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Mitogen-activated protein kinase kinase kinase kinase

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Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.

Below are the list of possible Mitogen-activated protein kinase kinase kinase kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mitogen-activated protein kinase kinase kinase kinase 1

 Mitogen-activated protein kinase kinase kinase kinase 1 ELISA Kit
 Mitogen-activated protein kinase kinase kinase kinase 1 Recombinant
 Mitogen-activated protein kinase kinase kinase kinase 1 Antibody
Also known as Mitogen-activated protein kinase kinase kinase kinase 1 (Hematopoietic progenitor kinase) (HPK) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1).
HPK1: a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. Ma
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y play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription.

Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Cellular Component: cytoplasm; membrane

Molecular Function: ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: cell proliferation; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to stress
 Map4k1 ELISA Kit
 Map4k1 Recombinant
 Map4k1 Antibody
 Hpk1 ELISA Kit
 Hpk1 Recombinant
 Hpk1 Antibody
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Mitogen-activated protein kinase kinase kinase kinase 2

 Mitogen-activated protein kinase kinase kinase kinase 2 ELISA Kit
 Mitogen-activated protein kinase kinase kinase kinase 2 Recombinant
 Mitogen-activated protein kinase kinase kinase kinase 2 Antibody
Also known as Mitogen-activated protein kinase kinase kinase kinase 2 (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein).
GCK: Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extend of the p38 MAPKs signaling pathway. Requi
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red for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also the SAP/JNK signaling pathway and the p38 MAPKs signaling pathway through activation of the MAP3Ks MAP3K10/MLK2 and MAP3K11/MLK3. May play a role in the regulation of vesicle targeting or fusion. regulation of vesicle targeting or fusion. Interacts with TRAF2, TRAF6, MAP3K1/MEKK1 and MAP3K11/MLK3. Interacts with RAB8A. Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined. The tumor necrosis factor (TNF), as well as endotoxins and proinflammatory stimuli such as polyinosine- polycytidine (poly(IC)), lipopolysaccharides (LPS), peptidoglycan (PGN), flagellin, or lipid A activate MAP4K2 by promoting its autophosphorylation. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Protein type: EC 2.7.11.1; KHS subfamily; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 11q13

Molecular Function: ATP binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of JNK activity; immune response; JNK cascade; positive regulation of JNK cascade; protein amino acid phosphorylation
 MAP4K2 ELISA Kit
 MAP4K2 Recombinant
 MAP4K2 Antibody
 GCK ELISA Kit
 GCK Recombinant
 GCK Antibody
 RAB8IP ELISA Kit
 RAB8IP Recombinant
 RAB8IP Antibody
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Mitogen-activated protein kinase kinase kinase kinase 3

 Mitogen-activated protein kinase kinase kinase kinase 3 ELISA Kit
 Mitogen-activated protein kinase kinase kinase kinase 3 Recombinant
 Mitogen-activated protein kinase kinase kinase kinase 3 Antibody
Also known as Mitogen-activated protein kinase kinase kinase kinase 3 (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3).
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway ().
 Map4k3 ELISA Kit
 Map4k3 Recombinant
 Map4k3 Antibody
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Mitogen-activated protein kinase kinase kinase kinase 4

 Mitogen-activated protein kinase kinase kinase kinase 4 ELISA Kit
 Mitogen-activated protein kinase kinase kinase kinase 4 Recombinant
 Mitogen-activated protein kinase kinase kinase kinase 4 Antibody
Also known as Mitogen-activated protein kinase kinase kinase kinase 4 (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase).
HGK: a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via i
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ts CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Cellular Component: cytoplasm

Molecular Function: ATP binding; creatine kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: negative regulation of apoptosis; protein amino acid phosphorylation; regulation of JNK cascade; response to stress
 Map4k4 ELISA Kit
 Map4k4 Recombinant
 Map4k4 Antibody
 Nik ELISA Kit
 Nik Recombinant
 Nik Antibody
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Mitogen-activated protein kinase kinase kinase kinase 5

 Mitogen-activated protein kinase kinase kinase kinase 5 ELISA Kit
 Mitogen-activated protein kinase kinase kinase kinase 5 Recombinant
 Mitogen-activated protein kinase kinase kinase kinase 5 Antibody
Also known as Mitogen-activated protein kinase kinase kinase kinase 5 (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5).
KHS1: a serine/threonine protein kinase of the STE20 family. Highly similar to yeast SPS1/STE20 kinase. Activates Jun kinase in mammalian cells, which suggested a role in stress response.

Protein type: EC 2.7.11.1
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; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 14q11.2-q21

Cellular Component: cytoplasm

Molecular Function: ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: activation of JNK activity; protein amino acid phosphorylation
 MAP4K5 ELISA Kit
 MAP4K5 Recombinant
 MAP4K5 Antibody
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