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Methyltransferase

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Methyltransferase; part of the gene cluster that mediates the biosynthesis of aflavarin, a bicoumarin that exhibits anti-insectan activity against the fungivorous beetle C.hemipterus (Ref.2, PubMed:26209694).

Below are the list of possible Methyltransferase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Methyltransferase afvD

 Methyltransferase afvD ELISA Kit
 Methyltransferase afvD Recombinant
 Methyltransferase afvD Antibody
Also known as Methyltransferase afvD (Aflavarin synthesis protein D).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of aflavarin, a bicoumarin that exhibits anti-insectan activity against the fungivorous beetle C.hemipterus (Ref. 2, PubMed:26209694).
 afvD ELISA Kit
 afvD Recombinant
 afvD Antibody
 AFLA_108570 ELISA Kit
 AFLA_108570 Recombinant
 AFLA_108570 Antibody
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Methyltransferase ausD

 Methyltransferase ausD ELISA Kit
 Methyltransferase ausD Recombinant
 Methyltransferase ausD Antibody
Also known as Methyltransferase ausD (Austinol synthesis protein D).
Methyltransferase; part of the gene cluster A that mediates the biosynthesis of austinol and dehydroaustinol, two fungal meroterpenoids (PubMed:22329759). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid by the polyketide synthase ausA (PubMed:22329759). 3,5-dimethylorsellinic acid is then prenylat
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ed by the polyprenyl transferase ausN (PubMed:22329759). Further epoxidation by the FAD-dependent monooxygenase ausM and cyclization by the probable terpene cyclase ausL lead to the formation of protoaustinoid A (PubMed:22329759). Protoaustinoid A is then oxidized to spiro-lactone preaustinoid A3 by the combined action of the FAD-binding monooxygenases ausB and ausC, and the dioxygenase ausE (PubMed:22329759, PubMed:23865690). Acid-catalyzed keto-rearrangement and ring contraction of the tetraketide portion of preaustinoid A3 by ausJ lead to the formation of preaustinoid A4 (PubMed:22329759). The aldo-keto reductase ausK, with the help of ausH, is involved in the next step by transforming preaustinoid A4 into isoaustinone which is in turn hydroxylated by the P450 monooxygenase ausI to form austinolide (PubMed:22329759). Finally, the cytochrome P450 monooxygenase ausG modifies austinolide to austinol (PubMed:22329759). Austinol can be further modified to dehydroaustinol which forms a diffusible complex with diorcinol that initiates conidiation (PubMed:22234162, PubMed:22329759). The exact role of ausD within the pathway has not been identified yet (PubMed:22329759).
 ausD ELISA Kit
 ausD Recombinant
 ausD Antibody
 AN8384 ELISA Kit
 AN8384 Recombinant
 AN8384 Antibody
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Methyltransferase ctvB

 Methyltransferase ctvB ELISA Kit
 Methyltransferase ctvB Recombinant
 Methyltransferase ctvB Antibody
Also known as Methyltransferase ctvB (Citreoviridin biosynthesis protein B).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of citreoviridin, an inhibitor of the of F1-ATPase beta-subunit (PubMed:26954888). The HR-PKS ctvA accepts acetyl-CoA as the starter unit and catalyzes eight iterations of malonyl-CoA extension and four iterations of SAM-dependent methylation at
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C4, C12, C14, and C16 (PubMed:26954888). The KR and DH domains selectively act on the first six iterations to generate the hexaene chain (PubMed:26954888). In the last three iterations, the KR and DH domains terminate their functions to yield a beta,delta-diketo ester moiety, which then undergoes intramolecular cyclization to yield an alpha-pyrone intermediate (PubMed:26954888). Subsequently, ctvB methylates the alpha-pyrone hydroxyl group to generate citreomontanin (PubMed:26954888). In order to form the tetrahydrofuran ring with the correct stereochemistry, the terminal alkenes of citreomontanin need to undergo isomerization to yield a (17Z)-hexaene, a step that could be catalyzed by ctvC (PubMed:26954888). The (17Z)-hexaene then undergoes bisepoxidation by ctvC to form a (17R,16R,15S,14R)-bisepoxide moiety (PubMed:26954888). Lastly, ctvD acts as a regioselective hydrolase to form the tetrahydrofuran ring with the substituents in the correct absolute configuration, completing the biosynthesis of citreoviridin (PubMed:26954888).
 ctvB ELISA Kit
 ctvB Recombinant
 ctvB Antibody
 ATEG_09618 ELISA Kit
 ATEG_09618 Recombinant
 ATEG_09618 Antibody
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Methyltransferase Dmt

 Methyltransferase Dmt ELISA Kit
 Methyltransferase Dmt Recombinant
 Methyltransferase Dmt Antibody
Methyltransferase that methylates adenine residues in the dsDNA sequence GATC. Essential for genome packaging because it methylates GATC sequences within the pac site making the latter cleavable (PubMed:3312202, PubMed:2236019). May prevents degradation of viral DNA by the host restriction-modification antiviral defense system (PubMed:376871).
 dmt ELISA Kit
 dmt Recombinant
 dmt Antibody
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Methyltransferase FUS9

 Methyltransferase FUS9 ELISA Kit
 Methyltransferase FUS9 Recombinant
 Methyltransferase FUS9 Antibody
Also known as Methyltransferase FUS9 (Fusarin biosynthesis protein 9).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:17121404, PubMed:22652150). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (). The roles of the other FUS members are yet undetermined (). The fusarin C synthetase FUS1 is respons
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ible for the condensation of one acetyl-coenzyme A (CoA) unit with six malonyl-CoA units and the amide linkage of the arising heptaketide and homoserine, subsequently releasing the first intermediate, prefusarin, as an alcohol with an open ring structure (PubMed:17121404). The cytochrome P450 monooxygenase FUS8 participates in multiple oxidation processes at carbon C-20 and is able to use the FUS1 product as substrate, resulting in formation of 20-hydroxy-prefusarin (). This reaction seems to be essential before the 2-pyrrolidone ring closure can be catalyzed by FUS2, generating 20-hydroxy-fusarin (). FUS8 is able to further oxidizes carbon C-20 after ring closure, resulting in the formation of carboxy-fusarin C (). As the last step, FUS9 methylates the hydroxyl group at C-21 to generate fusarin C (). Fusarin C can then rearrange to epi-fusarin C, the (z)-isomers, and fusarin A and fusarin D ().
 FUS9 ELISA Kit
 FUS9 Recombinant
 FUS9 Antibody
 FVEG_11078 ELISA Kit
 FVEG_11078 Recombinant
 FVEG_11078 Antibody
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Methyltransferase gedG

 Methyltransferase gedG ELISA Kit
 Methyltransferase gedG Recombinant
 Methyltransferase gedG Antibody
Also known as Methyltransferase gedG (Geodin synthesis protein G).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of geodin, an intermediate in the biosynthesis of other natural products (PubMed:7665560, PubMed:19549600, PubMed:24009710). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) gedC (PubMed:12536215, PubMed:195
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49600). The atrochrysone carboxyl ACP thioesterase gedB then breaks the thioester bond and releases the atrochrysone carboxylic acid from gedC (PubMed:19549600). The atrochrysone carboxylic acid is then converted to atrochrysone which is further transformed into emodinanthrone (PubMed:24009710). The next step is performed by the emodinanthrone oxygenase gedH that catalyzes the oxidation of emodinanthrone to emodin (PubMed:1810248). Emodin O-methyltransferase encoded probably by gedA then catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:1444712). Ring cleavage of questin by questin oxidase gedK leads to desmethylsulochrin via several intermediates including questin epoxide (PubMed:3182756). Another methylation step probably catalyzed by methyltransferase gedG leads to the formation of sulochrin which is further converted to dihydrogeodin by the sulochrin halogenase gedL (PubMed:24009710). Finally, the dihydrogeodin oxidase gedJ catalyzes the stereospecific phenol oxidative coupling reaction converting dihydrogeodin to geodin (PubMed:7665560).
 gedG ELISA Kit
 gedG Recombinant
 gedG Antibody
 ATEG_08456 ELISA Kit
 ATEG_08456 Recombinant
 ATEG_08456 Antibody
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Methyltransferase OMS1

 Methyltransferase OMS1 ELISA Kit
 Methyltransferase OMS1 Recombinant
 Methyltransferase OMS1 Antibody
Also known as Methyltransferase OMS1, mitochondrial (OXA1 multicopy suppressor 1).
Mitochondrial methyltransferase which suppresses respiratory defects caused by OXA1 mutations when overexpressed.
 OMS1 ELISA Kit
 OMS1 Recombinant
 OMS1 Antibody
 YDR316W ELISA Kit
 YDR316W Recombinant
 YDR316W Antibody
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Methyltransferase psoC

 Methyltransferase psoC ELISA Kit
 Methyltransferase psoC Recombinant
 Methyltransferase psoC Antibody
Also known as Methyltransferase psoC (Pseurotin biosynthesis protein C).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of pseurotin A, a competitive inhibitor of chitin synthase and an inducer of nerve-cell proliferation (PubMed:24082142, PubMed:24939566). The PKS-NRPS hybrid synthetase psoA is responsible for the biosynthesis of azaspirene, one of the first interme
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diates having the 1-oxa-7-azaspiro[4,4]-non-2-ene-4,6-dione core of pseurotin, via condensation of one acetyl-CoA, 4 malonyl-CoA, and a L-phenylalanine molecule (PubMed:24082142, PubMed:24939566). The dual-functional monooxygenase/methyltransferase psoF seems to be involved in the addition of the C3 methyl group onto the pseurotin scaffold (PubMed:24939566). Azaspirene is then converted to synerazol through 4 steps including oxidation of C17 by the cytochrome P450 monooxygenase psoD, O-methylation of the hydroxy group of C8 by the methyltransferase psoC, and the trans-to-cis isomerization of the C13 olefin by the glutathione S-transferase psoE (PubMed:24939566). The fourth step of synerazol production is performed by the dual-functional monooxygenase/methyltransferase psoF which seems to catalyze the epoxidation of the intermediate deepoxy-synerazol (PubMed:24939566). Synerazol can be attacked by a water molecule nonenzymatically at two different positions to yield two diol products, pseurotin A and pseurotin D (PubMed:24939566).
 psoC ELISA Kit
 psoC Recombinant
 psoC Antibody
 AFUA_8G00550 ELISA Kit
 AFUA_8G00550 Recombinant
 AFUA_8G00550 Antibody
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Methyltransferase tpcH

 Methyltransferase tpcH ELISA Kit
 Methyltransferase tpcH Recombinant
 Methyltransferase tpcH Antibody
Also known as Methyltransferase tpcH (Trypacidin synthesis protein H).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966). The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966). The decarboxylase tpcK converts atroch
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rysone carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966). The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966). Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966). Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966). Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H2O2), thus triggering host necrotic cell death (PubMed:22319557). The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
 tpcH ELISA Kit
 tpcH Recombinant
 tpcH Antibody
 tynH ELISA Kit
 tynH Recombinant
 tynH Antibody
 AFUA_4G14510 ELISA Kit
 AFUA_4G14510 Recombinant
 AFUA_4G14510 Antibody
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Methyltransferase tpcM

 Methyltransferase tpcM ELISA Kit
 Methyltransferase tpcM Recombinant
 Methyltransferase tpcM Antibody
Also known as Methyltransferase tpcM (Geodin synthesis protein G).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of trypacidin, a mycotoxin with antiprotozoal activity and that plays a role in the infection process (PubMed:26278536, PubMed:26242966). The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase (PKS) tpcC (PubMed:26242966). The atrochrysone carboxyl ACP thioesterase tpcB then breaks the thioester bond and releases the atrochrysone carboxylic acid from tpcC (PubMed:26242966). The decarboxylase tpcK converts atrochryso
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ne carboxylic acid to atrochrysone which is further reduced into emodin anthrone (PubMed:26242966). The next step is performed by the emodin anthrone oxygenase tpcL that catalyzes the oxidation of emodinanthrone to emodin (PubMed:26242966). Emodin O-methyltransferase encoded by tpcA catalyzes methylation of the 8-hydroxy group of emodin to form questin (PubMed:26242966). Ring cleavage of questin by questin oxidase tpcI leads to desmethylsulochrin via several intermediates including questin epoxide (). Another methylation step catalyzed by tpcM leads to the formation of sulochrin which is further converted to monomethylsulfochrin by tpcH. Finally, the tpcJ catalyzes the conversion of monomethylsulfochrin to trypacidin (PubMed:26242966). Trypacidin is toxic for human pulmonary and bronchial epithelial cells by initiating the intracellular formation of nitric oxide (NO) and hydrogen peroxide (H2O2), thus triggering host necrotic cell death (PubMed:22319557). The trypacidin pathway is also able to produce endocrocin via a distinct route from the endocrocin Enc pathway (PubMed:26242966).
 tpcM ELISA Kit
 tpcM Recombinant
 tpcM Antibody
 tynM ELISA Kit
 tynM Recombinant
 tynM Antibody
 AFUA_4G14460 ELISA Kit
 AFUA_4G14460 Recombinant
 AFUA_4G14460 Antibody
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Methyltransferase trt5

 Methyltransferase trt5 ELISA Kit
 Methyltransferase trt5 Recombinant
 Methyltransferase trt5 Antibody
Also known as Methyltransferase trt5 (Terretonin synthesis protein 5).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of terretonin, a fungal meroterpenoid that acts as a mycotoxin (PubMed:22549923, PubMed:23116177, PubMed:25671343). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase trt4 (PubMed:22549923,
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PubMed:23116177). DMOA is then prenylated into farnesyl-DMOA by the polyprenyl transferase trt2 (PubMed:22549923, PubMed:22782788, PubMed:23116177). Methylation by the methyltransferase trt5 then leads to farnesyl-DMOA methyl ester which is further subject to epoxidation by the FAD-dependent monooxygenase trt8 to yield epoxyfarnesyl-DMOA methyl ester (PubMed:22549923, PubMed:22782788, PubMed:23116177). Cyclization of epoxyfarnesyl-DMOA methyl ester by the terpene cyclase trt1 leads to a tetracycle intermediate which is in turn converted to preterretonin (PubMed:22549923, PubMed:22782788, PubMed:23116177). Dehydrogenase trt9 comes next to transform preterretonin to preterrenoid (PubMed:22549923, PubMed:23116177). The FAD-dependent monooxygenase trt3 is then required for the C-hydroxylation at C16 of preterrenoid to yield terrenoid (PubMed:22549923, PubMed:23116177). The cytochrome P450 trt6 catalyzes three successive oxidations to transform terrenoid into an unstable intermediate, which then undergoes the D-ring expansion and unusual rearrangement of the methoxy group to afford the core skeleton of terretonin (PubMed:25671343). This unprecedented rearrangement is catalyzed by the isomerase trt14 (PubMed:25671343). Finally, the nonheme iron-dependent dioxygenase trt7 accomplishes the last two oxidation reactions steps to complete the biosynthesis of terretonin (PubMed:25671343). Terretonin C is produced via spontaneous decarboxylation of the terretonin precursor (PubMed:23116177). Another shunt product of the terretonin biosynthesis is dihydrofarnesyl-DMOA, derived from epoxyfarnesyl-DMOA through hydrolysis of the epoxide (PubMed:22549923, PubMed:22782788, PubMed:23116177).
 trt5 ELISA Kit
 trt5 Recombinant
 trt5 Antibody
 ATEG_10081 ELISA Kit
 ATEG_10081 Recombinant
 ATEG_10081 Antibody
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Methyltransferase ustM

 Methyltransferase ustM ELISA Kit
 Methyltransferase ustM Recombinant
 Methyltransferase ustM Antibody
Also known as Methyltransferase ustM (Ustiloxin B biosynthesis protein M).
Methyltransferase; part of the gene cluster that mediates the biosynthesis of the secondary metabolite ustiloxin B, an antimitotic tetrapeptide (PubMed:24841822, PubMed:27166860, PubMed:26703898). First, ustA is processed by the subtilisin-like endoprotease Kex2 that is outside the ustiloxin B gene cluster, at the C-term
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inal side of Arg-Lys, after transfer to Golgi apparatus through the endoplasmic reticulum (ER) (PubMed:24841822). Cleavage by KEX2 generates 16 peptides YAIG-I to YAIG-XVI (PubMed:24841822). To process the precursor peptide further, at least two peptidases are necessary to cleave the N-terminal and C-terminal sides of the Tyr-Ala-Ile-Gly core peptide which serves as backbone for the synthesis of ustiloxin B, through cyclization and modification of the tyrosine with a non-protein coding amino acid, norvaline (PubMed:24841822). One of the two peptidases must be the serine peptidase ustP; and the other pepdidase is probably ustH (PubMed:24841822). Macrocyclization of the core peptide derived from ustA requires the tyrosinase ustQ, as well as the homologous oxidases ustYa and ustYb, and leads to the production of the first cyclization product N-desmethylustiloxin F (PubMed:27166860, PubMed:26703898). For the formation of N-desmethylustiloxin F, three oxidation steps are required, hydroxylation at the benzylic position, hydroxylation at either the aromatic ring of Tyr or beta-position of Ile, and oxidative cyclization (PubMed:27166860). UstQ may catalyze the oxidation of a phenol moiety, whereas the ustYa and ustYb are most likely responsible for the remaining two-step oxidations (PubMed:27166860). N-desmethylustiloxin F is then methylated by ustM to yield ustiloxin F which in turn substrate of the cytochrome P450 monooxygenase ustC which catalyzes the formation of S-deoxyustiloxin H (PubMed:27166860). The flavoprotein monooxygenases ustF1 and ustF2 then participate in the modification of the side chain of S-deoxyustiloxin H, leading to the synthesis of an oxime intermediate, via ustiloxin H (PubMed:27166860). Finally, carboxylative dehydration performed by the cysteine desulfurase-like protein ustD yields ustiloxin B (PubMed:27166860).
 ustM ELISA Kit
 ustM Recombinant
 ustM Antibody
 AFLA_095100 ELISA Kit
 AFLA_095100 Recombinant
 AFLA_095100 Antibody
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