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Microphthalmia-associated transcription factor

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Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium (By similarity).

Below are the list of possible Microphthalmia-associated transcription factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Microphthalmia-associated transcription factor

 Microphthalmia-associated transcription factor ELISA Kit
 Microphthalmia-associated transcription factor Recombinant
 Microphthalmia-associated transcription factor Antibody
MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has
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a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Cellular Component: nucleus; protein complex

Molecular Function: chromatin binding; DNA binding; RNA polymerase II transcription factor activity, enhancer binding; transcription factor activity

Biological Process: bone remodeling; camera-type eye development; cell differentiation; cell fate commitment; melanocyte differentiation; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; pigmentation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; regulation of cell proliferation; regulation of gene expression; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; Wnt receptor signaling pathway
 Mitf ELISA Kit
 Mitf Recombinant
 Mitf Antibody
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