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Methyl-CpG-binding protein

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Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Below are the list of possible Methyl-CpG-binding protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Methyl-CpG-binding protein 2

 Methyl-CpG-binding protein 2 ELISA Kit
 Methyl-CpG-binding protein 2 Recombinant
 Methyl-CpG-binding protein 2 Antibody
Also known as Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2).
MECP2: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Interacts with FNBP3. Interacts with CDKL5. Prese
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nt in all adult somatic tissues tested. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Cellular Component: cytoplasm; cytosol; extracellular space; heterochromatin; nuclear chromatin; nucleus; protein complex

Molecular Function: chromatin binding; chromatin DNA binding; DNA binding; double-stranded methylated DNA binding; enzyme binding; four-way junction DNA binding; histone deacetylase binding; methyl-CpG binding; mRNA binding; protein binding; protein domain specific binding; protein N-terminus binding; siRNA binding; transcription factor activity; transcription factor binding; unmethylated CpG binding

Biological Process: adult locomotory behavior; behavioral fear response; biogenic amine metabolic process; brain development; cardiolipin metabolic process; catecholamine secretion; cerebellum development; chromatin silencing; dendrite development; embryonic development; genetic imprinting; glucocorticoid metabolic process; glutamine metabolic process; histone acetylation; histone methylation; inositol metabolic process; learning; long-term memory; memory; mitochondrial electron transport, ubiquinol to cytochrome c; multicellular organismal response to stress; negative regulation of astrocyte differentiation; negative regulation of histone acetylation; negative regulation of histone methylation; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neurite development; neurological control of breathing; neuromuscular process; neuromuscular process controlling posture; neuron differentiation; neuron maturation; pathogenesis; phosphatidylcholine metabolic process; positive regulation of cell proliferation; positive regulation of synaptogenesis; positive regulation of transcription, DNA-dependent; post-embryonic development; proprioception; protein localization; regulation of excitatory postsynaptic membrane potential; regulation of gene expression; regulation of gene expression, epigenetic; regulation of synaptic plasticity; regulation of systemic arterial blood pressure by neurological process; regulation of transcription, DNA-dependent; respiratory gaseous exchange; response to hypoxia; sensory perception of pain; social behavior; startle response; synaptic transmission; synaptogenesis; ventricular system development; visual learning
 Mecp2 ELISA Kit
 Mecp2 Recombinant
 Mecp2 Antibody
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