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MMS19 nucleotide excision repair protein

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Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Below are the list of possible MMS19 nucleotide excision repair protein products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

MMS19 nucleotide excision repair protein homolog

 MMS19 nucleotide excision repair protein homolog ELISA Kit
 MMS19 nucleotide excision repair protein homolog Recombinant
 MMS19 nucleotide excision repair protein homolog Antibody
Also known as MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein).
MMS19: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter be
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tween early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Belongs to the MET18/MMS19 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q24-q25

Cellular Component: cytoplasm; membrane; nucleoplasm; nucleus; spindle

Molecular Function: estrogen receptor binding; protein binding; transcription coactivator activity

Biological Process: chromosome segregation; DNA metabolic process; DNA repair; iron-sulfur cluster assembly; nucleotide-excision repair; positive regulation of transcription, DNA-dependent; response to DNA damage stimulus
 MMS19 ELISA Kit
 MMS19 Recombinant
 MMS19 Antibody
 MMS19L ELISA Kit
 MMS19L Recombinant
 MMS19L Antibody
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