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Mitotic checkpoint serine/threonine-protein kinase

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Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C). Necessary for ensuring proper chromosome segregation. Can regulate chromosome segregation in a kinetochore-independent manner. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity (By similarity).

Below are the list of possible Mitotic checkpoint serine/threonine-protein kinase products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mitotic checkpoint serine/threonine-protein kinase BUB1

 Mitotic checkpoint serine/threonine-protein kinase BUB1 ELISA Kit
 Mitotic checkpoint serine/threonine-protein kinase BUB1 Recombinant
 Mitotic checkpoint serine/threonine-protein kinase BUB1 Antibody
Also known as Mitotic checkpoint serine/threonine-protein kinase BUB1 (AtBUB1) (Protein BUDDING UNINHIBITED BY BENZYMIDAZOL 1).
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C). Necessary for ensuring proper chromosome segregation. Can regulate chromosome segregation in a kinetochore-independent manner. The BUB1-BUB3 com
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plex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity ().
 BUB1 ELISA Kit
 BUB1 Recombinant
 BUB1 Antibody
 At2g20635 ELISA Kit
 At2g20635 Recombinant
 At2g20635 Antibody
 F23N11.4 ELISA Kit
 F23N11.4 Recombinant
 F23N11.4 Antibody
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Mitotic checkpoint serine/threonine-protein kinase bub-1

 Mitotic checkpoint serine/threonine-protein kinase bub-1 ELISA Kit
 Mitotic checkpoint serine/threonine-protein kinase bub-1 Recombinant
 Mitotic checkpoint serine/threonine-protein kinase bub-1 Antibody
Also known as Mitotic checkpoint serine/threonine-protein kinase bub-1 (Budding uninhibited by benzimidazole 1).
Serine/threonine-protein kinase essential for spindle-assembly checkpoint signaling. Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores (PubMed:19109417, PubMed:24567362). mdf-1 recruitment is independent of bub-1 kinase a
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ctivity (PubMed:24567362). In addition, during meiotic anaphase I, controls the recruitment of hcp-1/2 and klp-19 to the ring-shaped domain formed between chromosomes (PubMed:20729837). Involved in chromosome alignment, chromosome homolog segregation and spindle assembly (PubMed:20729837, PubMed:25987605). Necessary for kinetochore localization of bub-3 (PubMed:25987605). In association with bub-3 at the kinetochore region of chromosomes, promotes the onset on anaphase independently from spindle checkpoint signaling and promotes the formation of stable end-on bipolar attachments of chromosomes (PubMed:25987605). Required maternally during embryogenesis and in the zygote for the postembryonic development of several tissues including ventral cord neurons, gonad, intestine and seam cells (PubMed:19526056).
 bub-1 ELISA Kit
 bub-1 Recombinant
 bub-1 Antibody
 R06C7.8 ELISA Kit
 R06C7.8 Recombinant
 R06C7.8 Antibody
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Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta ELISA Kit
 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Recombinant
 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Antibody
Also known as Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (MAD3/BUB1-related protein kinase) (BubR1) (Mitotic checkpoint kinase MAD3L).
BUB1B: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhi
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bit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. Interacts with CENPE, CENPF, mitosin, PLK1 and BUB3. Part of a complex containing BUB3, CDC20 and BUB1B. Interacts with anaphase-promoting complex/cyclosome (APC/C). Interacts with CASC5. Induced during mitosis. Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index. Kinase activity stimulated by CENPE. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: BUB family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor

Cellular Component: cytoplasm; kinetochore; outer kinetochore of condensed chromosome; perinuclear region of cytoplasm

Molecular Function: protein binding

Biological Process: mitotic metaphase/anaphase transition
 Bub1b ELISA Kit
 Bub1b Recombinant
 Bub1b Antibody
 Mad3l ELISA Kit
 Mad3l Recombinant
 Mad3l Antibody
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