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Mothers against decapentaplegic

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Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression .

Below are the list of possible Mothers against decapentaplegic products. If you cannot find the target and/or product is not available in our catalog, please click here to contact us and request the product or submit your request for custom elisa kit production, custom recombinant protein production or custom antibody production. Custom ELISA Kits, Recombinant Proteins and Antibodies can be designed, manufactured and produced according to the researcher's specifications.
 

Mothers against decapentaplegic homolog 1

 Mothers against decapentaplegic homolog 1 ELISA Kit
 Mothers against decapentaplegic homolog 1 Recombinant
 Mothers against decapentaplegic homolog 1 Antibody
Also known as Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (Dwarfin-A) (Dwf-A) (Mothers-against-DPP-related 1) (Mad-related protein 1) (mMad1) (SMAD family member 1) (SMAD 1) (Smad1).
SMAD1: transcription factor phosphorylated and activated by bone morphogenetic protein type 1 receptor kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated forms dimerize with collaborating Smad4 and are translocated into the nucleus, where the trans
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cription of target genes is stimulated.

Protein type: DNA-binding; Transcription factor

Cellular Component: cytoplasm; nuclear inner membrane; nucleus; protein complex; transcription factor complex

Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; transcription factor activity

Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cartilage development; gamete generation; hindbrain development; homeostatic process; inflammatory response; MAPKKK cascade; mesodermal cell fate commitment; midbrain development; negative regulation of cell proliferation; osteoblast fate commitment; positive regulation of cell differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of transcription from RNA polymerase II promoter; response to drug; SMAD protein complex assembly; ureteric bud development
 Smad1 ELISA Kit
 Smad1 Recombinant
 Smad1 Antibody
 Madh1 ELISA Kit
 Madh1 Recombinant
 Madh1 Antibody
 Madr1 ELISA Kit
 Madr1 Recombinant
 Madr1 Antibody
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Mothers against decapentaplegic homolog 2

 Mothers against decapentaplegic homolog 2 ELISA Kit
 Mothers against decapentaplegic homolog 2 Recombinant
 Mothers against decapentaplegic homolog 2 Antibody
Also known as Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2).
SMAD2: ubiquitously expressed transcription factor phosphorylated and activated by TGF-beta receptor-type kinases. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where the transcription of target genes is st
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imulated. Two alternatively spliced isoforms have been described.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; transcription factor complex

Molecular Function: DNA binding; double-stranded DNA binding; phosphatase binding; protein binding; SMAD binding; transcription activator binding; transcription factor activity; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin protein ligase binding

Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; cell fate commitment; common-partner SMAD protein phosphorylation; gastrulation; mesoderm formation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor beta receptor signaling pathway; palate development; paraxial mesoderm morphogenesis; positive regulation of BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; primary microRNA processing; regulation of binding; regulation of transforming growth factor beta receptor signaling pathway; SMAD protein complex assembly; somatic stem cell maintenance; transforming growth factor beta receptor signaling pathway; zygotic determination of dorsal/ventral axis
 SMAD2 ELISA Kit
 SMAD2 Recombinant
 SMAD2 Antibody
 MADH2 ELISA Kit
 MADH2 Recombinant
 MADH2 Antibody
 MADR2 ELISA Kit
 MADR2 Recombinant
 MADR2 Antibody
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Mothers against decapentaplegic homolog 3

 Mothers against decapentaplegic homolog 3 ELISA Kit
 Mothers against decapentaplegic homolog 3 Recombinant
 Mothers against decapentaplegic homolog 3 Antibody
Also known as Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3).
SMAD3: transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse requi
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red for establishemnt of the mucosal immune response and proper development of skeleton.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 15q22.33

Cellular Component: cytoplasm; cytosol; nuclear chromatin; nuclear inner membrane; nucleoplasm; nucleus; receptor complex; transcription factor complex

Molecular Function: bHLH transcription factor binding; identical protein binding; phosphatase binding; protein binding; protein homodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding; transforming growth factor beta receptor binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: activin receptor signaling pathway; caspase activation; cell cycle arrest; evasion of host defenses by virus; immune response; intercellular junction assembly and maintenance; negative regulation of cell growth; negative regulation of fat cell differentiation; negative regulation of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; primary microRNA processing; reduction of cytosolic calcium ion concentration; regulation of transcription from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; SMAD protein complex assembly; transforming growth factor beta receptor signaling pathway; transport; wound healing

Disease: Loeys-dietz Syndrome 3
 SMAD3 ELISA Kit
 SMAD3 Recombinant
 SMAD3 Antibody
 MADH3 ELISA Kit
 MADH3 Recombinant
 MADH3 Antibody
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Mothers against decapentaplegic homolog 4

 Mothers against decapentaplegic homolog 4 ELISA Kit
 Mothers against decapentaplegic homolog 4 Recombinant
 Mothers against decapentaplegic homolog 4 Antibody
Also known as Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (SMAD family member 4) (SMAD 4) (Smad4).
SMAD4: transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription.

Protein type: DNA-bindin
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g; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; nuclear chromatin; nucleus; protein complex; transcription factor complex

Molecular Function: chromatin binding; collagen binding; DNA binding; filamin binding; identical protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding; SMAD binding; transcription factor activity; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity

Biological Process: anterior/posterior pattern formation; axon guidance; BMP signaling pathway; cell proliferation; cellular iron ion homeostasis; developmental growth; embryonic digit morphogenesis; endoderm development; endothelial cell activation; female gonad development; formation of anatomical boundary; gastrulation; gastrulation with mouth forming second; in utero embryonic development; kidney development; male gonad development; mesoderm development; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of protein catabolic process; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural crest cell differentiation; neuron fate commitment; ovarian follicle development; palate development; positive regulation of BMP signaling pathway; positive regulation of follicle-stimulating hormone secretion; positive regulation of histone H3-K4 methylation; positive regulation of luteinizing hormone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of binding; regulation of cell proliferation; regulation of hair follicle development; regulation of transcription from RNA polymerase II promoter; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor-beta2 production; response to hypoxia; sebaceous gland development; single fertilization; SMAD protein complex assembly; somite rostral/caudal axis specification; spermatogenesis; tissue morphogenesis; transforming growth factor beta receptor signaling pathway; ureteric bud branching; uterus development
 Smad4 ELISA Kit
 Smad4 Recombinant
 Smad4 Antibody
 Dpc4 ELISA Kit
 Dpc4 Recombinant
 Dpc4 Antibody
 Madh4 ELISA Kit
 Madh4 Recombinant
 Madh4 Antibody
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Mothers against decapentaplegic homolog 5

 Mothers against decapentaplegic homolog 5 ELISA Kit
 Mothers against decapentaplegic homolog 5 Recombinant
 Mothers against decapentaplegic homolog 5 Antibody
Also known as Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (Dwarfin-C) (Dwf-C) (SMAD family member 5) (SMAD 5) (Smad5) (mSmad5).
SMAD5: transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis.

Protein type: DNA-b
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inding; Transcription, coactivator/corepressor

Cellular Component: cytoplasm; nucleoplasm; nucleus; protein complex

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: BMP signaling pathway; cardiac muscle contraction; cartilage development; erythrocyte differentiation; germ cell development; Mullerian duct regression; osteoblast fate commitment; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; transforming growth factor beta receptor signaling pathway; ureteric bud development
 Smad5 ELISA Kit
 Smad5 Recombinant
 Smad5 Antibody
 Madh5 ELISA Kit
 Madh5 Recombinant
 Madh5 Antibody
 Msmad5 ELISA Kit
 Msmad5 Recombinant
 Msmad5 Antibody
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Mothers against decapentaplegic homolog 6

 Mothers against decapentaplegic homolog 6 ELISA Kit
 Mothers against decapentaplegic homolog 6 Recombinant
 Mothers against decapentaplegic homolog 6 Antibody
Also known as Mothers against decapentaplegic homolog 6 (MAD homolog 6) (Mothers against DPP homolog 6) (Mad homolog 7) (SMAD family member 6) (SMAD 6) (Smad6).
SMAD6: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Interacts with NEDD4L. Interacts with WWP1. Interacts with RNF1
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11 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. Belongs to the dwarfin/SMAD family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: nucleus; protein complex

Molecular Function: chromatin binding; protein binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; ubiquitin protein ligase binding

Biological Process: BMP signaling pathway; cell-substrate adhesion; fat cell differentiation; immune response; negative regulation of apoptosis; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of ossification; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of vasodilation; positive regulation of vasoconstriction; ureteric bud development; zygotic determination of dorsal/ventral axis
 Smad6 ELISA Kit
 Smad6 Recombinant
 Smad6 Antibody
 Madh6 ELISA Kit
 Madh6 Recombinant
 Madh6 Antibody
 Madh7 ELISA Kit
 Madh7 Recombinant
 Madh7 Antibody
 Msmad6 ELISA Kit
 Msmad6 Recombinant
 Msmad6 Antibody
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Mothers against decapentaplegic homolog 7

 Mothers against decapentaplegic homolog 7 ELISA Kit
 Mothers against decapentaplegic homolog 7 Recombinant
 Mothers against decapentaplegic homolog 7 Antibody
Also known as Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7).
SMAD7: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting
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the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Genetic variations in SMAD7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. Cancers of the large intestine are the second most common form of cancer found in males and females. Symptoms include rectal bleeding, occult blood in stools, bowel obstruction and weight loss. Treatment is based largely on the extent of cancer penetration into the intestinal wall. Surgical cures are possible if the malignancy is confined to the intestine. Risk can be reduced when following a diet which is low in fat and high in fiber. Belongs to the dwarfin/SMAD family.

Protein type: DNA-binding; Transcription factor

Cellular Component: catenin complex; cell-cell adherens junction; centrosome; cytoplasm; nucleolus; nucleoplasm; nucleus; plasma membrane; protein complex

Molecular Function: activin binding; beta-catenin binding; collagen binding; protein binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; ubiquitin protein ligase binding

Biological Process: artery morphogenesis; negative regulation of BMP signaling pathway; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein ubiquitination; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of ubiquitin-protein ligase activity; positive regulation of cell-cell adhesion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; protein stabilization; regulation of activin receptor signaling pathway; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; ureteric bud development; ventricular cardiac muscle morphogenesis
 Smad7 ELISA Kit
 Smad7 Recombinant
 Smad7 Antibody
 Madh7 ELISA Kit
 Madh7 Recombinant
 Madh7 Antibody
 Madh8 ELISA Kit
 Madh8 Recombinant
 Madh8 Antibody
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Mothers against decapentaplegic homolog 9

 Mothers against decapentaplegic homolog 9 ELISA Kit
 Mothers against decapentaplegic homolog 9 Recombinant
 Mothers against decapentaplegic homolog 9 Antibody
Also known as Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9).
SMAD9: transcription factor phosphorylated and activated by bone morphogenetic protein receptor kinases. Phosphorylated Smads dimerize with collaborating Smad4 and are translocated into the nucleus, where they regulate transcription of target genes. Participates in a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation and apoptosis. Two alternatively spliced products have been de
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scribed.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 13q12-q14

Cellular Component: cytoplasm; cytosol; intracellular; nucleoplasm; nucleus

Molecular Function: protein binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity

Biological Process: BMP signaling pathway

Disease: Pulmonary Hypertension, Primary, 2
 SMAD9 ELISA Kit
 SMAD9 Recombinant
 SMAD9 Antibody
 MADH6 ELISA Kit
 MADH6 Recombinant
 MADH6 Antibody
 MADH9 ELISA Kit
 MADH9 Recombinant
 MADH9 Antibody
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