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Mitochondrial ubiquitin ligase activator

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Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Below are the list of possible Mitochondrial ubiquitin ligase activator products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mitochondrial ubiquitin ligase activator of NFKB 1

 Mitochondrial ubiquitin ligase activator of NFKB 1 ELISA Kit
 Mitochondrial ubiquitin ligase activator of NFKB 1 Recombinant
 Mitochondrial ubiquitin ligase activator of NFKB 1 Antibody
Also known as Mitochondrial ubiquitin ligase activator of NFKB 1 (E3 SUMO-protein ligase MUL1) (E3 ubiquitin-protein ligase MUL1) (Growth inhibition and death E3 ligase) (Mitochondrial-anchored protein ligase) (MAPL) (Putative NF-kappa-B-activating protein.
MULAN: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MA
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P3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein type: Apoptosis; EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: axon; cell soma; cytoplasm; integral to mitochondrial outer membrane; membrane; mitochondrion; nucleoplasm; peroxisome

Molecular Function: identical protein binding; protein binding; signal transducer activity; SUMO ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity

Biological Process: activation of JNK activity; caspase activation; mitochondrial fission; mitochondrion localization; negative regulation of cell growth; negative regulation of defense response to virus by host; negative regulation of innate immune response; negative regulation of protein kinase B signaling cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein sumoylation; protein destabilization; protein stabilization; protein ubiquitination
 MUL1 ELISA Kit
 MUL1 Recombinant
 MUL1 Antibody
 C1orf166 ELISA Kit
 C1orf166 Recombinant
 C1orf166 Antibody
 GIDE ELISA Kit
 GIDE Recombinant
 GIDE Antibody
 MAPL ELISA Kit
 MAPL Recombinant
 MAPL Antibody
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Mitochondrial ubiquitin ligase activator of nfkb 1-A

 Mitochondrial ubiquitin ligase activator of nfkb 1-A ELISA Kit
 Mitochondrial ubiquitin ligase activator of nfkb 1-A Recombinant
 Mitochondrial ubiquitin ligase activator of nfkb 1-A Antibody
Also known as Mitochondrial ubiquitin ligase activator of nfkb 1-A (E3 ubiquitin-protein ligase mul1-A).
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates ().
 mul1a ELISA Kit
 mul1a Recombinant
 mul1a Antibody
 mul1 ELISA Kit
 mul1 Recombinant
 mul1 Antibody
 zgc:92166 ELISA Kit
 zgc:92166 Recombinant
 zgc:92166 Antibody
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