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Meckelin

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Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc).

Below are the list of possible Meckelin products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Meckelin

 Meckelin ELISA Kit
 Meckelin Recombinant
 Meckelin Antibody
Also known as Meckelin (Meckel syndrome type 3 protein homolog) (Transmembrane protein 67).
TMEM67: a protein localizes to the primary cilium and to the plasma membrane. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome dupl
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ication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Defects in this protein are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. Interacts with DNAJB9, DNAJC10, MKS1 and mutated SFTPC. Interacts with SYNE2 during the early establishment of cell polarity.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: centrosome; cilium; cytoplasmic vesicle membrane; endoplasmic reticulum membrane

Molecular Function: filamin binding; misfolded protein binding; unfolded protein binding

Biological Process: branching morphogenesis of a tube; determination of left/right symmetry; ER-associated protein catabolic process; heart development

Disease: Bardet-biedl Syndrome 1
 Tmem67 ELISA Kit
 Tmem67 Recombinant
 Tmem67 Antibody
 Mks3 ELISA Kit
 Mks3 Recombinant
 Mks3 Antibody
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