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Misshapen-like kinase

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Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.

Below are the list of possible Misshapen-like kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Misshapen-like kinase 1

 Misshapen-like kinase 1 ELISA Kit
 Misshapen-like kinase 1 Recombinant
 Misshapen-like kinase 1 Antibody
Also known as Misshapen-like kinase 1 (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6).
MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described.

Protein type: EC 2.7.11.1; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 fam
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Cellular Component: cytoplasm; Golgi apparatus

Molecular Function: ATP binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: actin cytoskeleton reorganization; dendrite morphogenesis; microvillus biogenesis; multicellular organismal development; negative thymic T cell selection; positive regulation of JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell migration; regulation of cell-cell adhesion; regulation of cell-matrix adhesion; synaptic transmission
 Mink1 ELISA Kit
 Mink1 Recombinant
 Mink1 Antibody
 Map4k6 ELISA Kit
 Map4k6 Recombinant
 Map4k6 Antibody
 Mink ELISA Kit
 Mink Recombinant
 Mink Antibody
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