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Mitogen-activated protein kinase kinase kinase

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Activates the JUN N-terminal pathway during dorsal closure.

Below are the list of possible Mitogen-activated protein kinase kinase kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mitogen-activated protein kinase kinase kinase

 Mitogen-activated protein kinase kinase kinase ELISA Kit
 Mitogen-activated protein kinase kinase kinase Recombinant
 Mitogen-activated protein kinase kinase kinase Antibody
Also known as Mitogen-activated protein kinase kinase kinase (Mixed lineage kinase) (Protein slipper) (dMLK).
Activates the JUN N-terminal pathway during dorsal closure.
 slpr ELISA Kit
 slpr Recombinant
 slpr Antibody
 Mlk2 ELISA Kit
 Mlk2 Recombinant
 Mlk2 Antibody
 CG2272 ELISA Kit
 CG2272 Recombinant
 CG2272 Antibody
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Mitogen-activated protein kinase kinase kinase 1

 Mitogen-activated protein kinase kinase kinase 1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 1 Recombinant
 Mitogen-activated protein kinase kinase kinase 1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 1 (ARAKIN) (AtMEKK1) (MAP kinase kinase kinase 1).
Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are
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described in Trends in Plant Science 2002, 7(7):301. Mediates cold, salt, cadmium and wounding stress signalling. Phosphorylates MEK1.
 MEKK1 ELISA Kit
 MEKK1 Recombinant
 MEKK1 Antibody
 At4g08500 ELISA Kit
 At4g08500 Recombinant
 At4g08500 Antibody
 T15F16.5 ELISA Kit
 T15F16.5 Recombinant
 T15F16.5 Antibody
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Mitogen-activated protein kinase kinase kinase 10

 Mitogen-activated protein kinase kinase kinase 10 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 10 Recombinant
 Mitogen-activated protein kinase kinase kinase 10 Antibody
MLK2: a TKL kinase of the MLK family. A dual leucine zipper kinase. Phosphorylates and activates JNK and SEK1. Interacts with PAK and NCK. May be involved in nerve growth factor-induced neuronal apoptosis.

Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Cellular Component: cytoplasm

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Molecular Function: bHLH transcription factor binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity

Biological Process: cell death; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; protein amino acid phosphorylation; smoothened signaling pathway
 Map3k10 ELISA Kit
 Map3k10 Recombinant
 Map3k10 Antibody
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Mitogen-activated protein kinase kinase kinase 11

 Mitogen-activated protein kinase kinase kinase 11 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 11 Recombinant
 Mitogen-activated protein kinase kinase kinase 11 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 11 (Mixed lineage kinase 3).
MLK3: a TKL kinase of the MLK family. Has an amino-terminal SH3 domain followed by the kinase domain, two leucine zipper domains, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. Phosphorylates IkappaB and activates SEK1 and MKK7.

Protein type: EC 2
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.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Cellular Component: centrosome; membrane; microtubule

Molecular Function: ATP binding; identical protein binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Rac GTPase binding

Biological Process: activation of JNK activity; activation of JNKK activity; activation of MAPK activity; cell death; cell proliferation; JNK cascade; microtubule-based process; positive regulation of apoptosis; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation
 Map3k11 ELISA Kit
 Map3k11 Recombinant
 Map3k11 Antibody
 Mlk3 ELISA Kit
 Mlk3 Recombinant
 Mlk3 Antibody
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Mitogen-activated protein kinase kinase kinase 12

 Mitogen-activated protein kinase kinase kinase 12 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 12 Recombinant
 Mitogen-activated protein kinase kinase kinase 12 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 12 (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase).
DLK: May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family
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. MAP kinase kinase kinase subfamily.

Protein type: EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: cytoplasm; cytosol; membrane; plasma membrane

Molecular Function: protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; signal transducer activity

Biological Process: histone phosphorylation; JNK cascade; MAPKKK cascade; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation
 MAP3K12 ELISA Kit
 MAP3K12 Recombinant
 MAP3K12 Antibody
 ZPK ELISA Kit
 ZPK Recombinant
 ZPK Antibody
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Mitogen-activated protein kinase kinase kinase 13

 Mitogen-activated protein kinase kinase kinase 13 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 13 Recombinant
 Mitogen-activated protein kinase kinase kinase 13 Antibody
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B ().
 MAP3K13 ELISA Kit
 MAP3K13 Recombinant
 MAP3K13 Antibody
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Mitogen-activated protein kinase kinase kinase 13-A

 Mitogen-activated protein kinase kinase kinase 13-A ELISA Kit
 Mitogen-activated protein kinase kinase kinase 13-A Recombinant
 Mitogen-activated protein kinase kinase kinase 13-A Antibody
May have a role in the JNK signaling pathway.
 map3k13-a ELISA Kit
 map3k13-a Recombinant
 map3k13-a Antibody
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Mitogen-activated protein kinase kinase kinase 13-B

 Mitogen-activated protein kinase kinase kinase 13-B ELISA Kit
 Mitogen-activated protein kinase kinase kinase 13-B Recombinant
 Mitogen-activated protein kinase kinase kinase 13-B Antibody
May have a role in the JNK signaling pathway.
 map3k13-b ELISA Kit
 map3k13-b Recombinant
 map3k13-b Antibody
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Mitogen-activated protein kinase kinase kinase 14

 Mitogen-activated protein kinase kinase kinase 14 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 14 Recombinant
 Mitogen-activated protein kinase kinase kinase 14 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 14 (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK).
Nik: a protein kinase of the STE group of kinases. Binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tu
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mour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; cytosol

Molecular Function: kinase activity; NF-kappaB-inducing kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; T cell costimulation; tumor necrosis factor-mediated signaling pathway
 MAP3K14 ELISA Kit
 MAP3K14 Recombinant
 MAP3K14 Antibody
 NIK ELISA Kit
 NIK Recombinant
 NIK Antibody
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Mitogen-activated protein kinase kinase kinase 15

 Mitogen-activated protein kinase kinase kinase 15 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 15 Recombinant
 Mitogen-activated protein kinase kinase kinase 15 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 15 (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15).
MAP3K15: May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 3 i
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soforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Chromosomal Location of Human Ortholog: Xp22.12

Molecular Function: MAP kinase kinase kinase activity

Biological Process: activation of MAPKK activity
 MAP3K15 ELISA Kit
 MAP3K15 Recombinant
 MAP3K15 Antibody
 ASK3 ELISA Kit
 ASK3 Recombinant
 ASK3 Antibody
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Mitogen-activated protein kinase kinase kinase 19

 Mitogen-activated protein kinase kinase kinase 19 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 19 Recombinant
 Mitogen-activated protein kinase kinase kinase 19 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 19 (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4).
YSK4: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Chromosomal Location of Human Ortholog: 2q21.3

Cellular Component: cytoplasm

Molecular Function: receptor signaling protein ser
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ine/threonine kinase activity

Biological Process: actin cytoskeleton organization and biogenesis
 MAP3K19 ELISA Kit
 MAP3K19 Recombinant
 MAP3K19 Antibody
 RCK ELISA Kit
 RCK Recombinant
 RCK Antibody
 YSK4 ELISA Kit
 YSK4 Recombinant
 YSK4 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase 2

 Mitogen-activated protein kinase kinase kinase 2 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 2 Recombinant
 Mitogen-activated protein kinase kinase kinase 2 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 2 (Arabidopsis NPK1-related protein kinase 2).
Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1.
 ANP2 ELISA Kit
 ANP2 Recombinant
 ANP2 Antibody
 At1g54960 ELISA Kit
 At1g54960 Recombinant
 At1g54960 Antibody
 F14C21.49 ELISA Kit
 F14C21.49 Recombinant
 F14C21.49 Antibody
 T24C10.7 ELISA Kit
 T24C10.7 Recombinant
 T24C10.7 Antibody
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Mitogen-activated protein kinase kinase kinase 3

 Mitogen-activated protein kinase kinase kinase 3 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 3 Recombinant
 Mitogen-activated protein kinase kinase kinase 3 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 3 (Arabidopsis NPK1-related protein kinase 3).
Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1.
 ANP3 ELISA Kit
 ANP3 Recombinant
 ANP3 Antibody
 At3g06030 ELISA Kit
 At3g06030 Recombinant
 At3g06030 Antibody
 F24F17.1 ELISA Kit
 F24F17.1 Recombinant
 F24F17.1 Antibody
 F2O10.1 ELISA Kit
 F2O10.1 Recombinant
 F2O10.1 Antibody
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Mitogen-activated protein kinase kinase kinase 4

 Mitogen-activated protein kinase kinase kinase 4 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 4 Recombinant
 Mitogen-activated protein kinase kinase kinase 4 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 4 (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4).
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors.
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This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, May 2014]
 MAP3K4 ELISA Kit
 MAP3K4 Recombinant
 MAP3K4 Antibody
 KIAA0213 ELISA Kit
 KIAA0213 Recombinant
 KIAA0213 Antibody
 MAPKKK4 ELISA Kit
 MAPKKK4 Recombinant
 MAPKKK4 Antibody
 MEKK4 ELISA Kit
 MEKK4 Recombinant
 MEKK4 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase 5

 Mitogen-activated protein kinase kinase kinase 5 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 5 Recombinant
 Mitogen-activated protein kinase kinase kinase 5 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 5 (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5).
ASK1: a MAP kinase kinase kinase of the STE11 family, apoptosis signal-regulating kinase 1 (ASK1) plays essential roles in stress-induced apoptosis. Activated by various stressors, including oxidative stress, endoplasmic reticulum stress, and calcium overload, as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) and lipopolysaccharide (LPS). In turn, ASK1 phosphorylates and activates two dif
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ferent subgroups of MAP kinase kinases, MKK4/SEK1 and MKK3/MKK6, which in turn activate stress-activated protein kinases (JNKs) and p38 subgroups of MAP kinases, respectively. Overexpression activates JNK and p38 and induces apoptosis in several cell types through signals involving the mitochondrial cell death pathway. Embryonic fibroblasts or primary neurons derived from ASK1-/- mice are resistant to stress-induced JNK and p38 activation as well as cell death. Oxidative stress induces the activation of ASK1, which correlate with ASK1 activity and ASK1-dependent apoptosis. Required for the innate immune response, which is essential for host defense against a wide range of pathogens.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Cellular Component: cytoplasm; cytosol; external side of plasma membrane

Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activity; protein binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein phosphatase binding

Biological Process: activation of MAPK activity; activation of MAPKK activity; induction of apoptosis by oxidative stress; JNK cascade; MAPKKK cascade; positive regulation of apoptosis; positive regulation of caspase activity; positive regulation of JNK activity; positive regulation of JNK cascade; positive regulation of myoblast differentiation; positive regulation of protein amino acid phosphorylation; protein amino acid phosphorylation
 Map3k5 ELISA Kit
 Map3k5 Recombinant
 Map3k5 Antibody
 Ask1 ELISA Kit
 Ask1 Recombinant
 Ask1 Antibody
 Mekk5 ELISA Kit
 Mekk5 Recombinant
 Mekk5 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase 6

 Mitogen-activated protein kinase kinase kinase 6 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 6 Recombinant
 Mitogen-activated protein kinase kinase kinase 6 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 6 (Apoptosis signal-regulating kinase 2).
MEKK6: a member of the STE11 protein kinase family. Activates JNK, but not ERK or p38. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family

Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activity

Biological Process: activation of MAPKK activity; protein a
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mino acid phosphorylation
 Map3k6 ELISA Kit
 Map3k6 Recombinant
 Map3k6 Antibody
 Ask2 ELISA Kit
 Ask2 Recombinant
 Ask2 Antibody
 Mapkkk6 ELISA Kit
 Mapkkk6 Recombinant
 Mapkkk6 Antibody
 Mekk6 ELISA Kit
 Mekk6 Recombinant
 Mekk6 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase 7

 Mitogen-activated protein kinase kinase kinase 7 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 7 Recombinant
 Mitogen-activated protein kinase kinase kinase 7 Antibody
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (T
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LR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B (). Promotes TRIM5 capsid-specific restriction activity ().
 MAP3K7 ELISA Kit
 MAP3K7 Recombinant
 MAP3K7 Antibody
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Mitogen-activated protein kinase kinase kinase 8

 Mitogen-activated protein kinase kinase kinase 8 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 8 Recombinant
 Mitogen-activated protein kinase kinase kinase 8 Antibody
Also known as Mitogen-activated protein kinase kinase kinase 8 (Cancer Osaka thyroid oncogene) (Proto-oncogene c-Cot) (Serine/threonine-protein kinase cot) (Tumor progression locus 2) (TPL-2).
Cot: an oncogenic Ser/Thr kinase of the STE group. Activates IkappaB kinases, thus inducing the nuclear translocation of NF-kappaB. Promotes the production of TNF-alpha and IL-2 during T lymphocyte activation. Interacts with NFkB-p105. Overexpressed and amplified in breast tumors. Viral insertions induce rat lymphomas and mouse mammary carcinomas. Isolated as a transforming factor in two cell lines.
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Mediates LPS activation of macrophages. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: EC 2.7.11.25; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE-Unique family

Cellular Component: cytoplasm

Molecular Function: MAP kinase kinase kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: apoptosis
 Map3k8 ELISA Kit
 Map3k8 Recombinant
 Map3k8 Antibody
 Cot ELISA Kit
 Cot Recombinant
 Cot Antibody
 Tpl2 ELISA Kit
 Tpl2 Recombinant
 Tpl2 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase 9

 Mitogen-activated protein kinase kinase kinase 9 ELISA Kit
 Mitogen-activated protein kinase kinase kinase 9 Recombinant
 Mitogen-activated protein kinase kinase kinase 9 Antibody
MLK1: a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling.

Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Molecular Function: protein serine/threonine kinase activity

Biological
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Process: cell death; positive regulation of apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation
 Map3k9 ELISA Kit
 Map3k9 Recombinant
 Map3k9 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase A

 Mitogen-activated protein kinase kinase kinase A ELISA Kit
 Mitogen-activated protein kinase kinase kinase A Recombinant
 Mitogen-activated protein kinase kinase kinase A Antibody
Also known as Mitogen-activated protein kinase kinase kinase A (MAPK/ERK kinase 1) (MEK kinase 1) (MEKK 1) (MAPK/ERK kinase A) (MEK kinase A) (MEKK A) (MEKKalpha).
Regulates cell-type differentiation and spatial patterning, required for the proper induction and maintenance of prespore cell differentiation.
 mkkA ELISA Kit
 mkkA Recombinant
 mkkA Antibody
 DDB_G0283265 ELISA Kit
 DDB_G0283265 Recombinant
 DDB_G0283265 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase ANP1

 Mitogen-activated protein kinase kinase kinase ANP1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase ANP1 Recombinant
 Mitogen-activated protein kinase kinase kinase ANP1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase ANP1 (Arabidopsis NPK1-related kinase 1).
May be involved in an oxidative stress-mediated signaling cascade that phosphorylates downstream MAP kinases MPK3 and MPK6. May suppress auxin signaling that promotes cell cycle. Functionally redundant to ANP2 and ANP3 in the positive regulation of cytokinesis.
 ANP1 ELISA Kit
 ANP1 Recombinant
 ANP1 Antibody
 At1g09000 ELISA Kit
 At1g09000 Recombinant
 At1g09000 Antibody
 F7G19.13 ELISA Kit
 F7G19.13 Recombinant
 F7G19.13 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase dlk-1

 Mitogen-activated protein kinase kinase kinase dlk-1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase dlk-1 Recombinant
 Mitogen-activated protein kinase kinase kinase dlk-1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase dlk-1 (DAP kinase-like kinase) (Death-associated protein kinase-like kinase).
Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4 ().
 dlk-1 ELISA Kit
 dlk-1 Recombinant
 dlk-1 Antibody
 CBG08707 ELISA Kit
 CBG08707 Recombinant
 CBG08707 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase mlk-1

 Mitogen-activated protein kinase kinase kinase mlk-1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase mlk-1 Recombinant
 Mitogen-activated protein kinase kinase kinase mlk-1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase mlk-1 (Mixed lineage kinase homolog 1).
Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:20008556). Involved in the response to environmental stress such as heavy metals (PubMed:151160
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70, PubMed:18809575). By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury (PubMed:21670305, PubMed:23072806, PubMed:22388962).
 mlk-1 ELISA Kit
 mlk-1 Recombinant
 mlk-1 Antibody
 K11D12.10 ELISA Kit
 K11D12.10 Recombinant
 K11D12.10 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase MLK4

 Mitogen-activated protein kinase kinase kinase MLK4 ELISA Kit
 Mitogen-activated protein kinase kinase kinase MLK4 Recombinant
 Mitogen-activated protein kinase kinase kinase MLK4 Antibody
Also known as Mitogen-activated protein kinase kinase kinase MLK4 (Mixed lineage kinase 4).
MLK4: Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily
>>>
; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group
 Mlk4 ELISA Kit
 Mlk4 Recombinant
 Mlk4 Antibody
 Kiaa1804 ELISA Kit
 Kiaa1804 Recombinant
 Kiaa1804 Antibody
Table BarTOPTable Bar
 

Mitogen-activated protein kinase kinase kinase MLT

 Mitogen-activated protein kinase kinase kinase MLT ELISA Kit
 Mitogen-activated protein kinase kinase kinase MLT Recombinant
 Mitogen-activated protein kinase kinase kinase MLT Antibody
Also known as Mitogen-activated protein kinase kinase kinase MLT (Human cervical cancer suppressor gene 4 protein) (HCCS-4) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mixed lineage kina.
ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.

Protein type: EC 2.7.11.25; Kinase, protein; MLK family; MLK subfamily; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group

Chromosomal Location of Hu
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man Ortholog: 2q24.2

Cellular Component: cytoplasm

Molecular Function: ATP binding; magnesium ion binding; MAP kinase kinase kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: activation of JNK activity; activation of MAPKK activity; cell cycle arrest; cell cycle checkpoint; DNA damage checkpoint; embryonic digit morphogenesis; limb development; positive regulation of apoptosis; protein amino acid phosphorylation; response to radiation

Disease: Split-foot Malformation With Mesoaxial Polydactyly
 ZAK ELISA Kit
 ZAK Recombinant
 ZAK Antibody
 MLTK ELISA Kit
 MLTK Recombinant
 MLTK Antibody
 HCCS4 ELISA Kit
 HCCS4 Recombinant
 HCCS4 Antibody
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Mitogen-activated protein kinase kinase kinase mom-4

 Mitogen-activated protein kinase kinase kinase mom-4 ELISA Kit
 Mitogen-activated protein kinase kinase kinase mom-4 Recombinant
 Mitogen-activated protein kinase kinase kinase mom-4 Antibody
Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1 ().
 mom-4 ELISA Kit
 mom-4 Recombinant
 mom-4 Antibody
 CBG03852 ELISA Kit
 CBG03852 Recombinant
 CBG03852 Antibody
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Mitogen-activated protein kinase kinase kinase NPK1

 Mitogen-activated protein kinase kinase kinase NPK1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase NPK1 Recombinant
 Mitogen-activated protein kinase kinase kinase NPK1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase NPK1 (Nicotiana protein kinase 1).
Functions in the NACK-PQR (NPK1-NQK1/MEK1-NRK1) MAP kinase signaling pathway, which is essential for somatic cell cytokinesis, especially for the cell-plate formation and its expansion, and depends on NACK1 and NACK2 kinesin-related proteins. Functions in the regulation of resistance gene-mediated re
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sistance responses such as the N-mediated resistance to tobamovirus (TMV) and the Rx-mediated hypersensitive response (HR) to potato virus X (PVX).
 NPK1 ELISA Kit
 NPK1 Recombinant
 NPK1 Antibody
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Mitogen-activated protein kinase kinase kinase nsy-1

 Mitogen-activated protein kinase kinase kinase nsy-1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase nsy-1 Recombinant
 Mitogen-activated protein kinase kinase kinase nsy-1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase nsy-1 (Apoptosis signal-regulating kinase 1) (ASK-1) (Neuronal symmetry kinase 1).
Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1 (PubMed:11751572, PubMed:12142542, PubMed:21212236, Pu
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bMed:24448648). Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons (PubMed:11336672, PubMed:11751572, PubMed:15625192). Involved in resistance to pathogenic Gram-positive and Gram-negative bacterial and fungal infection (PubMed:12142542, PubMed:18394898, PubMed:24448648). Involved in resistance to the nematotoxic C.cinerea galectin Cgl2 (PubMed:20062796). Probably by activating the sek1/pmk-1/skn-1 pathway, involved in the up-regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacterial infection (PubMed:22216003). Probably downstream of tir-1 and nipi-3, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury (PubMed:18394898). Plays a role in resistance to several environmental stresses including oxidative, protein misfolding (ER) and osmotic stresses, and DNA-damaging reagents (PubMed:21212236, PubMed:15888317). Plays a role in the stabilization of transcription factor rnt-1 in the intestine during oxidative stress (PubMed:22308034). Involved in germline apoptosis induced by heavy metals, such as Cu2+ (PubMed:19497412). Plays a role downstream of tir-1 in regulating susceptibility to anoxia (PubMed:21212236). Involved in egg laying (PubMed:12142542).
 nsy-1 ELISA Kit
 nsy-1 Recombinant
 nsy-1 Antibody
 F59A6.1 ELISA Kit
 F59A6.1 Recombinant
 F59A6.1 Antibody
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Mitogen-activated protein kinase kinase kinase YODA

 Mitogen-activated protein kinase kinase kinase YODA ELISA Kit
 Mitogen-activated protein kinase kinase kinase YODA Recombinant
 Mitogen-activated protein kinase kinase kinase YODA Antibody
Also known as Mitogen-activated protein kinase kinase kinase YODA (YODA MAPKK kinase).
Member of MEKK subfamily, a component of the stomatal development regulatory pathway. Mutations in this locus result in embryo lethality.
 YDA ELISA Kit
 YDA Recombinant
 YDA Antibody
 At1g63700 ELISA Kit
 At1g63700 Recombinant
 At1g63700 Antibody
 F24D7.11 ELISA Kit
 F24D7.11 Recombinant
 F24D7.11 Antibody
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Proteins Root Name Listing
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