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Membrane-bound transcription factor site-1 protease

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Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes (By similarity).

Below are the list of possible Membrane-bound transcription factor site-1 protease products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Membrane-bound transcription factor site-1 protease

 Membrane-bound transcription factor site-1 protease ELISA Kit
 Membrane-bound transcription factor site-1 protease Recombinant
 Membrane-bound transcription factor site-1 protease Antibody
Also known as Membrane-bound transcription factor site-1 protease (Endopeptidase S1P) (Sterol-regulated luminal protease) (Subtilisin/kexin isozyme 1) (SKI-1).
MBTPS1: Catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His- Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Belongs to the peptidase S8 fam
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ily.

Protein type: EC 3.4.21.112; Endoplasmic reticulum; Membrane protein, integral; Protease

Cellular Component: Golgi apparatus; Golgi stack

Molecular Function: endopeptidase activity; serine-type endopeptidase activity

Biological Process: lipid metabolic process; lysosome organization and biogenesis; proteolysis; regulation of transcription factor import into nucleus
 Mbtps1 ELISA Kit
 Mbtps1 Recombinant
 Mbtps1 Antibody
 S1p ELISA Kit
 S1p Recombinant
 S1p Antibody
 Ski1 ELISA Kit
 Ski1 Recombinant
 Ski1 Antibody
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