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Metastasis-associated protein

Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Plays a role in the inflammatory responses, both as a target and as a component of the NF-kappa-B signaling and regulates a subset of proinflammatory cytokines such as IL1B, MIP2, and TNF. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression.

Below are the list of possible Metastasis-associated protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Metastasis-associated protein MTA1

 Metastasis-associated protein MTA1 ELISA Kit
 Metastasis-associated protein MTA1 Recombinant
 Metastasis-associated protein MTA1 Antibody
MTA1: metastasis-associated protein. A component of the NuRD ATP-dependent chromatin remodeling and histone deacetylase complex. Interacts with HDAC1. Expressed at high levels in metastatic cells. Two alternatively spliced isoforms have been described. The long isoform is a co-repressor of estrogen receptor (ER). The short isoform binds to ER and sequesters it in the cytoplasm and enhances non-gen
omic responses of ER.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; intracellular membrane-bound organelle; microtubule; nuclear envelope; nucleoplasm; nucleus; NuRD complex

Molecular Function: protein binding; transcription coactivator activity; transcription corepressor activity

Biological Process: circadian regulation of gene expression; double-strand break repair; entrainment of circadian clock by photoperiod; locomotor rhythm; proteasomal ubiquitin-dependent protein catabolic process; regulation of gene expression, epigenetic; regulation of inflammatory response; response to ionizing radiation; response to lipopolysaccharide
 Mta1 ELISA Kit
 Mta1 Recombinant
 Mta1 Antibody
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Metastasis-associated protein MTA2

 Metastasis-associated protein MTA2 ELISA Kit
 Metastasis-associated protein MTA2 Recombinant
 Metastasis-associated protein MTA2 Antibody
Also known as Metastasis-associated protein MTA2 (Metastasis-associated 1-like 1).
MTA2: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Protein type: DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor

Cellular Comp
onent: histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; NuRD complex; protein complex; transcription factor complex

Molecular Function: histone deacetylase activity; histone deacetylase binding; nucleosomal DNA binding; protein binding

Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; DNA methylation; DNA packaging; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter
 Mta2 ELISA Kit
 Mta2 Recombinant
 Mta2 Antibody
 Mta1l1 ELISA Kit
 Mta1l1 Recombinant
 Mta1l1 Antibody
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Metastasis-associated protein MTA3

 Metastasis-associated protein MTA3 ELISA Kit
 Metastasis-associated protein MTA3 Recombinant
 Metastasis-associated protein MTA3 Antibody
MTA3: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: in
tracellular membrane-bound organelle; nucleoplasm; nucleus

Molecular Function: histone deacetylase activity; protein binding

Biological Process: negative regulation of transcription, DNA-dependent
 MTA3 Recombinant
 MTA3 Antibody
 KIAA1266 Recombinant
 KIAA1266 Antibody
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