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Methylcytosine dioxygenase

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Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis .

Below are the list of possible Methylcytosine dioxygenase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Methylcytosine dioxygenase TET1

 Methylcytosine dioxygenase TET1 ELISA Kit
 Methylcytosine dioxygenase TET1 Recombinant
 Methylcytosine dioxygenase TET1 Antibody
Also known as Methylcytosine dioxygenase TET1 (CXXC-type zinc finger protein 6) (Leukemia-associated protein with a CXXC domain) (Ten-eleven translocation 1 gene protein).
TET1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the
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mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'. Belongs to the TET family.

Protein type: DNA-binding; EC 1.14.11.n2; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: nucleus

Molecular Function: iron ion binding; structure-specific DNA binding

Biological Process: 5-methylcytosine catabolic process; inner cell mass cell differentiation; positive regulation of cell proliferation; positive regulation of histone methylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid O-linked glycosylation; stem cell maintenance
 TET1 ELISA Kit
 TET1 Recombinant
 TET1 Antibody
 CXXC6 ELISA Kit
 CXXC6 Recombinant
 CXXC6 Antibody
 KIAA1676 ELISA Kit
 KIAA1676 Recombinant
 KIAA1676 Antibody
 LCX ELISA Kit
 LCX Recombinant
 LCX Antibody
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Methylcytosine dioxygenase TET2

 Methylcytosine dioxygenase TET2 ELISA Kit
 Methylcytosine dioxygenase TET2 Recombinant
 Methylcytosine dioxygenase TET2 Antibody
TET2: Catalyzes the conversion of methylcytosine (5mC) to 5- hydroxymethylcytosine (hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 is frequently mutated in myeloproliferative disorders (MPD). These constitute a heterogeneous group of disorders, also known as myeloproliferative diseases or myeloproliferative neoplasms (MPN), characterized by cellular proliferation of one or more hema
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tologic cell lines in the peripheral blood, distinct from acute leukemia. Included diseases are: essential thrombocythemia, polycythemia vera, primary myelofibrosis (chronic idiopathic myelofibrosis). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. Defects in TET2 are a cause of polycythemia vera (PV). A myeloproliferative disorder characterized by abnormal proliferation of all hematopoietic bone marrow elements, erythroid hyperplasia, an absolute increase in total blood volume, but also by myeloid leukocytosis, thrombocytosis and splenomegaly. TET2 is frequently mutated in systemic mastocytosis; also known as systemic mast cell disease. A condition with features in common with myeloproliferative diseases. It is a clonal disorder of the mast cell and its precursor cells. The clinical symptoms and signs of systemic mastocytosis are due to accumulation of clonally derived mast cells in different tissues, including bone marrow, skin, the gastrointestinal tract, the liver, and the spleen. Defects in TET2 are a cause of myelodysplastic syndrome (MDS). A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS). Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. Myelodysplastic syndromes are considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.n2; Oxidoreductase; Tumor suppressor

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: nucleus

Molecular Function: ferrous iron binding; protein binding; zinc ion binding

Biological Process: 5-methylcytosine catabolic process; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid O-linked glycosylation

Disease: Myelodysplastic Syndrome
 TET2 ELISA Kit
 TET2 Recombinant
 TET2 Antibody
 KIAA1546 ELISA Kit
 KIAA1546 Recombinant
 KIAA1546 Antibody
 Nbla00191 ELISA Kit
 Nbla00191 Recombinant
 Nbla00191 Antibody
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Methylcytosine dioxygenase TET3

 Methylcytosine dioxygenase TET3 ELISA Kit
 Methylcytosine dioxygenase TET3 Recombinant
 Methylcytosine dioxygenase TET3 Antibody
TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmeth
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ylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.n2; Oxidoreductase

Cellular Component: cytoplasm; female pronucleus; male pronucleus; nucleus

Molecular Function: iron ion binding; protein binding

Biological Process: 5-methylcytosine catabolic process; positive regulation of transcription from RNA polymerase II promoter; protein amino acid O-linked glycosylation
 Tet3 ELISA Kit
 Tet3 Recombinant
 Tet3 Antibody
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