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Methyl-CpG-binding domain protein

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Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

Below are the list of possible Methyl-CpG-binding domain protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Methyl-CpG-binding domain protein 1

 Methyl-CpG-binding domain protein 1 ELISA Kit
 Methyl-CpG-binding domain protein 1 Recombinant
 Methyl-CpG-binding domain protein 1 Antibody
Also known as Methyl-CpG-binding domain protein 1 (CXXC-type zinc finger protein 3) (Methyl-CpG-binding protein MBD1) (Protein containing methyl-CpG-binding domain 1).
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions;
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several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
 MBD1 ELISA Kit
 MBD1 Recombinant
 MBD1 Antibody
 CXXC3 ELISA Kit
 CXXC3 Recombinant
 CXXC3 Antibody
 PCM1 ELISA Kit
 PCM1 Recombinant
 PCM1 Antibody
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Methyl-CpG-binding domain protein 2

 Methyl-CpG-binding domain protein 2 ELISA Kit
 Methyl-CpG-binding domain protein 2 Recombinant
 Methyl-CpG-binding domain protein 2 Antibody
Also known as Methyl-CpG-binding domain protein 2 (Demethylase) (DMTase) (Methyl-CpG-binding protein MBD2).
MBD2: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. May enhanc
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e the activation of some unmethylated cAMP-responsive promoters. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q21

Cellular Component: nuclear chromatin; nucleoplasm; nucleus; protein complex

Molecular Function: methyl-CpG binding; nucleosomal DNA binding; protein binding; protein domain specific binding; satellite DNA binding

Biological Process: ATP-dependent chromatin remodeling; chromatin silencing at rDNA; methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter
 MBD2 ELISA Kit
 MBD2 Recombinant
 MBD2 Antibody
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Methyl-CpG-binding domain protein 3

 Methyl-CpG-binding domain protein 3 ELISA Kit
 Methyl-CpG-binding domain protein 3 Recombinant
 Methyl-CpG-binding domain protein 3 Antibody
Also known as Methyl-CpG-binding domain protein 3 (Methyl-CpG-binding protein MBD3).
MBD3: methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role i
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n histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target.

Protein type: Gene silencing; Transcription, coactivator/corepressor

Cellular Component: chromatin; cytoplasm; heterochromatin; nuclear chromatin; nucleolus; nucleus; NuRD complex; protein complex

Molecular Function: chromatin binding; DNA binding; methyl-CpG binding; nucleosomal DNA binding; protein binding

Biological Process: ATP-dependent chromatin remodeling; histone acetylation; in utero embryonic development; methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter; tissue development
 Mbd3 ELISA Kit
 Mbd3 Recombinant
 Mbd3 Antibody
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Methyl-CpG-binding domain protein 3-like 1

 Methyl-CpG-binding domain protein 3-like 1 ELISA Kit
 Methyl-CpG-binding domain protein 3-like 1 Recombinant
 Methyl-CpG-binding domain protein 3-like 1 Antibody
Also known as Methyl-CpG-binding domain protein 3-like 1 (MBD3-like protein 1).
MBD3L1: Transcriptional repressor. Belongs to the MBD3L family.

Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane

Molecular Function: methyl-CpG binding

Biological Process: methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II p
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romoter
 Mbd3l1 ELISA Kit
 Mbd3l1 Recombinant
 Mbd3l1 Antibody
 Mbd3l ELISA Kit
 Mbd3l Recombinant
 Mbd3l Antibody
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Methyl-CpG-binding domain protein 3-like 2

 Methyl-CpG-binding domain protein 3-like 2 ELISA Kit
 Methyl-CpG-binding domain protein 3-like 2 Recombinant
 Methyl-CpG-binding domain protein 3-like 2 Antibody
Also known as Methyl-CpG-binding domain protein 3-like 2 (MBD3-like protein 2).
MBD3L2: a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein has been found in germ cell tumors and some somatic tissues. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: nucleus

Molecular
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Function: methyl-CpG binding

Biological Process: methylation-dependent chromatin silencing; negative regulation of transcription from RNA polymerase II promoter
 MBD3L2 ELISA Kit
 MBD3L2 Recombinant
 MBD3L2 Antibody
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Methyl-CpG-binding domain protein 4

 Methyl-CpG-binding domain protein 4 ELISA Kit
 Methyl-CpG-binding domain protein 4 Recombinant
 Methyl-CpG-binding domain protein 4 Antibody
Also known as Methyl-CpG-binding domain protein 4 (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase).
MBD4: Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches
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. Has no lyase activity. Was first identified as methyl-CpG-binding protein. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.-

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: chromatin; nucleoplasm; nucleus

Molecular Function: DNA N-glycosylase activity; endodeoxyribonuclease activity; protein binding; pyrimidine-specific mismatch base pair DNA N-glycosylase activity; satellite DNA binding

Biological Process: depyrimidination; DNA repair; response to radiation
 MBD4 ELISA Kit
 MBD4 Recombinant
 MBD4 Antibody
 MED1 ELISA Kit
 MED1 Recombinant
 MED1 Antibody
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Methyl-CpG-binding domain protein 5

 Methyl-CpG-binding domain protein 5 ELISA Kit
 Methyl-CpG-binding domain protein 5 Recombinant
 Methyl-CpG-binding domain protein 5 Antibody
Also known as Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5).
MBD5: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Defects in MBD5 are the cause of mental retardation autosomal dominant type 1 (MRD1). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairm
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ents in adaptative behavior and manifested during the developmental period. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Cellular Component: chromocenter; nucleus

Molecular Function: chromatin binding

Biological Process: glucose homeostasis; nervous system development; regulation of multicellular organism growth
 Mbd5 ELISA Kit
 Mbd5 Recombinant
 Mbd5 Antibody
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Methyl-CpG-binding domain protein 6

 Methyl-CpG-binding domain protein 6 ELISA Kit
 Methyl-CpG-binding domain protein 6 Recombinant
 Methyl-CpG-binding domain protein 6 Antibody
Also known as Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).
MBD6: Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro).

Chromosomal Location of Human Ortholog: -

Cellular Component: chromocenter; nucleolus; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding
 MBD6 ELISA Kit
 MBD6 Recombinant
 MBD6 Antibody
 KIAA1887 ELISA Kit
 KIAA1887 Recombinant
 KIAA1887 Antibody
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