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Minor histocompatibility antigen

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Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides .

Below are the list of possible Minor histocompatibility antigen products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Minor histocompatibility antigen H13

 Minor histocompatibility antigen H13 ELISA Kit
 Minor histocompatibility antigen H13 Recombinant
 Minor histocompatibility antigen H13 Antibody
Also known as Minor histocompatibility antigen H13 (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase).
HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus
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core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.23.-; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Protease

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; lysosomal membrane; membrane; rough endoplasmic reticulum

Molecular Function: aspartic endopeptidase activity, intramembrane cleaving; peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase binding

Biological Process: membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; membrane protein proteolysis; protein homotetramerization; signal peptide processing
 HM13 ELISA Kit
 HM13 Recombinant
 HM13 Antibody
 H13 ELISA Kit
 H13 Recombinant
 H13 Antibody
 IMP1 ELISA Kit
 IMP1 Recombinant
 IMP1 Antibody
 PSL3 ELISA Kit
 PSL3 Recombinant
 PSL3 Antibody
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