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Meiosis-specific kinetochore protein

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Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Below are the list of possible Meiosis-specific kinetochore protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Meiosis-specific kinetochore protein

 Meiosis-specific kinetochore protein ELISA Kit
 Meiosis-specific kinetochore protein Recombinant
 Meiosis-specific kinetochore protein Antibody
MEIKIN: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono- orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from th
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e same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichemnt to kinetochores. Not required during meiosis II or mitosis. {ECO:0000250|UniProtKB:Q5F2C3}. Interacts with CENPC. Interacts with PLK1; required for recruitment of PLK1 at kinetochores. {ECO:0000250|UniProtKB:Q5F2C3}

Cellular Component: condensed nuclear chromosome, pericentric region

Molecular Function: protein binding

Biological Process: female meiosis chromosome segregation; homologous chromosome segregation; male meiosis chromosome segregation; meiotic sister chromatid cohesion, centromeric
 Meikin ELISA Kit
 Meikin Recombinant
 Meikin Antibody
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