MATN2 Antibody
 UNQ193/PRO219 ELISA Kit
 UNQ193/PRO219 Recombinant
 UNQ193/PRO219 Antibody
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Matrilin-3

 Matrilin-3 ELISA Kit
 Matrilin-3 Recombinant
 Matrilin-3 Antibody
MATN3: Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Defects in MATN3 are the cause of multiple epiphyseal dysplasia type 5 (EDM5). EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms
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. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. EDM5 is relatively mild and clinically variable. It is primarily characterized by delayed and irregular ossification of the epiphyses and early-onset osteoarthritis. Defects in MATN3 are the cause of spondyloepimetaphyseal dysplasia MATN3-related (SEMD-MATN3). A bone disease characterized by disproportionate early-onset dwarfism, bowing of the lower limbs, lumbar lordosis and normal hands. Skeletal abnormalities include short, wide and stocky long bones with severe epiphyseal and metaphyseal changes, hypoplastic iliac bones and flat, ovoid vertebral bodies. Genetic variations in MATN3 are associated with susceptibility to osteoarthritis type 2 (OS2); also called osteoarthritis of distal interphalangeal joints (OADIP) or hand osteoarthritis (HOA). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. In the hand, osteoarthritis can develop in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints. Patients with osteoarthritis may have one, a few, or all of these sites affected.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p24-p23

Cellular Component: extracellular region

Molecular Function: extracellular matrix structural constituent; protein binding

Biological Process: extracellular matrix organization and biogenesis; skeletal development

Disease: Epiphyseal Dysplasia, Multiple, 5; Osteoarthritis Susceptibility 2; Spondyloepimetaphyseal Dysplasia, Matrilin-3 Related
 MATN3 ELISA Kit
 MATN3 Recombinant
 MATN3 Antibody
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Matrilin-4

 Matrilin-4 ELISA Kit
 Matrilin-4 Recombinant
 Matrilin-4 Antibody
MATN4: Major component of the extracellular matrix of cartilage. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: extracellular matrix organization a
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nd biogenesis
 MATN4 ELISA Kit
 MATN4 Recombinant
 MATN4 Antibody
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