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Mitotic spindle assembly checkpoint protein

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Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (By similarity).

Below are the list of possible Mitotic spindle assembly checkpoint protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mitotic spindle assembly checkpoint protein MAD1

 Mitotic spindle assembly checkpoint protein MAD1 ELISA Kit
 Mitotic spindle assembly checkpoint protein MAD1 Recombinant
 Mitotic spindle assembly checkpoint protein MAD1 Antibody
Also known as Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1).
MAD1L1: a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery.
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Expressed weakly at G0/G1 and highly at late S and G2/M phase. Induced by p53. Becomes hyperphosphorylated in late S through M phases or after mitotic spindle damage. Two alternatively spliced isoforms have been described. Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.

Protein type: Cell cycle regulation; Cytoskeletal

Cellular Component: actin cytoskeleton; cytoplasm; kinetochore; nuclear envelope; nuclear pore; nucleus; spindle pole

Biological Process: attachment of spindle microtubules to kinetochore during mitosis; mitotic cell cycle spindle assembly checkpoint; negative regulation of T cell proliferation; thymus development
 Mad1l1 ELISA Kit
 Mad1l1 Recombinant
 Mad1l1 Antibody
 Mad1 ELISA Kit
 Mad1 Recombinant
 Mad1 Antibody
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Mitotic spindle assembly checkpoint protein MAD2A

 Mitotic spindle assembly checkpoint protein MAD2A ELISA Kit
 Mitotic spindle assembly checkpoint protein MAD2A Recombinant
 Mitotic spindle assembly checkpoint protein MAD2A Antibody
Also known as Mitotic spindle assembly checkpoint protein MAD2A (HsMAD2) (Mitotic arrest deficient 2-like protein 1) (MAD2-like protein 1).
MAD2L1: required for the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. Inhibits the activity of the anaphase promoting complex by sequestering CDC20 until
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all chromosomes are aligned at the metaphase plate. Interacts with Cdc20, MAD2L1BP and with ADAM17/TACE

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: cytosol; kinetochore; nuclear pore; nucleus; perinuclear region of cytoplasm

Molecular Function: identical protein binding; protein binding; protein homodimerization activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle checkpoint; negative regulation of apoptosis; negative regulation of mitotic cell cycle; negative regulation of protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; sister chromatid cohesion
 MAD2L1 ELISA Kit
 MAD2L1 Recombinant
 MAD2L1 Antibody
 MAD2 ELISA Kit
 MAD2 Recombinant
 MAD2 Antibody
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Mitotic spindle assembly checkpoint protein MAD2B

 Mitotic spindle assembly checkpoint protein MAD2B ELISA Kit
 Mitotic spindle assembly checkpoint protein MAD2B Recombinant
 Mitotic spindle assembly checkpoint protein MAD2B Antibody
Also known as Mitotic spindle assembly checkpoint protein MAD2B (Mad2l2-A protein) (Mitotic arrest defective protein 2B) (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (xMAD2L2).
Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit rev3l and the inserter polymerase rev1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases,
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stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Through transcriptional regulation may play a role in epithelial-mesenchymal transdifferentiation.
 mad2l2 ELISA Kit
 mad2l2 Recombinant
 mad2l2 Antibody
 mad2B ELISA Kit
 mad2B Recombinant
 mad2B Antibody
 mad2l2-a ELISA Kit
 mad2l2-a Recombinant
 mad2l2-a Antibody
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