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Microtubule-actin cross-linking factor

Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells.

Below are the list of possible Microtubule-actin cross-linking factor products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.

Microtubule-actin cross-linking factor 1

 Microtubule-actin cross-linking factor 1 ELISA Kit
 Microtubule-actin cross-linking factor 1 Recombinant
 Microtubule-actin cross-linking factor 1 Antibody
Also known as Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).
ACF7: a nuclear WD40-repeat protein. An F-actin-binding protein which may play a role in cross- linking actin to other cytoskeletal proteins. Also binds to microtubules. WD40 proteins are known to function as adaptors in pre-mrna processing and cytoskeleton assembly.

Protein type: Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis

Cellular Component: actin cytoskeleton; cell cortex; cytoplasm; membrane; microtubule; microtubule cytoskeleton; postsynaptic density

Molecular Funct
ion: actin binding; ATPase activity; microtubule binding; protein binding

Biological Process: cell motility; establishment and/or maintenance of cell polarity; mesoderm formation; positive regulation of Wnt receptor signaling pathway; posttranslational protein targeting to membrane; protein localization; regulation of focal adhesion formation; regulation of microtubule-based process; Wnt receptor signaling pathway; wound healing
 Macf1 ELISA Kit
 Macf1 Recombinant
 Macf1 Antibody
 Acf7 ELISA Kit
 Acf7 Recombinant
 Acf7 Antibody
 Aclp7 ELISA Kit
 Aclp7 Recombinant
 Aclp7 Antibody
 Macf ELISA Kit
 Macf Recombinant
 Macf Antibody
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Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 ELISA Kit
 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 Recombinant
 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 Antibody
Also known as Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha).
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript vari
ants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
 MACF1 Recombinant
 MACF1 Antibody
 ABP620 Recombinant
 ABP620 Antibody
 ACF7 Recombinant
 ACF7 Antibody
 KIAA0465 Recombinant
 KIAA0465 Antibody
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