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Melanocortin-2 receptor accessory protein

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Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.

Below are the list of possible Melanocortin-2 receptor accessory protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Melanocortin-2 receptor accessory protein

 Melanocortin-2 receptor accessory protein ELISA Kit
 Melanocortin-2 receptor accessory protein Recombinant
 Melanocortin-2 receptor accessory protein Antibody
Also known as Melanocortin-2 receptor accessory protein (B27) (Fat cell-specific low molecular weight protein) (Fat tissue-specific low MW protein).
MRAP: Required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. May be involved in the intracellular trafficking pathways in adipocyte cells. Defects in MRAP are the cause of glucocorticoid deficiency type 2 (GCCD2); also known as familial glucocorticoid deficiency type 2 (FGD2). GCCD2 is an autosomal recessive disorder due to congenital insensitivity or resistance to
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adrenocorticotropin (ACTH). It is characterized by progressive primary adrenal insufficiency, without mineralocorticoid deficiency. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.1

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: adrenocorticotropin hormone receptor binding; protein binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor binding

Biological Process: positive regulation of cAMP biosynthetic process

Disease: Glucocorticoid Deficiency 2
 MRAP ELISA Kit
 MRAP Recombinant
 MRAP Antibody
 C21orf61 ELISA Kit
 C21orf61 Recombinant
 C21orf61 Antibody
 FALP ELISA Kit
 FALP Recombinant
 FALP Antibody
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Melanocortin-2 receptor accessory protein 2

 Melanocortin-2 receptor accessory protein 2 ELISA Kit
 Melanocortin-2 receptor accessory protein 2 Recombinant
 Melanocortin-2 receptor accessory protein 2 Antibody
MRAP2: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R.
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May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. Belongs to the MRAP family. Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R

Cellular Component: endoplasmic reticulum; plasma membrane

Molecular Function: adrenocorticotropin hormone receptor binding; type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; type 5 melanocortin receptor binding

Biological Process: energy reserve metabolic process; feeding behavior; positive regulation of cAMP biosynthetic process
 Mrap2 ELISA Kit
 Mrap2 Recombinant
 Mrap2 Antibody
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Melanocortin-2 receptor accessory protein 2A

 Melanocortin-2 receptor accessory protein 2A ELISA Kit
 Melanocortin-2 receptor accessory protein 2A Recombinant
 Melanocortin-2 receptor accessory protein 2A Antibody
Also known as Melanocortin-2 receptor accessory protein 2A (zMRAP2a).
Inhibitor of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role during larval development in the control of energy homeostasis and body weight regulation by decreasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP, leading to stimulate growth during larval development. Ac
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ts by stabilizing an inactive conformation of mc4r during embryonic development, when all the energy consumed is obtained from the yolk sac, possibly to speed the rapid maturation to the mobile free-feeding juvenile stage reached at 5 dpf.
 mrap2a ELISA Kit
 mrap2a Recombinant
 mrap2a Antibody
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Melanocortin-2 receptor accessory protein 2B

 Melanocortin-2 receptor accessory protein 2B ELISA Kit
 Melanocortin-2 receptor accessory protein 2B Recombinant
 Melanocortin-2 receptor accessory protein 2B Antibody
Also known as Melanocortin-2 receptor accessory protein 2B (zMRAP2b).
Activator of melanocortin receptor 4 (mc4r), a receptor involved in energy homeostasis. Plays a role after larval development in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of mc4r and mc4r-mediated generation of cAMP once the zebrafish begins feeding, increasing the capacity
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for regulated feeding and growth.
 mrap2b ELISA Kit
 mrap2b Recombinant
 mrap2b Antibody
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