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Methylosome protein

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Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Below are the list of possible Methylosome protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Methylosome protein 50

 Methylosome protein 50 ELISA Kit
 Methylosome protein 50 Recombinant
 Methylosome protein 50 Antibody
Also known as Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50).
WDR77: a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory
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modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: cytoplasm; cytosol; Golgi apparatus; nucleoplasm; nucleus

Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; methyl-CpG binding; protein binding; protein-arginine N-methyltransferase activity

Biological Process: spliceosomal snRNP biogenesis
 WDR77 ELISA Kit
 WDR77 Recombinant
 WDR77 Antibody
 MEP50 ELISA Kit
 MEP50 Recombinant
 MEP50 Antibody
 WD45 ELISA Kit
 WD45 Recombinant
 WD45 Antibody
 HKMT1069 ELISA Kit
 HKMT1069 Recombinant
 HKMT1069 Antibody
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